Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"endocrine resistance"”.
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The role of metabolic rewiring in endocrine resistance
… occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to prevent or delay recurrence of ERα (+) tumors. The overall objective of this dissertation project is to define the interaction among endocrine resistance, nuclear export …
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Novel insights into the molecular mechanisms of endocrine resistance in ERα positive breast cancer
… is the most widely and successfully used endocrine treatment for pre-menopausal women with ERα positive breast cancer. However, subgroups of patients are resistant to this drug. Investigation into the mechanisms of the endocrine refractory phenotype would therefore open possibilities for …
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Regulation of estrogen receptor-alpha mediated gene expression and endocrine resistance through estrogen receptor-alpha phosphorylation and micro-RNA in breast cancer
… of human breast cancer and the development of resistance to endocrine therapies are thought to be associated with ER phosphorylation. We generated multiple combinations of ER phospho-mutants, at residues serine 104, 106, 118, 167, 236, and 305, and examined their impact on receptor half-life, …
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The Role of Androgen Receptor Signalling in Endocrine Resistant Breast Cancer
… among women in the UK. The majority of BCas are endocrine sensitive and develop through the action of oestrogens, facilitated through the transcription factor Oestrogen Receptor alpha (ERα). Treatment for these patients usually involves endocrine therapies (Aromatase Inhibitors and …
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Mechanism of tamoxifen resistance in breast cancer
<p>Acquired tamoxifen resistance develops in the majority of hormone responsive breast cancers and frequently involves overexpression of the PI3K/AKT axis. Here, breast cancer cells, with elevated endogenous AKT or overexpression of activated AKT exhibited tamoxifen-stimulated cell proliferation …
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Systems Biology Study of Breast Cancer Endocrine Response and Resistance
… cells can hijack this plasticity to develop drug resistance. For example, breast cancers that are initially responsive to endocrine therapy often develop resistance robustly. This process is dynamically controlled by interactions of genes, proteins, RNAs and environmental factors at multiple …
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Novel Monte Carlo Approaches to Identify Aberrant Pathways in Cancer
… (ER) signaling pathways are related to drug resistance. The identified pathway proteins from patient datasets are well supported by breast cancer cell line models. We hypothesize from computational results that HSP90AA1 protein is an important nodal protein that oversees multiple signaling …