Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"endoplasmic reticulum stress"”.
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Altered Responses to Endoplasmic Reticulum Stress In Pancreatic Cancer
… has been made in understanding how proteotoxic stress affects rapidly proliferating pancreatic tumor cells. Endoplasmic reticulum (ER) stress occurs when protein homeostasis in the ER lumen is perturbed. ER stress activates the unfolded protein response (UPR) to reduce the protein load in the …
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Fic-Mediated AMPylation in Bacterial Infection and Endoplasmic Reticulum Stress
… unfolded protein response, is localized to the endoplasmic reticulum and is capable of AMPylating the ER chaperone BiP/GRP78. The progress made in these studies will contribute to understanding the role of this enigmatic modification in mammalian cell signaling.
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Role of Endoplasmic Reticulum Stress in Trophoblast Stem Cell Differentiation
… a mechanistic understanding of the effect of endoplasmic reticulum (ER) stress on the differentiation of trophoblast stem cells (TSCs), placental development, and subsequent pregnancy outcome. To address this question, I first used an in vitro mouse TSC model. Morphological observations …
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Role of SLMAP in Endoplasmic Reticulum Stress and Unfolded Protein Response
… by the molecular components of the sarco/endoplasmic reticulum (ER/SR). Disruptions in homeostatic balance of these proteins and calcium regulation results in activation of ER stress response. Sarcolemmal membrane-associated proteins (SLMAPs) are found in cell membrane, SR/ER, and …
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Molecular Adaptation of Pancreatic Beta-Cell Function During Endoplasmic Reticulum Stress
… to regulate protein concentrations in the endoplasmic reticulum (ER). During this process, reactive oxygen species (ROS) may originate as byproducts from the oxidative protein folding machinery in the ER, especially during an unfolded protein response (UPR). Using a beta-cell line (MIN6) …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… has also been implicated in the development of endoplasmic reticulum (ER) stress. We explored possible mechanisms by which acute metabolic changes in the hemodynamically stressed heart regulate mTOR activation, ER stress and cardiac function in the <em>ex vivo </em>isolated working rat heart. …
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Investigating the role of endoplasmic reticulum stress in neutrophils during tumour initiation
… revealed a list of upregulated genes linked to endoplasmic reticulum (ER) stress. I hypothesize a potential connection in mechanisms between ER stress and the trophic function of neutrophils associated with PNCs. In this project, I established an ER stress reporter zebrafish line …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… processes underlying this disease imperative. Endoplasmic reticulum (ER) stress has emerged as a potential mechanism driving the pathogenesis of obesity and T2DM. Palmitate, the predominant saturated fatty acid elevated in the blood plasma of obese individuals, induces ER stress and insulin …
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HIV Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress and Autophagy
… Recent studies indicate that activation of endoplasmic reticulum (ER) stress is an important cellular mechanism underlying HIV PI-induced dysregulation of lipid metabolism. However, the exact role of ER stress in HIV PI-associated lipodystrophy and dyslipidemia remains to be identified. …
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Characterization of The Role of Carma3 In Endoplasmic Reticulum Stress-Induced Nf-Κb Activation
<p>Endoplasmic reticulum (ER) stress-induced inflammation plays an important role in the progression of many diseases, such as type II diabetes, insulin resistance, cancers, and so on. NF-κB is believed to be a central regulator of ER stress-induced inflammation. However, studies on how ER stress …
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Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
… body of evidence points to a key role of endoplasmic reticulum (ER) stress in chronic and acute neurodegenerative diseases. Indeed, markers of ER stress are common features of neurons destined to die in these conditions. In the present study we demonstrate that PUMA, a BH3-only member of …
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Mechanisms Of Presynaptic CaV2 Calcium Channel Localization In Caenorhabditis Elegans
… transmembrane protein that resides in the endoplasmic reticulum, and is required for endoplasmic reticulum exit of UNC-2. Structure-function analysis revealed that the transmembrane domain and the cytosolic arginine-based basic motifs are important for the function of CALF-1. Acute …
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Arsenic trioxide in ovarian cancer
… dysfunction. This was accompanied by endoplasmic reticulum stress induction and an increase in intracellular glutathione (GSH) level. The latter was in turn prevented by the concurrent use of GSH modulator, buthionine sulfoximine but not ascorbic acid. Gene expression analysis of …
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Stress-inducible Mig6 promotes pancreatic beta cell destruction in the pathogenesis of diabetes
… demonstrated that diabetogenic assaults (e.g., endoplasmic reticulum stress, glucolipotoxicity, and pro-inflammatory cytokines) attenuate the activation of beta cell pro-survival signaling pathways via a stress-inducible molecule called Mitogen-inducible gene 6 (Mig6). We discovered that the …
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Bridging the gap between protein-tyrosine phosphorylation networks, metabolism and physiology in liver-specific PTP1b deletion mice
… amelioration of hepatic insulin resistance, endoplasmic reticulum stress, and whole-body lipid metabolism. However, the network alterations underlying these phenotypes are poorly understood. Mass spectrometry was used to quantitatively discover protein phosphotyrosine network changes in L-PTP …
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Role of ATG 5 in ER stress-induced apoptosis in meniscus.
… that saturated free fatty acid palmitate induces endoplasmic reticulum stress in primary porcine meniscus cells, and significantly decreased the protein level of ATG 5, a major autophagy related protein involved in autophagosome formation. Downregulation of ATG 5 protein levels was associated with …
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TEMPOL and Insulin Resistance: A study of the underlying mechanisms behind changes in glucose metabolism, lipid accumulation and cellular stress
… Overnutrition-induced obesity drives oxidative stress and inflammation, leading to insulin resistance. There are currently no successful treatments to treat insulin resistance or its downstream clinical sequelae. It was hypothesized that TEMPOL, a nitroxide, could suppress diet-induced insulin …
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Investigating the metabolic impact of Metformin and Berberine in combination with Venetoclax for Acute Myeloid Leukaemia treatment
… COX5A, decreased NDUFA4). Additionally, endoplasmic reticulum proteins related to protein folding and ubiquitylation were upregulated, suggesting endoplasmic reticulum stress. These findings suggest that the Met+Ven combination could induce both ER and mitochondrial stress, leading to …
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