Global ETD Search
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Showing 1 to 20 of 34 for “"endogenous retroviruses"”.
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Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
… the host. Those inherited proviruses are termed endogenous retroviruses (ERVs) and have been identified in a variety of animal species representing an extensive viral "fossil" record of past retroviral infections. With the advent of whole genome sequencing projects and high throughput sequencing …
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Insertionally polymorphic human endogenous retroviruses and their potential role in cancer
In this study a family of endogenous retroviruses, HERV-K(HML-2) was investigated. The family is the youngest endogenous retrovirus family known in humans, with some of its members being insertionally polymorphic in modern human populations. There have been numerous reports of HERV-K(HML-2) members …
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Identification and characterisation of murine metastable epialleles conferred by endogenous retroviruses
… The best known example is the Avy locus where an endogenous retrovirus (ERV) of the intracisternal A-particle (IAP) class was spontaneously inserted upstream of the agouti coat colour gene, resulting in variable IAP promoter DNA methylation, variable expressivity of coat phenotype, and …
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Variable methylation of endogenous retroviruses: epigenetic inheritance, environmental modulation, and genetic modifiers
… (IAPs) are evolutionarily young murine-specific endogenous retroviruses (ERVs). Some are capable of retrotransposition and many harbour regulatory sequences with the potential to influence host gene expression. Previous work has shown that, at the Agouti Viable Yellow (Avy) locus, an IAP …
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Investigation of Endogenous Retroviruses in the Pathogenesis of Sporadic Amyotrophic Lateral Sclerosis (ALS) by
Human Endogenous Retroviruses (HERVs) are remnants of ancient retroviral infections that have become incorporated into the human genome over the course of our evolution as a species. These fossil viruses have been co-opted by our genome as regulators of cellular gene expression amongst various …
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The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
Human endogenous retroviruses (HERVs) are estimated to form approximately 5% of the human genome. While the majority of sequences are defective, containing premature stop mutations and frameshift mutations, a number encode fully functional proteins. HERVs have been proposed as aetiological agents …
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Functional Analysis of Daxx In Tumorigenesis of Pancreatic Neuroendocrine Tumors and Embryonic Development
… however, does cause dysregulated expression endogenous retroviruses. On the contrary, the interaction between Daxx and H3.3 is not required for embryonic development but is essential for postnatal viability. Transcriptome analysis of embryonic tissues demonstrates that this interaction is …
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New Targets of p53 Regulation: From Aging to Immune Response
… and p53 -/- cells. Mmergln-int is a murine endogenous retrovirus that is transcriptionally upregulated in response to cellular stress and regulated by a highly conserved p53 response element in the LTR. When overexpressed, the envelope of Mmergln-int is sufficient to decrease cell viability. …
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Retroviruses in the common brush-tailed possum (Trichosurus vulpecula)
… details the search for, and characterisation of, retroviruses in a marsupial, the common brush-tailed possum (Trichosurus vulpecula). Initial efforts were directed at detecting exogenous retroviruses in possums, but the majority of the work described in this thesis involved the isolation and …
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Avian leukosis virus as a risk factor for ovarian adenocarcinoma in layer hens
… epidemiological characteristics. Recently, human endogenous retroviruses (HERVs) have been shown to be associated with ovarian cancer in women. Hens also have endogenous retroviruses, notably Avian Leukosis Virus E (ALV-E). The link between ALV-E and OAC in hens has not been adequately …
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Mechanisms of toxicity in cell models of FSHD
… that are enriched for Alu and LINE-1 elements, endogenous retroviruses, as well as from pericentric sequences enriched forhuman satellite II (HSATII) repeats. Similar to pericentromeric repeat expression in the early mouse embryo, bidirectional HSATII transcription appeared to be temporally …
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Characterization of The Role(S) of Env Protein of Human Endogenous Retrovirus-K In Multiple Human Cancers
<p>Human endogenous retroviruses (HERVs) are remnants from ancient retroviral infections, and most of them are inactive in normal tissues. One family of HERV, HERV-K, is found to be associated with multiple human cancers including breast cancer, pancreatic cancer and melanoma, but the causal …
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The Detection and Role of Human Endogenous Retrovirus K (HML-2) In Rheumatoid Arthritis
Human endogenous retroviruses are the remnants of ancient retroviral infections present within our genome. These molecular fossils show similarities with present day exogenous retroviruses but act as typical Mendelian elements that are passed vertically between generations. Despite being repeatedly …
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The Impact of Host Factors on Retroviral Evolution and the Identification of a Novel Receptor That Was Used by an Ancient Primate Retrovirus
<p>The resurrection of inactive endogenous retroviruses allows us to learn about interactions between extinct pathogens and their hosts that occurred millions of years ago. Two of these paleoviruses, chimpanzee endogenous retrovirus 1 and 2 (CERV1 and CERV2), are relatives of modern murine leukemia …
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INTERACTIONS BETWEEN THE GLYCOSYLATED GAG PROTEIN OF A MURINE LEUKEMIA VIRUS AND MURINE APOBEC3: NOVEL INSIGHTS INTO HOW A MURINE LEUKEMIA VIRUS COUNTERACTS A RESTRICTION FACTOR
… with very little affect on in vitro replication. Endogenous retroviruses have not been found to express gGag and are tightly controlled by mA3. APOBEC3 proteins are expressed in many tissues in the mouse but are not expressed in most in vitro cell lines. These observations are consistent with a …
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INTERACTIONS BETWEEN THE GLYCOSYLATED GAG PROTEIN OF A MURINE LEUKEMIA VIRUS AND MURINE APOBEC3: NOVEL INSIGHTS INTO HOW A MURINE LEUKEMIA VIRUS COUNTERACTS A RESTRICTION FACTOR
… with very little affect on in vitro replication. Endogenous retroviruses have not been found to express gGag and are tightly controlled by mA3. APOBEC3 proteins are expressed in many tissues in the mouse but are not expressed in most in vitro cell lines. These observations are consistent with a …
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Characterization of Human Endogenous Retrovirus sequences identifed in the human genome using the RetroTector software
Human Endogenous Retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the proviral integrated elements to the descendants. Actually, no replication-competent HERV sequence is recognizable in the human …
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The Contribution of Retrotransposons to the Transcriptomes of Murine Somatic Cells
… clusters based on retrotransposon sequence, with endogenous retroviruses being particularly prevalent in retrotransposon-rich transcripts. While these clusters are consistent between cell types, the individual retrotransposons transcribed show cell-type specificity. I also find evidence that …
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Latency, Expression and Splicing During Infection With HIV
… cellular genes and abundance of RNA from human endogenous retroviruses. We also quantified the frequency and location of chimeric HIV-host RNAs. These two studies together provided a detailed accounting of both HIV89.6 and host expression and alternative splicing. A more cost-effective method of …
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Bioinformatics analyses of non-coding genomic elements
… three types of non-coding sequences: endogenous retroviruses, microsatellite markers and transcription factor binding sites. I conducted the bioinformatics design, coding and analyses, working with collaborators who verified findings in the laboratory. The only retrovirus known to be …
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