Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"endogenous ligands"”.
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Characterisation of the Apelin Receptor and its Endogenous Ligands, Apelin and Elabela/Toddler in the Cardio-Renal System
… the apelin receptor, which binds two peptide ligands, namely apelin and Elabela/Toddler (ELA). Although apelin has been studied in some detail, little is known about the expression and function of ELA, and the renal apelin system. The aim of this study was to characterise the expression of ELA …
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The role of CCR7 axis in facilitating chemoresistance, radioresistance and induction of cell proliferation in cancer
… Chemokine receptor CCR7, activated by its ligands CCL19 & CCL21, is known to play a significant role in cancer metastasis. In view of the wider roles that chemokines play in the biology of the cell, we hypothesised that CCR7 could influence cancer progression through other mechanisms in …
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Pathological mechanisms of the ischemic white matter injury in animal model of lacunar infarction
… area. To modulate or activate TLR2 on OLs, endogenous ligands of TLR2 must be present and bind to the cognate receptor. Several endogenous ligands from intracellular contentssuch as heat shock protein family or high mobility group box 1 (HMGB1).have been identified. I found substantial …
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Immunological Impact of CLI-095 on Dendritic Cell Maturation and Hypoxia-re-oxygenation induced inflammatory injury
… the engagement of Toll-Like Receptors (TLRs) by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation. Stimulation of TLR4 induces distinct patterns of gene expression, which not only leads to the activation of innate immunity but also …
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Functional Significance of Glycoprotein Clearance by the Asialoglycoprotein Receptor and the Mannose/GalNAc-4-SO4 Receptor
… I am taking a genetic approach identifying endogenous ligands for the ASGR and the MR in vivo and establishing the biologic significance of clearing these glycoproteins from the blood. A number of glycosylated hormones such as luteinizing hormone: LH), thyroid stimulating hormone, and the …
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Cluster Determinant 44 (CD44) Receptor and Gout: Mechanistic Role in Pathogenesis and Therapeutic Targets
… essential role in inflammation. The binding of endogenous ligands to CD44 on the surface of macrophages was shown to result in ligand internalization. In this project, we aimed to assess the role of CD44 using in vitro models of BMDMs of different genotypes and used Extra cellular domain …
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Toll-like receptor mediated responses to adsorbed damage-associated molecular patterns on biomaterial surfaces
… has been studied extensively, the presence of endogenous, matrix- and cell-derived mediators of inflammation within the adsorbed protein layer and their impact on cell-material interactions is not well understood. Damage-associated molecular patterns (DAMPs) are endogenous ligands released by …
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Life Without GPR7, the Neuropeptide W1 Receptor: Regulation of Energy Homeostasis by GPR7 and its Endogenous Neuropeptide Ligands
… induced obese mice. In this screen, GPR7, the endogenous G protein-coupled receptor (GPCR) for the recently identified ligands neuropeptide B (NPB) and neuropeptide W (NPW), was found to be specifically down-regulated after GTG treatment. The physiological role of GPR7 was investigated by …
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Complement in Disease - Extracellular Proteins as Complement Regulators
… together, several novel interactions between endogenous ligands and complement have been found, which might regulate the progression of different disease processes.
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THE ROLE OF EPIGENETICS IN TRANSCRIPTIONAL REGULATION OF FXR AND SILENCING FXR EXPRESSION IN HUMAN COLON CANCER
… receptor superfamily and bile acids are its endogenous ligands. FXR is a critical regulator of the enterohepatic circulation of bile acids, lipid homeostasis, glucose metabolism, and tumor suppression in liver and intestine. Consequently, FXR has become a very promising therapeutic target for …
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Studies on the optimization of expression and purification & Functional characterization of Class C – GPCRs
… the signal is transduced by diverse activating endogenous ligands binding on the extracellular surface. This results in the uncoupling of G-proteins from the cytoplasmic loops, leading to the activation of the second messengers. GPCRs have enormous therapeutic importance due to their involvement …
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Structural basis for the function of the transcriptional regulator KstR from Mycobacterium tuberculosis
… The interactions between KstR and cognate DNA or ligands have been investigated by multiple biochemical techniques (i.e. electrophoretic mobility shift assay, surface plasmon resonance and intrinsic fluorescence quenching assay). Protein-DNA binding assays have demonstrated that the 21-amino-acid …
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Ligand-induced selective signalling at the gonadotrophin releasing hormone receptor
… with Gq/11 activation. We propose that the two endogenous ligands, GnRH I and GnRH II, and certain antagonists selectively activate distinct signalling pathways by stabilisation of distinct active conformations of the GnRH receptor, a concept termed ligand-induced selective signalling (LiSS). …
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Development and application of methods for analysis of fungal glycosphingolipid structure and functional interactions
… phosphorylceramides (GIPCs) could be endogenous ligands of such fungal lectins, structural characterization of glycosphingolipids (GSLs) from the fruiting bodies of these mushrooms was performed. The extraction, isolation and purification of the lipids, and their subsequent …
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Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
… which is comprised of cannabinoid receptors and endogenous ligands, have rapidly expanded in recent years. The endocannabinoid system can modulate the activity of other neurotransmitters through the type 1 cannabinoid receptor (CB1R) which is highly expressed in the human brain1,2. Defects in …
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Antiplatelet and antihypertensive actions of ridogrel
… for thromboxane (TP) responds to multiple endogenous ligands. Inhibiting the synthesis of thromboxane does not prevent functional responses mediated by TP receptors. Ridogrel is an investigational drug with dual activities as an antagonist of TP receptors, and an inhibitor of thromboxane …
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Targeting Transcription Factors in Neuroblastoma: Development of Aurora Kinase A/N-Myc Degraders and ID2 Chemical Probes
… molecules is challenging as they frequently lack endogenous ligands or amenable ligandbinding sites. The thesis will discuss our efforts in the development of novel chemical modulators of TFs in neuroblastoma using targeted protein degradation. N-Myc overexpression is the most frequent driver in …
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Physical fitness and exercise as modulators of the endocannabinoid system in adults with mild-to-moderate depression the sonrie study
… The primary and most well studied endogenous ligands are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These components, along with associated analogues interact with CB1 and CB2 receptors. CB1 receptors are abundant in the central nervous system and implicated in cognitive, …
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Endocannabinoid regulation of gastric vagal afferent signalling
… via cannabinoid 1 (CB1) receptors and are also endogenous ligands for TRPV1. The CB1 receptor and TRPV1 are expressed on GVAs and the CB1 receptor is also expressed on gastric ghrelin cells. Further, the endocannabinoid anandamide (AEA; ligand for CB1) is expressed in the stomach. However, it is …
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The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function
… synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. The total number of GPCRs is estimated to be around 800 where approximately 160 still are "orphans", meaning that the endogenous ligands are …
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