Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 364 for “"endothelial cell"”.
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Vascular endothelial cell-surface proteoglycans
… linked by disulfide bonding was isolated from cell layers of normal ("cobblestone") bovine vascular endothelial cells in culture. Treatment of the parent molecules with dithiothreitol caused their complete cleavage and permitted the subsequent separation of the larger and smaller subunits on …
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Modelling the endothelial cell response to fluid flow
In vitro endothelial cells respond to fluid flow by elongating in the direction of flow. How the mechanical signal is transformed into an organised and directed response is poorly understood. The most studied and crucial aspects to this response are; actin filament alignment, mechano-transduction, …
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Evaluation of Endothelial Cell Responses to Elevated Glucose
… model, this thesis assessed Human Umbilical Vein Endothelial Cell (HUVEC) responses to high glucose conditions. Interleukin 6 (IL-6) and Cluster of Differentiation 36 (CD36) were selected to signify oxidative stress activity, a hallmark of diabetic macrovascular disease. Next, activity of …
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Chronic Shear Stress Effects on Endothelial Cell Response
… secretion of important regulatory molecules by endothelial cells. Our hypothesis was that inclusion of chronic pulsatile shear stress in our model would lead to changes in endothelial cell release of regulatory molecules. We distinguished between high arterial shear stresses and low venous shear …
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ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… is poorly understood. We discovered in cultured endothelial cells that ApoE3 activates endothelial NO synthase (eNOS) and thereby stimulates endothelial cell migration, and that both processes require ApoER2. In contrast, ApoE4 is incapable of activating eNOS and in fact blunts ApoE3 activation …
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Organ-specific heterogeneity in the endothelial cell hypoxia response
… hypoxia response pathways within microvascular endothelial cells. In the first results chapter I investigated the differential role of the two hypoxia inducible transcription factors HIF-1α and HIF-2α in the murine lung endothelium during cancer metastasis, and how the hypoxia response of the …
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The effect of angiostatin on the endothelial cell cycle
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Molecular Basis of HDL-Mediated Endothelial Cell Migration and Reendothelialization
… protection are unclear. The disruption of endothelial monolayer integrity is an important contributing factor in multiple vascular disorders, and vascular lesion severity is tempered by enhanced endothelial repair. In these studies we show that HDL stimulates endothelial cell migration in …
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Synergism of Gingipains in Endothelial Cell Adhesion Disruption and Apoptosis
… To explore the effects of these proteases on endothelial cells, we exposed bovine coronary artery endothelial cells (BCAEC) and human microvascular endothelial cells (HMVEC) to gingipain-active extracellular protein preparations and/or purified gingipains from <em>P. gingivalis. </em>Treated …
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Metabolic regulation of human vascular endothelial cell function in vitro
… such as endothelin-1 and thromboxane A2. Endothelial NO is the principal vasodilator in the vasculature and is produced by endothelial nitric oxide synthase (eNOS). Insulin is a vasoactive hormone that exerts its vasodilatory effects through eNOS-mediated NO production. Endothelial …
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Brain microvascular endothelial cell dysfunction in schizophrenia: a preliminary report
… of schizophrenia (SZ). Brain microvascular endothelial cells (BMECs) have paracellular and transcellular proteins, transporters, as well as important extracellular matrix proteins, which collectively contribute to maintaining proper BBB function. While previous studies have provided some …
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Pipeline for semi-automatic segmentation of confluent endothelial cell membranes
Changes in cell morphology are important indicators of underlying biological changes. As endothelial cells (EC) heterogeneously respond to stimuli, we seek to quantify EC morphologic heterogeneity and relate it to transcriptome phenotypes; however, existing semi-automatic methods for quantifying …
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The effect of scaffold physical properties on endothelial cell function
Endothelial cells (EC) are ubiquitous - as vascular epithelial cells they line the inner surface of all vessels and are the contact surface with flowing blood. Macrovascular EC are the first line barrier between flowing blood and mural structures. The microvasculature includes EC-lined vessels that …
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Role of CD44 in Immune Functions and Endothelial Cell Injury
… to the antigen-specific receptors, the T and B cells also express a variety of adhesion molecules, which are known to participate in cell-cell interaction, migration, homing and signal transduction. CD44 is a widely distributed cell surface glycoprotein whose principal ligand has been identified …
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MOLECULAR ASPECTS OF ENDOTHELIAL CELL FUNCTION AND HYPOXIA-DEPENDENT TUMOR ANGIOGENESIS
… restore the supply of oxygen and nutrients tumor cells activate a variety of adaptive mechanisms. Among them, hypoxia-induced angiogenesis, i.e. the formation of tumor blood vessels from pre-existing vasculature, has proved to be of critical importance, and has led to the development of …
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Endothelial cell impact on smooth muscle cell properties: role of hemodynamic forces
The vascular endothelium is a dynamic cell monolayer located at the interface of the vessel wall and bloodstream, where it regulates the physiological effects of humoral and hemodynamic stimuli on vessel tone and remodelling. Hemodynamic forces are of particular interest and include shear stress, …
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CD151 Reinforces Vascular Stability by Balancing Endothelial Cell Adhesion and Cytoskeletal Tension
<p>Tetraspanin CD151 is highly expressed in endothelial cells and regulates pathological angiogenesis. However, the mechanism by which CD151 promotes vascular morphogenesis and whether CD151 engages other vascular functions are unclear. We observed that CD151 is required for the maintenance of …
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Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retina
… result in severe vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, which is significantly impacted by the diabetic milieu. It has now been established that the endothelium relies on glycolytic metabolism predominantly for ATP generation, however …
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