Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"endocrine treatment"”.
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Identification of therapeutic targets to revert tamoxifen resistance by quantitative proteomic analysis of signaling networks
Tamoxifen resistance is the biggest problem in endocrine treatment against hormone receptor positive breast cancer patients. HER2 is a membrane receptor tyrosine kinase that is known to correlate with poor disease outcome and unresponsiveness to endocrine treatment. Although much work has been done …
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Phosphorylation of ERα and HIF-1α in breast cancer with focus on tamoxifen response and links to kinase activation
… are commonly used in adjuvant breast cancer treatment and for a long time tamoxifen has been the main endocrine treatment. Patients who are eligibly for endocrine treatment are selected by the tumour-specific expression of oestrogen receptor (ER) and approximately 70 % of all breast cancer …
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Localized and disease-selective drug delivery using adhesive hydrogels for treatment of locally advanced TNBC
… HER2, and hence it is not treatable with common endocrine treatment such as tamoxifen or Herceptin. Systemic neoadjuvant therapy has been established as the preferred therapeutic approach for locally advanced breast cancer, downstaging the disease and preventing mastectomy. However, complications …
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Discovery and validation of novel blood biomarkers of breast and prostate cancer
… B1 in patients undergoing chemotherapy and endocrine treatment correlated with complete response to treatment. Additionally, the utility of BORIS as a diagnostic marker was investigated in plasma of breast cancer patients and urinary sediments and exosomes of prostate cancer patients. The …
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Prognostic and Treatment Predictive Markers Associated with Cyclin D1 Gene Amplification and Epithelial-Mesenchymal Transition in Breast Cancer
Endocrine resistant breast cancer is a major therapeutical challenge and accurate selection of patients susceptible to certain types of anti-hormonal treatment strategies is pivotal. Discovery of novel biomarkers potentially predicting treatment response as well as the clinical course of breast …
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Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
… CCN5 is not restricted to the normal cells. CCN5 treatment leads to an expression of functional ER-α in the TNBC cells, both in-vitro and in xenograft models, and sensitizes these cells to tamoxifen, commonly used for endocrine therapies. Mechanistically, transcriptional activation of ER-α by CCN5 …
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Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancer
… is the most widely and successfully used endocrine treatment for pre-menopausal women with ERα positive breast cancer. However, subgroups of patients are resistant to this drug. Investigation into the mechanisms of the endocrine refractory phenotype would therefore open possibilities for …
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Proteomic Investigation of Endocrine Therapy Resistance in Breast Cancer Investigating the Molecular Mechanisms for SERM Resistant Cell Lines Using SILAC-Based Proteomic Approach
… thereby limiting the success in breast cancer treatment. In this study, mechanisms of resistance were investigated using a novel multi-stable isotope labelled amino acids (SILAC) proteomics approach in phenotype-specific breast cancer cell lines resistant to endocrine treatment. Method: In …
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Cellular and molecular mechanisms of response to, and recurrence following, breast radiotherapy
… tumour recurrences following breast conserving treatment have long been noted to predominantly occur in or close to the tumour bed from which the index cancer was removed with a smaller number arising in other quadrants of the breast. A widely held hypothesis is that breast cancer local …
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Predicting Prognosis and Tamoxifen Response in Breast Cancer. With a special focus on contralateral breast cancer.
One of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of …