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Showing 1 to 4 of 4 for “"engineered microenvironments"”.
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MODULATING CELL DIFFERENTIATION WITH PROTEIN-ENGINEERED MICROENVIRONMENTS
… utilizes biomaterials that mimic native cellular microenvironments and provide environmental cues to induce specific cell responses, including differentiation. Biochemical and biophysical cues modulate cell behavior and direct construction of specific types of tissue. Thus, this work describes …
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Engineered microenvironments for studying liver progenitor differentiation
The bipotential differentiation of liver progenitor cells underlies liver development and bile duct formation as well as liver regeneration and disease. Both TGFβ and Notch signaling are known to play important roles in the liver progenitor specification process and subsequent tissue morphogenesis. …
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Dendritic Cell Migration and Traction Force Generation in Engineered Microenvironments
Dendritic cells (DCs) are potent initiators of the adaptive immune response. Their trafficking from sites of inflammation to lymphoid tissue is essential to their function. Exactly how dendritic cells integrate multiple chemotactic cues to organize an accurate migratory path is not fully …
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Fabrication of topographically patterned hydrogel substrates and their influence on cell morphology
… including chemistry, mechanics, and geometry. Engineered microenvironments can be used to assess a wide range of such influences on cell behavior and identify parameters for future implementation into tissue engineered scaffolds. The first goal of this work was to develop a new method for …