Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"endothelial cell function"”.
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ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… is poorly understood. We discovered in cultured endothelial cells that ApoE3 activates endothelial NO synthase (eNOS) and thereby stimulates endothelial cell migration, and that both processes require ApoER2. In contrast, ApoE4 is incapable of activating eNOS and in fact blunts ApoE3 activation …
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Metabolic regulation of human vascular endothelial cell function in vitro
… such as endothelin-1 and thromboxane A2. Endothelial NO is the principal vasodilator in the vasculature and is produced by endothelial nitric oxide synthase (eNOS). Insulin is a vasoactive hormone that exerts its vasodilatory effects through eNOS-mediated NO production. Endothelial …
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The effect of scaffold physical properties on endothelial cell function
Endothelial cells (EC) are ubiquitous - as vascular epithelial cells they line the inner surface of all vessels and are the contact surface with flowing blood. Macrovascular EC are the first line barrier between flowing blood and mural structures. The microvasculature includes EC-lined vessels that …
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MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
… restore the supply of oxygen and nutrients tumor cells activate a variety of adaptive mechanisms. Among them, hypoxia-induced angiogenesis, i.e. the formation of tumor blood vessels from pre-existing vasculature, has proved to be of critical importance, and has led to the development of …
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Regulation of specific connexins differentially alters gap junction permeability and endothelial cell function
… gap junction connexin proteins in regulating cellular communication and wound healing. Using RNA interference or peptide inhibitors to downregulate specific connexins we examined the role of gap junctions in intercellular diffusion, calcium excitation, and in mediating the expression of …
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The Roles of the Collagen Binding Integrins in the Regulation of Endothelial Cell Function
… to then assess their role in the regulation of endothelial cell (EC) behaviour using human umbilical vein endothelial cells (HUVECs). First, quantitative real-time polymerase chain reaction (qPCR) was performed to quantify the expression levels of the four integrins. Functional roles of these …
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Vascular Effects of Low-Molecular Weight Heparin in Pregnant Women at High-Risk of Preeclampsia
… first experiment was to assess cardiovascular function in pregnant women at high-risk of PE compared with low-risk pregnant controls at 24 weeksâ gestation. High-risk women demonstrated a lower cardiac output, higher resistance hemodynamic profile with impaired radial artery flow-mediated …
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Bioenergetic and functional impacts of glucose, fructose and insulin in endothelial cells:: implications for cardiovascular disease in diabetes
… and mortality in patients with diabetes. Endothelial dysfunction is recognised to be a key early event in the atherogenic process that underpins vascular disease, and endothelial hyperglycaemic exposure or excursion could underpin this process. In addition, increased fructose consumption …
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Promoting endothelialisation to reduce vascular injury following coronary angioplasty and stent implantation
… artery disease. I sought to establish a new cellular model to study the coronary endothelium in patients with acute myocardial infarction, and to utilise this model to identify novel polymer substrates that promote endothelialisation of coronary stents. Furthermore, I evaluated the potential …
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The Role of adipokines in obesity related beta-cell failure of diabetes mellitus and endothelial cell dysfunction of cardiovascular diseases.
… and more recently studies have shown that fat cells produce proteins called adipokines which have various influences on the human metabolism and has helped to change the perspectives of researchers on the concept of the adipose tissue being just a store of energy. As a result of this, …
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Metabolism in Vascular Endothelial Cells: Effects of Hyperglycaemia, Pro-Inflammatory Cytokines and Polyphenols
… on the vascular endothelium by modulating endothelial cell metabolism. Results: First, the effects of high-glucose concentrations, inflammatory cytokines and polyphenols on markers of endothelial cell function in HUVECs were explored. Hyperglycaemic conditions did not significantly affect …
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Platelet micro-particles induce angiogenesis through the delivery of the micro-RNA Let-7a into endothelial cells
… is impaired anti-thrombotic and antiinflammatory functions of the endothelium. Thrombosis is a hallmark of cardiovascular disease/complications characterised by increased platelet activation and increased secretion of platelet micro-particles that induce angiogenesis. This study determined the …
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Role of ANLN in post ischaemic angiogenesis
… new blood vessels are dynamically formed in Endothelial cell (EC) driven processes. The identification of new potential genes of interest in ECs can help to further understand the underlying mechanisms of angiogenesis and help develop new therapeutic strategies for cardiovascular disease. One …
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Fibromodulin and Dystrophin in Atherosclerosis: Novel roles for extracellular matrix in plaque development
… composition and integrity of a dynamic extracellular matrix (ECM) is one very important factor. This thesis discusses the importance of the connection between the ECM and cells for atherosclerotic lesion development. It also tests the hypothesis that changes in this connection – whether …
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Improvement of liver transplantation by reducing preservation-reperfusion injury
… Hyaluronic acid levels were used as markers of endothelial cell function. Serum AST was used as a marker of hepatocellular injury. In summary, these studies showed that there was a significant reperfusion injury after portal venous reperfusion with no additional injury after rearterialization. …
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Development and Evaluation of 3D-Printed Cardiovascular Stents
… with resveratrol (RSL) to efficiently recover endothelial cell function. The biocompatibility of the 3D-printed stent was evaluated using in vitro cell culture studies and zebrafish embryo model. The percentage changes in volume of stents fabricated using HEMA and HEMA-0.35MeGO were 36.7±4.7% …