Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"endogenous cannabinoid"”.
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ENDOGENOUS CANNABINOID SYSTEM MODULATION OF THE REINFORCING PROPERTIES OF ETHANOL DURING DEPENDENCE: IMPLICATIONS FOR ALCOHOL USE DISORDERS
Alcohol use disorders (AUDs) are a significant source of health and economic cost to society within the United States. Despite this, highly efficacious treatments for AUDs remain elusive. An AUD is a chronically relapsing disorder characterized by a cycle of preoccupation/wanting of ethanol, …
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Central cannabinoid regulation of food intake in chickens
… of the antimarijuana attitude, research with cannabinoids was neglected for a long time. Although this substance is related to social problems, scientists are interested in its action and possible medicinal properties. Since the identification of the structure of Î 9--tetrahydrocannabinol, the …
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Endocannabinoid Modulation of Spatial Memory in Aversively and Appetitively Motivated Barnes Maze Tasks
… procedures. Conversely, enhancing endocannabinoid signaling, via genetic deletion of the FAAH enzyme, accelerated acquisition of the task under aversive, but not appetitive, conditioning procedures. Accordingly, these data strongly support the hypothesis that the endogenous cannabinoid …
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The Effects of Δ9-tetrahydrocannabinol (THC) on development and hyperekplexia in embryonic zebrafish model
… disorders. Though there are over 100 different cannabinoids produced by the cannabis plant, Δ<sup>9</sup> – tetrahydrocannabinol (THC) has been shown to the most efficacious phytocannabinoid in neurological disorders. THC has been shown in numerous previous studies to be effective at treating …
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Effect of cannabinoids on pain-stimulated and pain-depressed behavior in rats
Cannabinoids produce antinociception in many preclinical models of acute and chronic pain. In contrast, cannabinoids produce inconsistent analgesia in humans, showing little or no efficacy in treating acute pain, with modest efficacy in treating chronic inflammatory pain. This discrepancy may …
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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice
… hundreds when Cannabis components known as phytocannabinoids were characterized and later isolated. In the 1970’s, ∆9-tetrahydrocannabinol (THC) was isolated and recognized as the major constituent responsible for the psychoactive and intoxicating effects associated with consumption of cannabis. …
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From macromolecular crowding to transcriptional regulation: Exploring the complexities of cytochrome P450s, cannabinoids, and inflammation
… and have been shown to interact with the endogenous cannabinoid system. The determination that eicosanoids also function as endocannabinoids has opened the door to comparisons with phytocannabinoids and questions about how the presence This work is aimed at untangling the complex web of …
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The role of the periaqueductal gray in modulation of acute and chronic pain: Actions of drugs with analgesic properties on periaqueductal gray neuronal network
… patients receiving chemotherapeutic regimen. Endocannabinoids, such as anandamide (AEA), are lipid neuromodulators in the CNS that affect nociception. AEA is known to activate cannabinoid (CB1) as well as transient receptor potential vanilloid 1 (TRPV1) receptors, which are involved in …
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Targeting the Endocannabinoid System to Reduce Inflammatory Pain
<p>The endogenous cannabinoids (endocannabinoids) anandamide (AEA) and 2-arachidonylglycerol (2-AG) exert their effects predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol …