Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"endotypes"”.
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Genomic and metabolomic interrogation of body composition and insulin resistance endotypes
… heterogeneity into mechanistically informative endotypes, first identifying common-variant and gene-level contributors to lean-fat partitioning, nominating loci and genes plausibly contributing to healthier tissue distribution and physical resilience across ageing, and second refining …
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Endotype Discovery in Acute Respiratory Distress Syndrome
… to describe different mechanistic subtypes (endotypes) of ARDS. The endotypes described here are derived from analysis of data collected by three UK-based studies: an observational study of sepsis (GAinS), an observational study of severe influenza (MOSAIC), and a randomised controlled trial …
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Mechanisms of atopic dermatitis and allergy development in African (AmaXhosa) children between 12-36 months of age
… documented. To identify novel immunological endotypes and responsible environmental exposures in South African children with AD, we collected data on environmental exposures, lifestyle factors, and conducted clinical assessments in 217 children (Urban AD, n=56; Rural AD, n=60; Urban Healthy …
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Translating autoimmune genetic risk scores into improved prediction and classification of disease
… developing rapid autoimmunity. The suggestion of endotypes within type 1 diabetes has been proposed based on previous findings of differences in first-developing autoantibodies, age at onset and immune cell islet infiltration. In chapter 5, we evaluated this further by performing large-scale GWAS …
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Data-driven approach to identifying sub-types of adult asthma from primary care electronic health records
… with underlying physiological mechanisms (endotypes). Numerous phenotypes and endotypes of asthma have been proposed, both using hypothesis-driven and, more recently, data-driven techniques. However, inconsistencies of findings mean that scientific and clinical consensus are yet to be …
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Optimising therapeutic strategies for chronic rhinosinusitis
… in part to different disease phenotypes/endotypes, poor awareness of treatment optimization options, and trivialization of symptoms by patients and physicians. Characteristically, these factors contribute to a typical remitting and relapsing disease course. The objectives of this work are …
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Characterizing Inflammatory Mechanisms in Hidradenitis Suppurativa
… potentially introducing the concept of disease endotypes in this highly heterogeneous disease. This has direct applicability towards stratification of patients who may be better responders in the context of targeted therapy in HS.</p>