Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"endometrial stromal cells"”.
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Progesterone Enhances Macrophage Colony-Stimulating Factor(M-CSF) Production in Human Endometrial Stromal Cells in vitro
本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである
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The Possible Role for Basigin Receptor Function in The Induction of Matrix Metalloproteinase Expression in Human Endometrial Stromal Cells
… shown to induce MMP expression in vitro in human endometrial stromal cell lines (HESC). Understanding how basigin induces matrix metalloproteinases within normal cellular conditions will help researchers understand how these signaling cascades flow in the framework of implantation. In order to do …
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Role of Extracellular Signal-Regulated Kinase and Peroxisome Proliferator-Activated Receptor gamma on Transforming Growth Factor-β1-Induced Human Endometrial Stromal Cell Decidualization
… of ERK and PPAR gamma on TGF-β1-induced human endometrial stromal cell decidualization in vitro. MATERIALS AND METHODS: Human endometrial tissues obtained by hysterectomy specimens from patients with conditions other than endometrial diseases such as leiomyoma. Endometrial stromal cells were …
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Identification of molecular signaling pathways underlying human endometrial stromal cell differentiation
Decidualization, the differentiation of endometrial stromal cells, is essential for a successful pregnancy. Although the steroid hormones estrogen (E) and progesterone (P) are known to control decidualization, the precise mechanisms via which these hormones act to control this differentiation …
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Progesterone control of human endometrial cells
… In humans these changes are most dramatic in the stromal compartment and are influenced by progesterone, secreted by the Corpus Luteum (CL). This hormone is believed to be the main factor inducing such differentiation in the oestradiol-primed stroma. However, mediators with the ability to activate …
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ROLES OF HAND2 TRANSCRIPTION FACTOR IN UTERINE RECEPTIVITY AND DECIDUALIZATION
… the mother endometrium. At the same time, the endometrial tissue undergoes the process of decidualization to support the anchoring of the blastocyst and provides the blastocyst with nutrition until the fully functional placenta is formed. Although the process of implantation and decidualization …
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Role of transcription factor Runx1 in uterine stromal cell differentiation and maternal-fetal interaction during mouse pregnancy
The differentiation of endometrial stromal cells to decidual cells, a process known as decidualization, is essential for the establishment of pregnancy. The decidual tissue produces multitude of factors that control a variety of physiological processes at the fetal-maternal interface, such as …
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Progesterone receptor targets play critical roles in maintaining pregnancy and disease prevention
… and silenced in uteri from women diagnosed with endometrial hyperplasia and cancer. The study presented in chapter 2 demonstrates that exposure to the environmental toxicant bisphenol-A (BPA) causes increased methylation at the Hand2 promoter and reduced HAND2 expression. BPA also stimulated …
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Mechanisms underlying establishment and maintenance of pregnancy
… 2 alpha (Hif2α), which is induced in subluminal stromal cells at the time of implantation, plays a crucial role during early pregnancy. Indeed, when preimplantation endometrial stromal cells are exposed to hypoxic conditions in vitro, we observed a striking enhancement in HIF2α expression. …
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The impact of advanced maternal age on endometrial differentiation and placental development
… obvious in the peri-implantation window, with endometrial stromal cells from aged females being unable to mount an adequate decidualization response due to a decline in their ability to respond to pregnancy hormones. This blunted decidualization reaction in turn may lead to abnormal development …
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Estrogen signaling during decidualization
… by the deciduous transformation of fibroblast endometrial stromal cells to morphologically and functionally unique decidual cells along with the formation of extensive neo-angiogenic networks that play pivotal role in nourishing the developing embryo. Steroid hormones estrogen (E) and …
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Role of Chlamydia trachomatis infection in adverse pregnancy outcomes
… unknown. A successful pregnancy requires normal endometrial stromal cell (ESC) decidualisation and trophoblast invasion, processes that involve chemokine action and lead to successful implantation. My objectives were to determine whether Ct infection impacts upon ESC decidualisation and chemokine …
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Expression and function of basigin during early pregnancy and spermatogenesis
… for the interactions between gametes and Sertoli cells during spermatogenesis. BSG protein was expressed in the uterine epithelium at estrus in βERKO mice but not in αERKO mice. However, a higher level of Bsg mRNA was observed in the uteri of αERKO mice as compared with wild type (WT) and βERKO …
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Determining the endometrial phenotype of women with abnormal uterine bleeding
… the myometrium, yet, the mechanism by which the endometrial phenotype might be modified, with consequent AUB, is unknown. Research to-date has predominantly investigated the cellular and molecular changes occurring within the fibroid or adenomyotic lesion, however, there is lack of evidence …