Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"energetic stress"”.
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Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
… changes in actin/ cofilin dynamics under energetic stress conditions in the presence of small molecules and cofilin mimicking peptides. Our small molecule strategy uses nonhydrolyzable ATP analogues to block the formation of actin-cofilin rods in cells undergoing energetic stress. Our …
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The impact of variation in the progesterone receptor gene, life history and lifestyle on endometrial function and the menstrual cycle
… as Human Reproductive Ecology is dominated by energetic models for fecundity that disregard genetic variation as a potential cause of differences in reproduction. Further, a strong correlation between ovarian and uterine markers of fecundity is assumed, although this assumption is not supported …
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Approaches for assessing the presence and impact of thyroid hormone disrupting chemicals in Delphinid cetaceans
… which the animal utilizes during periods of energetic stress. It is important to understand how the blubber responds to factors such as ontogeny, water temperature, reproductive status, and nutritional state because blubber is also the primary bioaccumulation site for persistent organic …
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Phenotypic variation and thermoregulation of the human hand
… in living populations exposed to significant energetic stress. Upper limb segment lengths were obtained from participants (N=254; 18-59 years of age), from highland and lowland regions of the Nepalese Himalayas using established anthropometric methods, and relative hand proportions were …
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Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase β Haploinsufficient Mice
… is futile leading to a depletion of cellular energetic levels. This energetic stress is sensed by cell death machinery and as such apoptosis is invoked.</p>
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The Placental Microbiome and Preterm Birth: An Evolutionary Life History Perspective
… microbiome in responding to maternal immune stress and determining gestation length. These findings were situated in an evolutionary life history framework based on reproductive-immune trade-offs in order to develop an ultimate explanation for why natural selection has left us vulnerable to …
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Anoxia-Induced Changes in Action Potential Propagation in a Non-Myelinated Axon
Processing information in the nervous system is energetically expensive, constraining the ability of the system to survive disturbances caused by stress. While some organisms compensate for extreme changes in the abiotic features of their environment, the mechanisms underlying this are poorly …
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Targeting Glutamine Metabolism in Kidney Development and Polycystic Kidney Disease
… polarity, autophagy, mTOR signaling, and energetic stress response, all of which are dysregulated in PKD. We generated mice lacking Lkb1 in developing kidney epithelia to establish which of these processes contributed to cyst formation and progression in the absence of Lkb1. Surprisingly, …
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A matter of evolutionary life and death: an ecological model of growth and development in Homo erectus
… mortality, encephalisation, and the rate and energetic burden of growth, in order to identify the mechanism by which H. erectus adapted to a diverse range of climates and environments, and how thoroughly that adaptation was achieved. An exploration of the environmental tolerance of H erectus …
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Approaches for assessing the presence and impact of thyroid hormone disrupting chemicals in delphinid cetaceans
… which the animal utilizes during periods of energetic stress. It is important to understand how the blubber responds to factors such as ontogeny, water temperature, reproductive status, and nutritional state because blubber is also the primary bioaccumulation site for persistent organic …
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Impaired Ulk1 Ser555 Phosphorylation Promotes Amino Acid Reliance and Links Mitochondrial Inefficiency to Systemic Metabolic Inflexibility
… capacity and ability to switch between energetic substrates in response to nutrient availability—is essential for systemic energy balance and protection against metabolic disease. Loss of this adaptive capacity contributes to metabolic diseases marked by obesity, insulin resistance, and …
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Molecular ecology and fitness of striped (Stenella coeruleoalba, Meyen, 1833) and common (Delphinus delphis, Linnaeus, 1758) dolphins
… suggests that parasites may act as an energetic stress, and may reflect the non-identical pathogenesis of parasites and their ability to inflict damage through the hormone profiles. Results illustrate potentially important interactions between genetic drift and selection, and provide …
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Amylin, tissue hypoxia and metabolic dysregulation in diabetic heart and liver
… HIF2α levels being observed. Oxidative and energetic stress was also provoked. This resulted in downstream mitochondrial dysfunction and metabolic changes, including a lower Electron Transport Chain (ETC) capacity, and decreased fatty acid oxidation (FAO). In the livers of the HIP rats, the …
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Predicting Multi-trophic Consequences of an Emerging Disease
… species may prefer C. camphora fruit in times of energetic stress. The decline of P. borbonia will likely increase the consumption and dispersal of C. camphora fruits. Additional studies are required to determine if such changes could ultimately increase the distribution and abundance of this …