Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"endotoxemia"”.
-
Impact of endotoxemia on ovarian signaling and function
… This influx of LPS into circulation is known as endotoxemia and can arise from a myriad of physiological states, such as HS, and off-feed events, as well as obesity, diabetes, and alcoholism. Alterations to follicular growth and development incurred during endotoxemia could delay or inhibit …
-
Aquaporin-4 mediates blood brain barrier permeability during endotoxemia
… molecular weights 24 hours after induction of endotoxemia with i.p. LPS. Fluorescent microscopy using tissue sections and cleared half-brains showed that endotoxemia increased tracer penetrance into the brain parenchyma. Temporal and spatial distribution of tracers suggested that penetrance …
-
The Role of the CD14 molecule in equine endotoxemia
… diseases or other illnesses likely to result in endotoxemia; and identify relationships with clinical data. Animals - Part 1; 10 healthy horses. Part 2; 55 clinical cases and 23 healthy control horses. Procedure - Part 1; PBMCs were incubated with Escherichia coli LPS, CD14 mAb, sCD14, CD14 mAb …
-
Plasma amino acid and metabolite changes in pigs during endotoxemia
… in plasma AA and their catabolism in response to endotoxemia. Area under the curve (AUC) was calculated for a selected AA to report AA balances. During the induction phase of an acute challenge (t = -2 to 12 h), analyzed AA were in a negative balance indicating heavy AA catabolism. However, during …
-
A Mechanism for the Metabolic and Inflammatory Alterations Associated with Low-dose Endotoxemia
… endotoxin levels has been termed metabolic endotoxemia and is beginning to be investigated in disease pathologies including insulin resistance and type II diabetes, atherosclerosis, cancer metastasis and Parkinson's disease. These disease phenotypes all possess a component of chronic …
-
A Combined In Vivo and In Vitro Approach to the Study of Endotoxemia in Swine
… old SPF-derived Yorkshire pigs, both because endotoxemia is a common and important swine problem, and because the pig is a good model for human adult respiratory distress syndrome. Physiological changes included sustained increases in mean pulmonary artery pressure, pulmonary vascular …
-
Cardiovascular and Hematological Effects of Hetastarch and Hypertonic Saline Solutions During Experimental Endotoxemia in Horses
Justification: Endotoxemia and sepsis are major causes of mortality in horses, resulting in significant economic losses for the equine industry. Objective: To determine the effects of the combination of Hypertonic Saline Solution and Hetastarch in endotoxemic horses. Animals: Eighteen horses …
-
The Role of IRAK-1 in the Regulation of Free Radicals and Oxidative Stress during Endotoxemia
… lesions in liver and kidney, and reduced endotoxemia-associated mortality. Taken together, IRAK-1 may, at least in part, serve as an important therapeutic target in the treatment of various inflammatory disease processes.
-
An investigation of the effects of diet on the gastrointestinal microbiota, inflammation, and metabolic endotoxemia in adults
… is through the prevention of metabolic endotoxemia, defined as a 2- to 3- fold increase in the circulating concentrations of the pathogen associated molecular pattern lipopolysaccharide (LPS). As the largest reservoir of LPS in the body, the GI microbiota represents an under-investigated …
-
Evaluation of Pgg-Glucan, a Novel Immunomodulator, in in Vitro and Ex Vivo Models of Equine Endotoxemia
Justification - Endotoxemia is an important contributor to mortality and loss of use in the horse and results in significant losses to the equine industry on an annual basis. Objective - To determine the effect of PGG-Glucan on the cytokine response to endotoxin in the horse. Animals - Part 1; 6 …
-
Characterization of an in vitro exercise model and the effects of a metabolic endotoxemia on skeletal muscle adaptation to electric pulse stimulation
The prevalence of obesity and type II diabetes is increasing. Although exercise is widely accepted for prevention and treatment, evidence of resistance to exercise in patients with these diseases is also mounting. Muscle contraction during exercise stimulate cellular responses important for …
-
Mecanismos moleculares da fibrose renal em ratos submetidos à inflamação durante o desenvolvimento : possíveis estratégias terapêuticas
A endotoxemia materna durante a gestação pode programar doença renal crônica (DRC) na prole adulta, além de torná-la mais sensível a insultos pós-natais. A fibrose renal é a principal característica da DRC e é resultante do desequilíbrio entre a produção/degradação de matriz extracelular (MEC). A …
-
The influence of equine bone marrow derived stem cells on the response of cultured peripheral blood mononuclear cells to endotoxin
Endotoxemia is a major cause of morbidity and mortality in horses. The presence of large amounts of circulating endotoxin inititates a number of cell signaling pathways leading to a systemic inflammatory response. Activation of these pathways causes the release of a number of pro- and …
-
Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide
Low dose endotoxemia is caused by several health conditions including smoking, alcohol abuse, high fat diets, and aging. Several studies have correlated low dose endotoxemia with increased risks of atherosclerosis, diabetes, and Parkinson's disease. Unlike high doses of endotoxin which induce a …
-
TLR4 expression on equine B lymphocytes: a clue to LPS sensitivity?
Horses are prone to potentially lethal endotoxemia due to their surrounding fecal containing environment and their predisposition to colic. Their gastrointestinal tract and feces naturally contain gram-negative bacteria. These bacteria express lipopolysaccharide (LPS) on their cell membranes, which …
-
Role of the dorsomedial and ventrolateral medulla in the regulation of pain sensitivity in the endotoxemic organism
… and body temperature regulation during endotoxemia. Micro-injections of glutamate or vanilloid receptor agonists in toxic concentrations into the nucleus tractus solitarii (NTS) and the caudal ventrolateral medulla (CVLM) lead to the similar effect. Both types of intervention – vagotomy, …
-
Sympathetic Neural Control of Inflammation by ADRB2-Mediated IL-10 Secretion
… an infection model, experimental colitis and LPS endotoxemia model. ADRB2-/- animals presented with splenomegaly and greater weight loss in infection and colitis, compared to ADRB2 sufficient animals, respectively. ADRB2-/- animals rapidly succumbed to a sub-lethal LPS challenge, which correlated …
-
Signaling Cross-Talk Regulating the Expression of Arginase 1 in Murine Macrophages
… bacteria, and a potent pyrogen. In metabolic endotoxemia, LPS concentration in the blood is slightly elevated, and over the long term this contributes to diverse inflammatory diseases such as atherosclerosis, obesity, and diabetes. LPS promotes the M1 phenotype and suppresses the M2 phenotype, …
-
Diet and exercise modulate the gut microbiome with implications for health and disease
… insulin sensitivity, inflammation, and metabolic endotoxemia in previously sedentary, lean and obese humans, and how these correlated with already published effects of the exercise intervention on the gut microbiota and microbial metabolites. We found that exercise training reduced insulin …
Page 1 of 3