Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 13 of 13 for “"endothelialisation"”.
-
Promoting endothelialisation to reduce vascular injury following coronary angioplasty and stent implantation
… identify novel polymer substrates that promote endothelialisation of coronary stents. Furthermore, I evaluated the potential of a novel cyclin-dependent kinase (CDK) inhibitor (AT7519) to resolve the acute neutrophil-mediated inflammatory response to stenting without adversely affecting the …
-
Use of poly vinyl alcohol (PVA) cryogelation for tissue engineering: composites, scaffold formation and cell encapsulation
… shear stress could be used to facilitate endothelialisation of the PVA cryogel surface. The results demonstrated that, the two step gel formation method was beneficial for degradation resistance and mechanical properties. All composites used supported cell attachment and proliferation, …
-
The molecular mechanisms of diabetes mediated impaired wound healing and the development of therapeutic strategies.
… of the wound healing assay revealed that re-endothelialisation occurs faster (p < 0.001) than endothelialisation. The effects of hypoxia and high glucose concentration appeared to be mediated via PI3K-Akt and PKC-beta-II pathways respectively. Further investigations revealed the possibility …
-
Electrospun Tissue Engineered Vascular Grafts
… current synthetic grafts. Spontaneous transmural endothelialisation can be enhanced in non-degradable scaffolds with heparin-mediated growth factor delivery via heparin surface modification, as well as induce an anti-thrombotic lumen. Electrospinning of vascular grafts offer a means to mimic the …
-
Electrospun Tissue Engineered Vascular Grafts
… current synthetic grafts. Spontaneous transmural endothelialisation can be enhanced in non-degradable scaffolds with heparin-mediated growth factor delivery via heparin surface modification, as well as induce an anti-thrombotic lumen. Electrospinning of vascular grafts offer a means to mimic the …
-
Funktionalisierung von Polydimethylsiloxan-Oberflächen zur Steuerung molekularer Zell-Substrat Wechselwirkungen
… CM-dextran or starPEG. Investigations of the endothelialisation behaviour of human as well as porcine endothelial precursor cells (EPCs) from the whole blood showed that the modified surfaces are able to selectively bind EPCs and hence to promote a specific endothelialisation of the synthetic …
-
Langzeituntersuchung zur In-Stent-Restenose eines neuen biodegradierbaren, wirkstoffbeladenen, intravaskulären Polylaktidstents nach Implantation in porcine Koronararterien
… after 3 weeks or 3 months. Early complete endothelialisation was shown. Nevertheless, a local inflammatory response to the polylactide as a result of the polymer resorption process was observed. This novel polylactide stent showed sufficient mechanic stability, and by incorporation of …
-
A system for impedance characterization of coronary stents
… Much research has been carried out to monitor endothelialisation of the stent-tissue interface using invasive methods, but such methods are commonly only suitable for in vitro studies (Prasad et al, 2005), meaning they cannot be practically used clinically and can only provide information at a …
-
Leukocyte Response to Elastin-Like Polypeptide Coatings
… the development of materials that support endothelialisation and protein modification to the material surfaces that reduce thrombosis. The extracellular matrix protein elastin has been found to be one of the least thrombogenic components of blood vessels, and its purified and recombinant …
-
Patient-specific thoracic endovascular aoratic repair (TEVAR)
… of 7.5 µm; pore size indicates possibility of endothelialisation. Nitinol reinforced patient-specific graft was successfully made and stent-grafts of various stent patterns had radial forces between 1.3 to 5.8 N (comparable to 2.8 N from a commercial example). FEA simulation highlighted various …
-
Stimulating angiogenesis into biomaterials through the delivery of growth factors
… are needed. The concept of transmural in vivo endothelialisation of vascular grafts holds great promise for increasing long term patency. To achieve complete luminal endothelial cell coverage and optimal integration of the porous synthetic graft material into the host tissue, transmural …
-
Stabilised decellularised vascular grafts in an ovine carotid model
… decellularised vascular grafts failed to achieve endothelialisation or patency in this sheep carotid model. Significant calibre mismatch between the test graft and the native artery is thought to be the primary factor in the failure of these grafts, highlighting the potential difficulty in …
-
Biokompatibilitätsuntersuchung von Conduits für den Pulmonalklappenersatz
In der vorliegenden Arbeit wurde an einer humanen Präparate-Serie von 24 aus dem rechtsventrikulären Ausflusstrakt explantierten Conduits die zelluläre und extrazelluläre Gewebereaktion auf die Implantate untersucht. Die histopathologische Auswertung der Homografts, Rindervenengrafts und Hancock- …