Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 139 for “"endothelial dysfunction"”.
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ATHEROSCLEROSIS AND ENDOTHELIAL DYSFUNCTION IN THALASSEMIA
… patients, linking them to cardiovascular risk, endothelial function, and iron/heme parameters. Methods included clinical data, biochemical analysis, T2* MRI for iron overload, and carotid Doppler ultrasounds for plaque detection and intima-media thickness. Inflammatory and endothelial markers …
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Endothelial dysfunction as a pathogenetic factor in cardiovascular diseases
… and documented, but one crucial element is endothelial dysfunction. Endothelial dysfunction is defined by the reduction of NO-induced vasodilation. The strongest link between endothelial dysfunction and CVD is atherosclerosis. The relationship between endothelial dysfunction and CVD has been …
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Obesity and endothelial dysfunction: mechanisms, method development and interventions
The principle aims of this thesis were to determine the effect of lowering plasma fatty acids (FA) on muscle microvascular blood volume (MBV) at rest and during exercise, investigate whether near-infrared spectroscopy (NIRS) can be used to measure muscle MBV in the obese, develop the contrast …
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PALMITATE INDUCED ENDOTHELIAL DYSFUNCTION: THE ROLE OF CALPAIN, AMPK AND ENOS
… of adipose tissue inflammation found in obesity. Endothelial adhesion molecules up-regulation contributes to leukocyte infiltration during inflammation. Some clinical data suggested an increase of leukocyte-endothelium interaction in healthy volunteers after ingestion of high-fat meals …
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¿ROLE OF ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF UNPROVOKED VENOUS THROMBOEMBOLISM¿
… the development of novel therapeutic strategies. Endothelial dysfunction (ED) plays a crucial role in promoting thrombus formation, yet its presence in uVTE patients has been poorly investigated, so far. Therefore, in this study we investigated ED in uVTE, using patient-derived endothelial …
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Cardiorespiratory fitness as a cardiovascular protective mechanism of endothelial dysfunction with aging
… a key mechanism underlying age-related vascular endothelial dysfunction. Aerobic exercise with aging leads to improvements in cardiorespiratory fitness (CRF) and preserves endothelial function in preclinical models via lower mitochondrial-derived ROS (mtROS) however, these effects have yet to be …
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Investigating nutrient excess and endothelial dysfunction: a role for BACE1 and amyloid?
<b>Background</b>: Endothelial dysfunction (ED) often occurs secondary to metabolic pathologies associated with nutrient excess, such as hyperglycaemia and dyslipidaemia. ED, characterised by reduced nitric oxide (NO) bioavailability and activity, and inflammation, is associated with cardiovascular …
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Circulating progenitor cells in atrial fibrillation: Relationship to endothelial dysfunction, thrombogenesis and inflammation
… confers a hypercoagulable state. Disruption of endothelial homeostasis (damage vs. repair) is thought to be central to this process. The endothelium appears to be damaged both by AF and various other vascular diseases (e.g. hypertension) that frequently co-exist with the arrhythmia, with similar …
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Thermal-based probe for testing endothelial dysfunction and possible implications for diagnosing atherosclerosis
Endothelial dysfunction is a precursor to atherosclerosis. Thus, the vascular health of an individual can be assessed if endothelial dysfunction can be readily and unambiguously quantified. A thermal-based approach using temperature and blood perfusion measurements in conjunction with an arterial …
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Systemic Cytokine Expression and Endothelial Dysfunction: Insights from Innate Immune Models of Protein Phosphorylation
… and transmigrating monocytes into the sub-endothelial space. The local recruitment of inflammatory cells and release of pro-inflammatory mediators induces endothelial dysfunction, an early functional abnormality in CVD. Plasma cytokines have been used to stratify CVD risk in humans. Studies …
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Assessing Endothelial Dysfunction Estimating the Differences Between 3 Minute and 5 Minute Reactive Hyperemia
… time to induce reactive hyperemia in assessing endothelial dysfunction. In this study, strong evidence was found by a novel technique that used oscillometric methods, which supported that 3 minute reactive hyperemia was sufficient to elicit a significant difference in arterial compliance from …
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Value of Raisins for Reduction of Oxidative Stress, Endothelial Dysfunction, and Inflammation in Obesity
… on markers of inflammation, oxidative stress and endothelial activation in response to an acute high-fat meal in obese individuals. Seventeen overweight men and women consumed raisins or placebo (264 kcal/d) for 14 d in a randomized cross-over design while following a low-flavonoid, …
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The Role of Lipoprotein(a)/Apolipoprotein(a) in Endothelial Dysfunction: Mechanistic Studies in Vascular Endothelium
… suggested a role for Lp(a) in the process of endothelial dysfunction. Indeed, Lp(a) has been shown to increase both the expression of adhesion molecules on endothelial cells (EC), as well as monocyte and leukocyte chemotactic activity in these cells. We have previously demonstrated that Lp(a), …
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Endothelial progenitor cells, uraemic toxins, and the development of endothelial dysfunction in chronic kidney disease.
… the increased risk, with novel factors causing endothelial dysfunction (ED), leading to arteriosclerosis, congestive heart failure (CHF) and sudden death, key to disease pathogenesis. These novel factors include bone marrow (BM) derived endothelial progenitor cells (EPCs), which have key roles …
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Design of a thermal diffusion sensor for noninvasive assessment of skin surface perfusion and endothelial dysfunction
… complications, increasing evidence shows that dysfunctional vasoreactivity in the skin microcirculation is associated with multiple disease states, including hypertension, diabetes mellitus, hypercholesterolemia, peripheral vascular disease, and coronary artery disease, and it is one of the …
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The Influence of Obstructive Sleep Apnea Syndrome on Insulin Resistance, Metabolic Syndrome, and Endothelial Dysfunction in Young Men
… of insulin resistance, MetS, and vascular endothelial dysfunction (VED) exists in young, overweight men with OSAS and if the combined effects of obesity and OSAS augments the evidence of chronic disease pathogenesis beyond the effects of obesity alone. Subjects: Subjects were 12 overweight …
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Effect of acute exercise on postprandial lipemia and biomarkers of endothelial dysfunction and inflammation in normal weight and overweight adolescents
… lipemia (PPL) is associated with impaired endothelial function, an increase in adhesion molecule expression and inflammation. Acute exercise reduces PPL in adults. No studies have examined the effect of acute exercise on PPL in normal weight (NW) and overweight (OW) adolescents. PURPOSE: To …
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Antioxidant and phenolic characterization, bioavailability and protective effects under oxidative stress and endothelial dysfunction of a red wine pomace seasoning (RWPS)
Los orujos son los principales subproductos generados por la industria vitivinícola, suponiendo un problema medioambiental y de gestión en las bodegas. Sin embargo, estos residuos de vinificación presentan un gran potencial en el desarrollo de nutracéuticos e ingredientes funcionales alimentarios …
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