Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"endolysins"”.
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Bacteriophage Endolysins: Anti-Infectives and Lysidiagnostics for the Post-Antibiotic ERA
… such novel approach, the use of bacteriophage endolysins as diagnostic (lysidiagnostics) and therapeutic (enzybiotics) tools for pathogens of human disease. Endolysins are modular proteins that facilitate release of progeny phage by digesting the bacterial host cell wall. Structurally, …
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Characterization of US Queso Fresco and endolysins for Queso Fresco implementation
… of addressing post processing contamination. Endolysins are a class of cell wall hydrolases derived from bacteriophages, which have been shown to be promising candidates for controlling pathogens in food systems. Endolysins derived from gram positive bacteriophages are incredibly diverse. …
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The isolation and assessment of the antimicrobial activity of bacteriolytic and bactericidal endolysins of enterobacteriaceae infecting bacteriophages
Thesis submitted in fulfilment for the requirements of the degree of Master of Health Science in Medical Laboratory Science, Durban University of Technology, Durban, South Africa, 2025.
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Functionalization of phage endolysins to treat infections of spore-forming Clostridia bacteria in the era of antibiotic resistance
Certain *Clostridia* species are notable pathogens, not only because they form highly resistant endospores but because they produce toxins and exhibit antibiotic resistance. *Clostridioides difficile* is a nosocomial pathogen responsible for thousands of deaths every year, whereas *Clostridium …
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Production and characterization of a phage endolysin with putative antimicrobial activity against Cutibacterium acnes
… to be developed to treat acne. One option is endolysins, highly conserved enzymes from bacteriophages that disrupt the bacterial cell wall. Endolysins retain bactericidal and bacteriostatic activity when applied to bacteria in vitro and are safe for topical application. We hypothesize that the …
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Lysin Based Antimicrobial Peptides Against Acinetobacter Baumannii
… alternative therapies, including bacteriophage endolysins with potent antibacterial activities. A common feature of these lysins is the presence of a highly positively charged C-terminal domain with a likely role in promoting outer membrane penetration. In the current study, we show that the …
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In vitro model development for novel prevention measures against foodborne pathogens
… means of killing L. monocytogenes, bacteriophage endolysins were identified to have considerable potential for overcoming limitations of other antimicrobials in foods such as fresh cheeses. Endolysins are peptidoglycan hydrolases that lyse bacteria as part of the bacteriophage lytic cycle. They do …
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Understanding and exploiting bacteriophage-host interactions for the control and detection of listeria monocytogenes
… from grass silage and characterized. The endolysins and putative receptor binding proteins were identified in the genomes of these phages, and these proteins may be exploited in future applications for the biocontrol and detection of L. monocytogenes. In this thesis, new phages have been …
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Controlling bacterial contaminants in sugarcane ethanol fermentations
… such as bacteriophages, or engineered phage endolysins and bacteriocins.
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Alternative treatments for bovine and human mastitis
… on probiotics, bacteriocins, phages, and phage endolysins. Chapter 2 examines the microbiology and treatment of human mastitis with Staphylococcus aureus, Staphylococcus epidermidis, and Corynebacterium sp. being identified as the major etiological agents in acute, subacute, and granulomatous …
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Bacteriophages in the honey bee gut and amphibian skin microbiomes: investigating the interactions between phages and their bacterial hosts
… and testing, its high homology to chitinase and endolysins suggest it may be involved in the breakdown of either fungal or bacterial cellular wall components. Finally, my fourth chapter revisits the honey bee gut system by investigating the role of geographic distance in bacteriophage community …
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Expanding the Horizons of Enzybiotic Identification
<p>Recently, phage lytic enzymes (also known as endolysins or, simply, lysins) have received considerable attention as potential antibacterial agents. During the infective cycle of double-stranded DNA phage, these peptidoglycan hydrolases are responsible for digesting the cell wall of the host …
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Mode of Action of Penicillin in Pneumococci: From Inhibition of Cellular Targets to Bacterial Death
… membrane-active "channel" proteins (holins) and endolysins in bacteriophage induced lysis of bacteria. </p>