Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"endosomal transport"”.
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Regulation of Host Immune Responses by Toll-Interacting Protein During Citrobacter rodentium Infection
… and acts as a mediator of autophagy and endosomal transport. These mechanisms are involved in processes such cytokines expression, antigen presentation and mucus secretion. Although Tollip’s regulation of immune responses is well established, its role in A/E infections remains elusive. …
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Convective intracellular macromolecule delivery for cell engineering applications
… currents. Convective delivery is shown to bypass endosomal transport and is capable of achieving high intracellular delivery for a broad range of molecule types and sizes. Cell volume exchange is shown to be dependent on strain rate, magnitude of compression, and cell physical properties. The …
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Studien zum endosomalen Transport und der Signaltransduktion des Nervenwachstumsfaktors NGF unter physiologischen und pathophysiologischen Bedingungen
… within the cell. The neuro-trophic signal is transported in so called “signalling endosomes” which are retro-gradely transported over long distances from synapses to neuronal cell bodies. Sorting and transport defects severely impair the viability of neurons since the growth factors may need …
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Predicting angiogenic receptor trafficking and signaling via computational systems biology
… Furthermore, nuclear translocation requires late endosomal transport; blocking receptor trafficking from late endosomes to the nucleus reduces nuclear signaling 96%. These findings can be applied to understand specific RTK signaling functions in terms of cell response, and optimize RTK …
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Charakterisierung der Auswirkungen einer pathogenen Mutation im Neurotrophinrezeptorgen trkA im Zellkulturmodell
The development of the nervous system is a complex and highly regulated process in which the exact timing and location of the action of neurotrophins and their receptors plays an important role. They support survival and differentiation of neuronal cells. The prototypic neurotrophin NGF (nerve …