Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"endocannabinoid system"”.
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Targeting the Endocannabinoid System to Reduce Inflammatory Pain
<p>The endogenous cannabinoids (endocannabinoids) anandamide (AEA) and 2-arachidonylglycerol (2-AG) exert their effects predominantly through cannabinoid CB1 and CB2 receptors, but these actions are short-lived because of rapid hydrolysis by fatty acid amide hydrolase (FAAH) and monoacylglycerol …
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Role of the Endocannabinoid System in Cardiac Remodeling
The endocannabinoid system and CB1 and CB2 cannabinoid receptors have been implicated in cardiac remodeling with CB1 inhibition and CB2 activation reported to be beneficial. However, the role of these receptors in cardiac remodeling secondary to hypertension is not known. Moreover, the functions of …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… in the formation of memories and learning. Endocannabinoids (eCB) have recently emerged as important modulators of synaptic plasticity but their precise roles and mechanisms are not well understood and many contradictions exist in the current literature. We have investigated the roles of …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… in the formation of memories and learning. Endocannabinoids (eCB) have recently emerged as important modulators of synaptic plasticity but their precise roles and mechanisms are not well understood and many contradictions exist in the current literature. We have investigated the roles of …
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Blood Pressure Regulation by the Endocannabinoid System in Conditions Associated with Hypertension
… is mediated by an imbalance in autonomic nervous system activity. Baroreflex sensitivity for control of heart rate, an important index of vagus nerve function as well as general morbidity and mortality, is often impaired in conditions associated with hypertension. Restoration of baroreflex …
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Modulation of Fatty Acid-Induced Skeletal Muscle Inflammation by the Peripheral Endocannabinoid System.
The endocannabinoid system (ECS) has classically been known as a major neuromodulatory system of the central nervous system, in which endocannabinoids act as retrograde neurotransmitters that inhibit synaptic activity. However, recent evidence has indicated that the ECS may also play a key role in …
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Systemic Blockade of the Endocannabinoid System Alters Gene Expression and acquisition of a Hippocampus Dependent Learning Task
… the global and specific role of the cannabinoid system in altering gene expression. The current study examined the effect of continuous CB1 receptor antagonism on the expression of genes that influence learning and memory in the hippocampus as well as the ability of rimonabant to improve learning …
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A Phenomenological Inquiry into Healthcare Professionals Who Are Experts in Cannabinoid Therapy and the Endocannabinoid System (ECS)
… data has affected cannabinoid therapy and endocannabinoid system education (ECS) for healthcare professionals. There are gaps in medical school and continuing medical education initiatives despite the increase in cannabis consumption. As a result, healthcare professionals at all levels from …
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Investigation of chemotherapy-induced peripheral neuropathy-related behaviour in male and female ratsa role for the endocannabinoid system
… Accumulating evidence suggests that the endocannabinoid system represents a promising therapeutic target for CIPN, given its key role in pain regulation and the favourable tolerability profile of cannabinoids or endocannabinoid system modulators in patients with chronic pain. Both pain …
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Physical fitness and exercise as modulators of the endocannabinoid system in adults with mild-to-moderate depression the sonrie study
The endocannabinoid system (ES) is a lipid-based signaling network involved in multiple physiological processes including mood regulation, stress response, and neuroplasticity. The primary and most well studied endogenous ligands are anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These …
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Role of the Endocannabinoid System in Behavioral Reactions in a Depressive-Like Condition // Роля на ендоканабиноидната система в поведенчески реакции при депресивно-подобно състояние
Ендоканабиноидната система (ЕКС) е медиаторна система с липидни медиатори. Основните ѝ компоненти са канабиноидните рецептори (СВ1R и СВ2R) и ендоканабиноидите – N арахидоноилетаноламин (анадамид) и 2-арахидоноилглицерол. Участва в широк спектър физиологични процеси: ноцицепция, двигателен контрол, …
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Transition cows: hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition and the effects of genetic merit on genes of lipid metabolism in adipose tissue
… on transition cows to evaluate 1) hepatic endocannabinoid system gene expression in response to prepartal plane of nutrition. 2) effects of genetic merit on lipid metabolism in adipose tissue. For the objective of first experiment, we examined mRNA expression via qPCR of endocannabinoid …
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Studies to determine the mechanisms of the anti-atherosclerotic effects of eicosapentaenoic acid: possible role for endocannabinoids?
… intake of ω-3 PUFAs alters the concentration of endocannabinoids (ECs) in central and peripheral tissues and, since synthetic cannabinoid agonists have been shown to exert anti-atherosclerotic effects, this thesis explored whether a link exists between the endocannabinoid system and the …
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Synthesis of fluorinated cannabinoid derivatives; Towards PET radiotracers for imaging the cannabinoid receptor
Efforts toward understanding the endocannabinoid system, which is comprised of cannabinoid receptors and endogenous ligands, have rapidly expanded in recent years. The endocannabinoid system can modulate the activity of other neurotransmitters through the type 1 cannabinoid receptor (CB1R) which is …
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Possibile ruolo del sistema endocannabinoide nel disturbo d’alimentazione incontrollata (binge eating disorder): studi comportamentali, farmacologici e biochimici
… body of evidence supports a contribution of the endocannabinoid system in the modulation of energy balance by controlling food intake through central and peripheral mechanisms. The cannabinoid CB1 receptor is abundantly expressed in the central nervous system and induces inhibition of …
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Studies on the role of the endocannabinoid anandamide, as a possible modulator of events during neointimal formation.
… drive the formation of a neointima. Cannabinoids/endocannabinoids have been shown to elicit antiproliferative, anti-migratory and anti-inflammatory effects, highlighting modulation of the endocannabinoid system as possible therapeutic strategy. The aims of this study were to; (i) develop an organ …
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The endocannabinoid system in critical neurodevelopmental periods: Focus on its role in the pathophysiology of schizophrenia as neurodevelopmental disorder [Il sistema endocannabinoide nei periodi critici del neurosviluppo: Focus sul suo ruolo nella fisiopatologia della schizofrenia come disturbo dello neurosviluppo]
… prove a sostegno del coinvolgimento del sistema endocannabinoide nella fisiopatologia della SCZ, questa tesi si è posta l’obiettivo di studiare il ruolo del sistema endocannabinoide (EC) nello sviluppo cerebrale e il potenziale terapeutico della modulazione farmacologica precoce del sistema …
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Endocannabinoid and lipid metabolism genes network analysis in adipose and liver tissue of dairy cows during the transition period
… 1) effects of body condition score (BCS) on the endocannabinoid system and lipid metabolism gene expression in adipose tissue; and 2) effects of rumen-protected methionine on the endocannabinoid system in liver tissue. In the first study, cows were retrospectively classified according to their …
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Cell-type specific CB1 receptor modulation of hippocampal synaptic plasticity and memory
The endocannabinoid system is a major brain modulatory system that controls memory and learning mainly via the cannabinoid receptor type 1 (CB1)-dependent regulation of neuronal and glial activity. In the hippocampus, bidirectional communication between neurons and astrocytes shapes synaptic …
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