Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"endothelial barrier"”.
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The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
… Cx43/ZO1 association in regulation of epithelial/endothelial barrier function. Using both in vitro and ex vivo methods of barrier function measurement, including Electric Cell-Substrate Impedance Sensing(ECIS), a TRITC-dextran transwell permeability assay, and a FITC-dextran cardiovascular leakage …
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Engineering the tumor microenvironment using microfluidics : effects of cell-cell interactions and endothelial barrier function on tumor cell intravasation
… cell motility combined with quantitation of the endothelial barrier function. Compared with traditional in vitro assays, microfluidic assays enable "user-defined" design of the cellular and acellular microenvironment with spatio-temporal control and live high-resolution imaging. Formation of …
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Molecularly Targeted Nanoparticles for Modulation of Inflammatory Mediators in Atherosclerosis
… to demonstrate an inverse relationship between endothelial barrier integrity and propensity for thrombosis. We show that increased exposure of an atherosclerotic animal to an inflammatory stimulus (e.g. cholesterol) over time decreases endothelial barrier integrity and increases …
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Role of Trp Channels In Mediating The Calcium Signaling Response of Brain Endothelial Cells to Mechanical Stretch
… often results in disruption of the blood brain barrier (BBB), which is an integral component to maintaining the central nervous system homeostasis. Recently cytosolic calcium levels ([Ca<sup>2+</sup>]i), observed to elevate following TBI, have been shown to influence endothelial barrier …
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An Optogenetic Toolbox for the Interrogation of Dynamic Events During Angiogenesis
… LightR-VEGFR2 regulation was perturbed in endothelial cells. These findings highlight the challenges in the creation of LightR-RTKs but also provide a logical foundation for their creation. Another immediate consequence of angiogenic stimulation is rapid alteration of the endothelial …
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Tumor cell extravasation in an in vitro microvascular network platform
… networks. Vasculatures developed exhibit tight endothelial cell-cell junctions, basement membrane deposition and physiological values of vessel permeability. Employing our assay, we demonstrate impaired endothelial barrier function and increased extravasation efficiency with inflammatory …
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Role of Sodium Arsenite in Atherogenesis
… C (PKC) isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the endothelial barrier. Accordingly, exposure of ApoE-/- /LDLr-/- mice to As(III) in drinking water showed an increasing trend in atherosclerotic …
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Role of Sodium Arsenite in Atherogenesis
… C (PKC) isotypes, α and β, in human aortic endothelial cells (HAECs) and (3) determining the effects of activation of PKC isotypes, α and β, on the endothelial barrier. Accordingly, exposure of ApoE-/- /LDLr-/- mice to As(III) in drinking water showed an increasing trend in atherosclerotic …
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Modulatory effect of EVOO polyphenols and their metabolites on inflammatory response in Adenocarcinoma Colon Cells (Caco-2) and Human Umbilical Vein EC (HUVEC)
… that alters structure and functionality of the endothelial and intestinal barrier. EVOO(EVOO), the main lipid source in the Mediterranean diet, is rich in bioactive compounds mainly hydroxytyrosol (HT) and tyrosol (Tyr), that have been shown to possess antimicrobial, antioxidant and …
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Tie-ing the endothelium: development of an mRNA-based nanotherapeutic to restore microvascular barrier function for the treatment of sepsis-induced multiple organ failure
… novel therapeutic approaches to treat sepsis. Endothelial dysfunction is a hallmark of sepsis to which the loss of Ang/Tie2 signalling, a key regulator of vascular integrity, contributes significantly, making it an attractive therapeutic target. The impairment in Tie2 pathway activity manifests …
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Host-Defense Function of Anuclear Polymorphonuclear Neutrophil in Lung Injury
… to PMN and the ability to migrate across the endothelial barrier, phagocytosis of bacteria, and bactericidal activity. Adoptive transfer of PMNcyto into Pseudomonas aeruginosa (PA) infected mice showed a markedly reduced inflammatory lung injury. Unlike PMN, the host defense function of …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
… options. Increasing evidence identifies endothelial dysfunction and vascular barrier disruption as central drivers of ARDS pathogenesis, particularly in the context of SARS-CoV-2 infection. This thesis investigates the role of microtubule-associated End Binding Protein 3 (EB3) in …
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Therapeutic Application of Carbon Monoxide in Acute Limb Compartment Syndrome
… employing tissue culture of human vascular endothelial cells and serum of CS patients. CORM-3 was able to prevent free-radical formation, breakdown of endothelial barrier, apoptosis, leukocyte activation and transendothelial migration in response to CS stimulus. Thus, CORM-3 appears to have …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
… to loss of integrity in the alveolar epithelial-endothelial barrier. ARDS is associated with high mortality rates and there are currently no effective pharmacological therapies available. Human Mesenchymal Stromal Cells (hMSCs) are a promising candidate therapy which are currently being …
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Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… driven by vascular inflammation that begins with endothelial dysfunction. The endothelium, which lines blood vessels, plays a critical role in regulating vascular tone and immune cell interactions. In response to inflammatory stimuli, such as cytokines, endothelial cells become activated, …
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Sex dimorphism in the cardiometabolic effects of the smoothelin-like 1 protein deletion in an ageing mouse model
… smooth muscle contraction, myogenic response, endothelial barrier function, and inflammatory responses. Vascular function is known to reciprocally influence cardiac function, with impaired diastole and left ventricular (LV) stiffness causally linked to endothelial dysfunction and coronary …
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Systemic inflammatory regulation of blood-brain barrier inflammation
The endothelial cells of the blood-brain barrier are essential for the maintenance of homeostasis in the central nervous system. These cells act as a physical and transport barrier, restricting the movement of systemic immune cells and blood components into the brain. The physical barrier is …
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IDENTIFICATION AND CHARACTERIZATION OF THE 'GUT VASCULAR BARRIER'
… agents, the intestine has developed a number of barrier mechanisms to limit the entry of potential hazards. These include the physical barrier formed by the epithelial layer and the intestinal immune system that is important to induce either tolerance against food antigens and intestinal flora or …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
<p>The blood–brain barrier (BBB) is important in the normal function of the central nervous system (CNS). An altered BBB has been described in various neuropsychiatric disorders. The brain-specific microvascular endothelial cell (BMEC) is an essential structural component of the BBB. To test if …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
… to the pathology of ALI/ARDS by increasing endothelial barrier dysfunction. Many inflammatory mediators dictate the course and gravity of the response by inducing endothelial cytoskeletal reorganization, such as induction of actin stress fibers, cell rounding and contraction, and …
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