Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 102 for “"endothelin"”.
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Studies of the mammalian ovarian endothelin system
In porcine ovaries, endothelin-1 (ET-1) may have an autocrine/paracrine role in follicular development. Endothelin-converting enzyme-1 (ECE-1) converts big endothelin-1 to ET-1. In situ hybridization was used to determine the ovarian compartment that synthesizes ECE-1. ECE-1 mRNA was detected in …
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P27 Expression in Endothelin-1 Stimulated Mitogenesis
… been shown in our lab to synthesize and secrete endothelin-1 (ET-1). The endothelin-1 binds ETA receptors, this elevates intracellular calcium, stimulate DNA replication and cell division. This investigation explores ET-l's role as a mitogenic factor in corneal endothelial cells and addresses …
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Investigating endothelin receptor B signalling during myelination
… receptor (GPR) superfamily members. One GPR, Endothelin receptor B (EDNRB), best known for regulating blood flow, had previously been demonstrated to both positively and negatively influence myelination. I have investigated how EDNRB regulates myelination using an in vitro myelination assay, …
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The role of endothelin-2 in ovulation
… maintenance. Just prior to ovulation, the gene endothelin-2 (Edn2) is highly yet transiently expressed for a two-hour window. Mature endothelin-2 protein (EDN2) is a 21 amino acid peptide that is classically described as a potent vasoconstrictor. EDN2 is produced exclusively by the granulosa …
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The Physiological Function of Endothelin-2 in Mice
In order to directly explore the physiological function of ET-2, we generated constitutive, tissue-specific and systemically inducible knockout mice. Global ET-2 deficient mice exhibited severe growth retardation and juvenile lethality. Despite normal milk intake, they suffered from an apparent …
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Endothelin system in human cardiovascular physiology and pathophysiology
… the pharmacology and physiology of the endothelin (ET) system in human blood vessels in health, and the influence of cardiovascular disease on the ET system. This work followed from the discovery of ET-1 as a peptide endothelial mediator of vascular tone in 1988. Publications are grouped …
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Evolution of Endothelin Signaling and Diversification of Adult Pigment Patterns
… approaches we identify the secreted peptide Endothelin-3 (Edn3)—a known melanogenic factor of tetrapods—as contributing to reduced iridophore proliferation and fewer stripes and interstripes in D. nigrofasciatus. We further show the locus encoding this factor is expressed at lower levels in …
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Importance of MAPK and PKC in cerebrovascular endothelin receptor changes
Endothelin is a vasoactive peptide that exerts its effect through two receptors; the endothelin type A (ETA) and type B (ETB) receptor. The contractile ETA receptor is localized on smooth muscle cells in the vascular wall, while the ETB receptors are mainly situated on endothelial cells, mediating …
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Vascular Endothelin and Angiotensin Receptors Regulation in Inflammatory Arterial Disorders
… correlates with the expression of vascular endothelin and angiotensin receptors. The receptor changes were studied in subcutaneous resistance arteries in patients with different degrees of ischemic heart disease (IHD). In addition, patients with giant cell arteritis (GCA) were also …
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The electrophysiological effects of Endothelin-1 in human atrial myocytes
… (AF) and elevated levels of catecholamines and endothelin-1 (ET-1), each of which affects the atrial L-type calcium current (ICaL) and consequently action potentials. Hypotheses: ET-1 modulates the effects of isoproterenol (ISO) on ICaL and action potentials in human atrial myocytes. Methods: …
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Modulation of the Cardiomyocyte Hypertrophic Responses to Endothelin-1 by Adipocytes
… between the adipocytes and cardiomyocytes during endothelin-1 (ET-1)-induced cardiomyocyte hypertrophy and determine the role of leptin and adiponectin. The adipose tissue conditioned medium (ACM) inhibited the ET-1-induced hypertrophy in a concentration-dependent manner and this anti-hypertrophic …
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Endothelin-1 and Hypoxic Vascular Remodeling in Ovine Fetal Cerebral Arteries
… as Vascular Endothelial Growth Factor (VEGF) and Endothelin-1 (ET-1), which rises and falls with HIF levels. The absence of chronic elevation of these ligands prompted the question of how long-term effects of hypoxia is sustained. Results suggest that in addition to stimulating transient rises in …
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Endothelin-1 Induced Phosphorylation of ERK1/2 in Bovine Corneal Endothelial Cells
… purpose of this study was to determine whether Endothelin-1 (ET-1) induced cellular responses in bovine corneal endothelial cells (BCECs) involves MAPK pathway by phosphorylating ERK1/2 protein kinase and to find out the phosphorylation patterns of ERK1/2 in confluent and sub-confluent cells. …
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Perinatal Hypoxia Exposure on the Developing Heart: The Role of Endothelin-1
… premature infant, and leads to the production of endothelin-1. Our study aims to test the hypothesis that perinatal hypoxia exposure induces a premature terminal differentiation of cardiomyocytes, focusing on the role of endothelin-1 and the underlying epigenetic and molecular mechanisms. We …
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