Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 109 for “"energy homeostasis"”.
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Developmental signaling pathways in adult energy homeostasis
… to be involved in tissue maintenance and adult energy homeostasis. Furthermore, dysfunction of these signaling pathways results in human diseases such as cancer. An in depth understanding of how developmentally important signaling pathways function in the adult will provide mechanistic insights …
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The Role of Thada in Energy Homeostasis
… strategies focused on increasing organismal energy expenditure may help fight obesity and its associated comorbidities. For this purpose, our research focused on a gene called Thada. THADA encodes a 220 kDa protein that has been recently reported in Drosophila melanogaster to uncouple the …
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The hypothalamic role of BACE1 in energy homeostasis
… leptin and insulin resistance, impaired glucose homeostasis and often inflammation and endoplasmic reticulum stress. Worryingly, obesity and T2DM are also risk factors for Alzheimer’s disease (AD).<br/>The β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is critically involved in AD …
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Molecular and cellular mechanisms of energy homeostasis in birds
… central and peripheral sites regulating energy homeostasis. Disruption of energy homeostasis can lead to diseases like anorexia and obesity in humans and reduced productivity in animals. Therefore, integrating knowledge in hypothalamic appetite regulation and adipose tissue metabolism is …
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Galanin-like peptide: a molecular link between energy homeostasis and reproduction
… does not reflect a homeostatic regulation of energy balance. I also observed that ICV GALP treatment robustly stimulates luteinizing hormone (LH) and testosterone secretion in wild-type mice. In contrast to GALP's transitory effect on body weight in wild-type mice, leptin-deficient ob/ob mice …
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Amino acid transmitters and the neural control of feeding and energy homeostasis
… is a delicate balancing act between intake and energy expenditure, and humans in modern society seem to have a keen knack for throwing the balance off-center. In the U.S. alone, more than 1/3 of adults are obese based on the body mass index scale, and $147 billion is the estimated annual medical …
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… pathways are important for maintaining metabolic homeostasis. The effects of cAMP are mediated mainly by protein kinase A (PKA) and the more recently discovered exchange protein directly activated by cAMP (Epac). Epac has two isoforms, the ubiquitously expressed Epac1 and the more tissue …
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Understanding the Molecular Basis for FGF15/19 and FGF21 Actions on Energy Homeostasis
… known to play essential roles in controlling energy balance during the fed and fasted states, respectively. Recently, additional metabolic hormones have been discovered within a subfamily of the fibroblast growth factor superfamily. The FGF15/19 subfamily is composed of atypical FGFs lacking …
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Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… pathways are important for maintaining metabolic homeostasis. The effects of cAMP are mediated mainly by protein kinase A (PKA) and the more recently discovered exchange protein directly activated by cAMP (Epac). Epac has two isoforms, the ubiquitously expressed Epac1 and the more tissue …
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Energy Homeostasis During Fasting and Fed States: Foxa2 Regulates Hepatic Amino Acid Uptake
<p>In MODY3 patients, as well in the experimental mouse model, the Tcf1 -/- mouse, there is a defect in arginine-induced insulin secretion. In this thesis, we examined the role of arginine transporters in the insulin secreting cells in arginine-induced insulin secretion. We first characterized …
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The ghrelin system links dietary lipids with the endocrine control of energy homeostasis
Ghrelin is a unique hunger-inducing stomach-borne hormone. It activates orexigenic circuits in the central nervous system (CNS) when acylated with a fatty acid residue by the Ghrelin O-acyltransferase (GOAT). Soon after the discovery of ghrelin a theoretical model emerged which suggests that the …
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Differential gestation feeding levels on sow and litter performance, nutrient digestibility and energy homeostasis
… litter performance, nutrient digestibility and energy homeostasis. In Exp. 1, a total of 160 multiparous sows were allotted to 1 of 4 dietary treatments using a randomized complete block design with BW (BW) and backfat (BF) as the blocking criteria. All sows were fed one common corn-soybean …
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The Role Of Protein Tyrosine Phosphatase 1b In The Central Regulation Of Energy Homeostasis
… phosphatase implicated in the central control of energy homeostasis via negative regulation of leptin signaling. Mice with central nervous system (CNS)-specific PTP1B deficiency demonstrate clear metabolic improvements, including decreased body weight and adiposity presumably due to enhanced …
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NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… regulators of prostate tumor cell metabolism, energy homeostasis, and survival.
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Neuropeptide FF and Neuropeptide VF and their control in the regulation of energy homeostasis and glucose metabolism
… of the regulatory mechanisms underlying energy homeostasis. This work used transgenic and knockout mouse models combined with neuronal manipulation and pathway tracing to investigate the role of the Neuropeptide FF (NPFF) and Neuropeptide VF (NPVF) in the regulation of energy balance and …
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Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
… as playing an essential role in controlling energy homeostasis. Gold-thioglucose (GTG) induces lesions in the ventromedial nucleus of the hypothalamus (VMH) resulting in hyperphagia and obesity. To identify genes involved in the hypothalamic regulation of energy homeostasis, we employed a …
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Transcriptional Regulation of Melanocortin 4 Receptor by Nescient Helix-Loop-Helix-2 and its Implications in Peripheral Energy Homeostasis
… the effects of deletion of Nhlh2 on peripheral energy expenditure, glucose homeostasis and fatty acid oxidation are reported. To investigate the transcriptional mechanisms of Mc4r and the involvement of Nhlh2, gene expression analysis, DNA-protein binding, transactivation assays, and SiRNA …
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Orexin Signaling and the Prevention of Diet-Induced Obesity
… Prolonged effects of orexin signaling upon energy homeostasis have not been fully characterized. In this study, I utilized both genetic and pharmacologic approaches to characterize metabolic effects of orexin gain of function. CAG/orexin transgenic mice confer resistance to high-fat …
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Activity Based Profiling: New Insights into Metabolic Homeostasis
… evidence that demonstrates that body weight and energy homeostasis is tightly regulated by a physiological system. This system consists of sensing and effector components that primarily reside in the central nervous system and disruption to these components can lead to obesity and metabolic …
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