Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"endoproteolysis"”.
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Differenzielle Effekte von Presenilin-Mutationen auf die Generierung des Amyloid-ß-Peptids (Aß) und die Endoproteolyse des Notch-Rezeptors
… pathological Aß production was increased, endoproteolysis of Notch and nuclear transport of its cytoplasmic domain was significantly inhibited. These results demonstrate differential effects of PS proteins in the endoproteolysis of the ß-amyloid precursor protein and Notch.
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Role of Zmpste24 in Prelamin A Maturation.
… of the CAAX-box cysteine, there is a second endoproteolysis that occurs 15 amino acids upstream from the C-terminal farnesylated cysteine residue. Studies with knockout mice have implicated the enzyme Zmpste24 as a candidate to carry out one or both of these proteolytic reactions. In this …
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Metabolism of Alpha-Synuclein by the 20S Proteasome
… the formation of cytotoxic species by endoproteolysis of an intrinsically disordered protein. In that regard, a form of the 20S proteasome was identified that may be responsible for the endoproteolytic cleavage of intrinsically disordered proteins in vivo.