Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"endomembrane"”.
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Illuminating Organellar and Molecular Organization of the Endomembrane System
The endomembrane system consists of virtually all of the structurally and functionally distinct membrane compartments in a eukaryotic cell, except mitochondria and plastids. Different compartments in the endomembrane system communicate with each other through vesicular transport as well as direct …
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Investigating the function of the hereditary spastic paraplegia protein spastin in the endomembrane system
Hereditary spastic paraplegias (HSPs) are genetically inherited neurological diseases characterised by the distal axonal degeneration of corticospinal neurons. Of the 80 genes currently associated with HSP, mutations in SPAST, encoding the protein spastin, are by far the most common cause of …
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RNA Localization and Translational Regulation on the Endoplasmic Reticulum
… and translational regulation of mRNAs encoding endomembrane transmembrane proteins. HITS-CLIP and PAR-CLIP analyses of the AEG-1 mRNA interactome of human hepatocellular carcinoma cells revealed a high enrichment for mRNAs encoding endomembrane organelle proteins, most notably encoding …
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Autophagy in the developing Drosophila brain
… of the larval Drosophila brain. The role of the endomembrane system in autophagy in neurons and neural stem cells was also considered, as was the movement of acid-resistant protein from neural stem cell lineage to the surrounding cortex glia. The location of various proteins involved in nutrient …
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The Role of ERp57 in Hras Intracellular Trafficking and Function.
… by vectorial vesicular transport from the endomembrane system. ERp57, an ER chaperone, has been shown to specifically bind farnesylated Hras but not non-farnesylated Hras. The objective of this study was to determine if ERp57 participates in Ras trafficking and function. First, the effect …
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The Role of the SCD1 Protein in Targeting PIN2 Protein in Arabidopsis Thaliana
… altered localization and accumulation in endomembrane bodies. The endomembranes that accumulated PIN2
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Lost in Translation: Variations in WNT Signaling and Other Translational Changes in a Drosophila Model of ALS
… suggests that Dlp puncta represent defunct endomembrane compartments and that TDP-43-Dlp dynamics persist outside of motor neurons.
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Assessment of endosomes as sites of signal transduction in plants during bacterial attack
Endomembranes are integral to cellular function and particularly to plant defence. Environmental signals are perceived and immediate signalling responses are triggered from the PM, but how information is effectively transduced to generate the appropriate responses is less well understood. …
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Novel detection and evasion mechanisms pertinent to immunity against Salmonella Typhimurium
… pathogens enter the cytosol they can damage host endomembranes, causing the mislocalisation of host molecules not normally found in the cytosol that are sensed as Danger Associated Molecular Patterns (DAMPs). Glycans exposed on damaged endomembranes are detected by danger receptors such as …
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Structural characterisation of V-ATPases by electron microscopy
… pump protons into the interior of most cellular endomembrane compartments at the expense of ATP. V-ATPases are comprised of a membrane-integrated proton-translocating part (V0) and a soluble catalytic part (V1). There are indications for multiple stalks connecting V1 and V0, however up to now …
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Regulatory domains of the Arf GEF Sec7 scaffold autoinhibited and active conformations
… Network (TGN), connects the Golgi to the endomembrane system and balances the flow of membranes and cargo throughout the cell. Virtually all sorting and transport at the TGN is dependent on the small GTPase Arf1 which drives vesicle formation and membrane modification following its …
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Dynamics and Fate of the inner Membrane Complex in Apicomplexan Parasites
… highlighting the stripped-down apicomplexan endomembrane system, and providing a map of SNAREs likely to be involved in distinctive parasite function(s).
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Investigation Of The Interconnected Roles Of Cmal And Hopaa1-1 In The Virulence Of Pseudomonas Syringae Pv.Tomato Dc3000 In Nicotiana Benthamiana
… suggesting that HopAA1 -1 interacts with the endomembrane system. A DC3000 mutant with 28 T3E genes deleted (DC3000D28E) is a recently developed tool for investigating effector functions. DC3000D28E derivatives with small sets of effector genes progressively restored show increasing virulence …
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Structural and biophysical characterization of membrane-coating proteins from the nuclear pore and the primary cilium
A hallmark of eukaryotes is an endomembrane system that spatially separates cellular processes into discrete compartments. Macromolecular transport between these compartments canonically involves the fission and fusion of membrane-bound vesicles. Transport to and from the nucleus is a notable …
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A New Approach To Identifying Effectors and Regulators of Small GTPases
… executed and tightly regulated by the cell’s endomembrane system. It is widely accepted that small GTPases of the Ras superfamily are major regulators of membrane trafficking and signalling, ensuring specificity and efficiency through their spatiotemporal regulation.Identifying the proteins …
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Mass Spectrometric Analysis of Tyrosine Metabolic Enzymes
… and trafficking of secreted proteins in the endomembrane system. The analysis of glycosylation sites in DCE and DCT therefore is essential toward achieving a comprehensive understanding of their structure and function. Like DCT, AMD also plays a protective role. The AMD protein was originally …
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Structural Characterisation of the Mammalian SRP Receptor
… complexes at or targeting of vesicles to the endomembrane system. Important structural information on the mammalian SRP:SR complex are still missing, including the arrangement of the individual protein subunits and the positioning of the SRP RNA. Extensive purification and assembly of a …
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Biophysical and structural characterization of components from the nuclear pore complex and the ubiquitin pathway
Formation of an endomembrane system in the eukaryotic cell is a hallmark of biological evolution. One such system is the nuclear envelope (NE), composed of an inner and outer membrane, used to form a nucleus and enclose the cell's genome. Access to the nucleus from the cytoplasm is mediated by a …
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The role of Atgolgin-84A at the plant ER-Golgi interface
The eukaryotic cell is compartmentalised into an endomembrane system organised into several organelles. Some of these organelles, namely endoplasmic reticulum (ER) and Golgi bodies, are part of a so-called secretory pathway where vital cell components travel to reach the correct final destination …
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Structural and biochemical analysis of the Y-shaped Nup84 subcomplex of the NPC
… counterpart through the presence of a complex endomembrane system. Most notable is the nucleus, which harbors and protects the genetic information of the cell. Such physical separation allows for extra layers of regulation for a variety of cellular processes, but at the same time, necessitates …
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