Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 36 for “"endothelial nitric oxide synthase"”.
-
Regulation of Endothelial Nitric Oxide Synthase in Pulmonary Myofibroblasts
… matrix deposition commonly seen in IPF. The nitric oxide (NO) signaling pathway is implicated in protomyofibroblast to myofibroblast transition and regulation. Previous work has shown that in pulmonary myofibroblasts, endothelial nitric oxide synthase (eNOS) is the primary NOS isoform …
-
Characterization of Endothelial Nitric Oxide Synthase Serine-600 Phosphorylation
<p>Endothelial nitric oxide synthase (eNOS) is part of a family of three nitric oxide synthase (NOS) enzymes that catalyze the production of nitric oxide (NO). NO is a gaseous, free-radical signaling molecule that has a variety of cellular and physiological functions that range from maintaining …
-
UNDERSTANDING HOW MAP KINASES INFLUENCE ENDOTHELIAL NITRIC-OXIDE SYNTHASE ACTIVITY
… p38 and ERK have both been reported to bind endothelial nitric oxide synthase (eNOS) with submicromolar affinity via proposed interactions with a pentabasic non-canonical MAPK binding sequence in the autoinhibitory insertion of eNOS. The neuronal isoform, which lacks the pentabasic motif, did …
-
Endothelial Nitric Oxide Synthase and Growth Factor Regulation of Flow-Mediated Vascular Remodeling
<p>This study was designed to characterize structural remodeling of male Wistar rat mesenteric arteries exposed to elevated blood flow in vivo for 1, 3, or 7 days. A series of arterial ligations induced blood flow increases in ileal and second-order branch arteries compared to same animal control …
-
The role of Zinc and Reactive Oxygen Species in the Regulation of Endothelial Nitric Oxide Synthase
… to a decrease in the activity and expression of endothelial nitric oxide synthase (eNOS). Thus, it is critical to understand the mechanisms by which eNOS is regulated to identify new pathways and novel therapies for PPHN. eNOS is dynamically regulated at the transcriptional, post-transcriptional, …
-
The role of Zinc and Reactive Oxygen Species in the Regulation of Endothelial Nitric Oxide Synthase
… to a decrease in the activity and expression of endothelial nitric oxide synthase (eNOS). Thus, it is critical to understand the mechanisms by which eNOS is regulated to identify new pathways and novel therapies for PPHN. eNOS is dynamically regulated at the transcriptional, post-transcriptional, …
-
Assessment od Adiponectin and Endothelial Nitric Oxide Synthase levels in Black Zambian patients with Hypertension at the University Teaching Hospital, Lusaka
… and this might be due to its effects on endothelial nitric oxide synthase levels. Aims - In this study we aimed to assess plasma adiponectin and endothelial nitric oxide synthase in patients with hypertension.Methods and Results - An analytical cross-sectional study was undertaken in …
-
The mechanism(s) of post-transcriptional regulation of the human constitutive endothelial nitric oxide synthase gene by tumor necrosis factor-alpha
Endothelial nitric oxide synthase (eNOS) is an enzyme that catalyzes the formation of nitric oxide (NO) from the amino acid L-arginine and molecular oxygen, with the help of cofactors and a heme iron. It is one of three isoforms discovered as yet, and was first identified in endothelial cells …
-
Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function
… factor-[Beta][ (TGF-[beta]), prostacyclin, and endothelial nitric oxide synthase (eNOS). siRNA inhibition of connexin 43 in porcine aortic endothelial cells (PAEC) significantly decreased the diffusion distance of Lucifer yellow dye and cytoplasmic calcium levels after mechanical wounding. Wound …
-
Long-Term Hypoxia Alters Ovine Fetal Adrenal eNOS and Cortisol Biosynthesis
… production in response to a secondary stress. Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS) in the adrenal cortex, plays a significant role in regulating cortisol production in the LTH fetus. The production of NO is regulated by eNOS activity which can be altered via …
-
Going With The Flow: Selective phosphodiesterase 4D7 (PDE4D7) regulation of vascular endothelial cell responses to fluid shear stress
Vascular endothelial cells (VECs) regulate their phenotype in response to the frictional force exerted by the flowing blood, fluid shear stress (FSS). The hemodynamics dictating this force determine, to a large extent, the likelihood that a given region of a blood vessel will develop …
-
Sex differences in mesenteric endothelial function of streptozotocin-induced diabetic rats: The role of endothelium-derived relaxing factors
… the mesenteric expression of the mRNAs for endothelial nitric oxide synthase (eNOS) and NADPH oxidase (Nox) in STZ-induced diabetes in both sexes. Vascular responses to acetylcholine (ACh) in mesenteric arterial rings pre-contracted with phenylephrine were measured before and after …
-
Investigating the impact of flavonoid metabolites on endothelial function and vascular inflammation
… on vascular and inflammatory biomarkers of endothelial dysfunction. 20 flavonoids and metabolites were screened for their effects on endothelial nitric oxide synthase (eNOS), haem oxygenase-1 (HO-1/Hmox-1), and vascular cell adhesion molecule-1 (sVCAM-1) in endothelial and smooth muscle …
-
Novel Strategies in Cardioprotection against Ischemia/Reperfusion Injury
… mediators including adenosine, bradykinin or nitric oxide (NO), that may trigger a signaling cascade leading to protection against I/R injury. Our results show that sildenafil, at a clinically relevant dose, induced powerful acute and delayed cardioprotection against I/R injury in an in vivo …
-
Biological activity of anthocyanins and their phenolic degradation products and metabolites in human vascular endothelial cells
… and ascorbic acid) were screened in a human endothelial cell model for effects on endothelial nitric oxide synthase (eNOS) activity (via ELISA & colourimetric assay), and NADPH oxidase (NOX)-mediated superoxide production (by cytochrome c reduction assay, optimised in-house). A bioactive …
-
Development and Characterization of Tissue Engineered Blood Vessel Mimics Under "Diabetic" Conditions
… occurring in the blood vessels, primarily endothelial dysfunction. This thesis aimed to create a diabetic blood vessel mimic by implementing a high glucose environment for culturing human endothelial cells from healthy umbilical veins (HUVECs) and from diabetic coronary arteries (DHCAECs). …
-
Physiological Implications and Mechanisms of Estrogen Protection Associated With Myocardial Ischemia /Reperfusion Injury
… estrogen receptor antagonist (ICI 182,780), or endothelial nitric oxide synthase (eNOS) antagonist (L-w-nitro-L-arginine (L-NNA)) at appropriate times prior to E2 (5 mug/kg) that was administered 30 min before removal of the heart for mounting in a modified Langendorff apparatus. After …
-
The effect of single nucleotide polymorphisms of oxidative stress genes and low grade inflammation upon pulse wave contour analysis, a useful non invasive, intermediate vascular phenotype.
… Oxidative stress, within which, inactivation of nitric oxide (NO) by superoxide (SO) and other reactive oxygen species is characteristic. Two major enzyme systems are implicated within oxidative stress; NAD(P)H oxidase and endothelial nitric oxide synthase (eNOS). eNOS generates NO while at the …
-
THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
… matrix components through MMP's. In addition, endothelial cell caveolae are known to localize the Ang-II (AT1) receptor and regulate renin-angiotensin signaling. Based on these findings, we evaluated the role of caveolae in AAA formation in the murine model. Here, eight week old mice were …
Page 1 of 2