Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"endocardium"”.
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The Derivation of the Myocardial, Epicardial and Endocardial Lineages from Human Pluripotent Stem Cells
… lineages: the myocardium, the epicardium and the endocardium. The myocardium is the working muscle and comprises primarily the ventricles and atria. The epicardium represents the outer epithelial layer that surrounds the myocardium and plays a pivotal role during cardiovascular development. This …
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Coronary flow mechanics: an anatomically based mathematical model of coronary blood flow coupled to cardiac contraction
… linearly between ventricular pressure at the endocardium and atmospheric pressure at the epicardium. IMP and vessel stretch are included in the transmural pressure radius relationship to model the effect of myocardial deformation on coronary flow. The calculated coronary blood flow through the …
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An immunohistochemical assessment of endomyocardial biopsy specimens from the South African arrhythmogenic right ventricular cardiomyopathy registry
… up for these patients includes a biopsy of the endocardium which has historically been difficult to interpret and of limited value in the early stages of disease. This study will focus on novel immunohistochemical stains of the cardiac desmosomes. These will be used to try to aid in the early …
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Simulation Of The Undiseased Human Cardiac Ventricular Action Potential: Model Formulation, Experimental Validation And Application
… such a model using new experimental data from endocardium of 140 undiseased human hearts. 78 were from male: 56%). Average age was 41 with standard deviation of 12 years. New experiments include: Ca<sup>2+</sup> versus voltage dependent inactivation of L-type Ca<sup>2+</sup> current; kinetics …
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Age-associated changes to calcium handling proteins across the whole heart
… the former was further distinguished into the LV endocardium and epicardium. SERCA2a activity was significantly lower in the RV compared with the LV. Within the elderly age group RYR2, SERCA2a, PMCA4a all decreased in expression, whist NCX1 had elevated levels in the LV and RV. The changes in the …
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Advanced Deep Learning Approaches for Automated Assessment of Ultrasound Imaging (Lungs and Heart)
… of anatomical structures, including the endocardium, myocardium, and atrium of the left ventricle, which are essential for the measurement of clinical indices such as ejection fraction (EF). Despite the advancements in ultrasound technology, manual annotation remains the standard practice …
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MRI of structured-based ventricular mechanics
… at the epicardium to a right-handed helix at the endocardium. It also shows a septum-versus-free-wall polarization of sheet orientations, a pattern recently documented in canine hearts. Analysis of conjoint data of diffusion and strain gives a clear picture of myocardial structure-function …
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Cells of the Developing Human Heart and Great Vessels
… vessels. Chapter 6 explores the pericardium and endocardium as the two layers enveloping the myocardium. Ultimately, through the profiling obtained from the atlas, Chapter 7 proposes a framework to generate enhanced stem cell models to mimic the corresponding cells *in vivo*.
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Global sequence and dispersion of ventricular repolarization: In vivo validation of non-invasive parameters using monophasic action potential mapping technique
… from which the EOR times over the epi- (EORepi), endocardium (EORendo) and over both (EORtotal) were obtained- 12-lead ECG were recorded simultaneously. The QTpeak intervals were significantly smaller than the maximal EORepi. No significant difference was found between the maximal QTend interval …
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CyberCardia: Patient-specific electrophysiological heart model for assisting left atrium arrhythmia ablation
… atrium to map the atrium geometry and record endocardium electrograms that are then converted into electroanatomical maps to pinpoint the arrhythmia source locations. However, identifying these sources is challenging. The electrograms are asynchronous and can be susceptible to noise. The …
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Novel Phenotyping of the Myocardium by Diffusion Tensor Cardiovascular Magnetic Resonance
… in the epicardium through to right-handed in the endocardium) drives torsion. Sheetlets are aggregated cardiomyocytes that realign from wall-parallel in diastole, to wall-perpendicular in systole. This sheetlet mobility is integral to wall thickening. Diffusion tensor cardiovascular magnetic …
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Epicardial Wireless Pacemaker for Improved Left Ventricular Resynchronization (Conceptual Design)
… ventricle via transvenous leads anchored to the endocardium of the heart. The master device generates the pacing pulses to stimulate the right atrium and right ventricle and a communications module to transmit pacing commands to the epicardial satellite device. The epicardial satellite pacemaker …
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Functional and structural characterization of the mevalonate diphosphate decarboxylase and the isopentenyl diphosphate isomerase from Enterococcus faecalis
… gastrointestinal tract, the blood stream and the endocardium), and multidrug-resistant strains have become a serious issue across countries. Vancomycin, a FDA-approved drug for the disruption of the bacterial cell wall biosynthesis, has been utilized to treat infectious diseases caused by …
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Determinants of left ventricular mass as measured by Doppler echocardiography in pre-adolescents
… was measured from the septum edge to the endocardium mean border, (b) the posterior wall was measured as the distance from to anterior wall to the epicardium surface, and (c) the interventricular septum was quantified as the distance from the surface of the left ventricle border to the …
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Development of stainless cardiac histology of clinical biopsy samples with infrared spectroscopy
… tissue and to differentiate between fibrosis in endocardium with fibrosis in myocardium which stains similarly in hematoxylin and eosin stain (H&E). Repeated biopsy procedures can cause significant trauma to the patient, and often the surgeons require real time histopathology information of the …
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A Comprehensive Evaluation of Cardiac Electro-Anatomic Mapping Using Body Surface Potentials
… VT. Concurrent electrical activity from the LV endocardium was reconstructed using a multi-electrode balloon catheter. Finally, torso anatomies were acquired post-mortem with MRI and used to develop experiment-specific volume conductor models; a homogeneous model with isotropic electrical …