Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"end-stage disease"”.
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A mathematical analysis of the financial and medical impact of hepatitis C among drug users in Perth, Western Australia
… by uncertainties encountered with transmissible diseases. Key epidemiological factors such as, how many Western Australian injecting drug users are hepatitis C seropositive or will become infected, duration of intravenous drug use, the intensity of infection, the fraction of those infected that …
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Investigating the Fate of Pre-neoplastic Cells in a Mouse Model of Medulloblastoma
<p>Studying the early stages of cancer can provide important insight into the molecular basis of the disease. In many human cancers, such as prostate, pancreatic, and colon cancer, a pre-neoplastic, or intermediate, stage of the disease has been identified. The pre-neoplastic stage is presumed to …
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Developing an induced pluripotent stem cell model of pulmonary arterial hypertension to understand the contribution of BMPR2 mutations to disease-associated phenotypes in smooth muscle cells
… responsible for the manifestation of clinical disease. Furthermore, limited human tissue is available for study and usually only from patients with end-stage disease, making it difficult to understand how PAH is established and progresses. Alternative human models of PAH are therefore required. …
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Intrahost evolution of HIV-1 phenotypes
… evolves in the newly infected host and during disease progression, we may develop better therapeutics and perhaps halt the spread of the virus. This thesis is based on studies in which we have investigated how HIV-1 phenotypically evolves within infected individuals. We studied viruses emerging …
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Spinal cord pathology of ovine CLN5 and CLN6 neuronal ceroid lipofuscinoses (Batten disease) : A thesis submitted in partial fulfilment of the requirements for the Degree of Master of Agricultural Science at Lincoln University
Neuronal ceroid lipofuscinosis (NCL or Batten disease) is a fatal neurodegenerative disorder, which occurs in approximately 1 in 12,500 children worldwide and currently has no cure. To date, there are thirteen known variants of NCL, caused by mutations in the genes CLN1-8 or CLN10-14. Two naturally …
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Role of endogenous retrovirus in control of feline leukemia virus infection and implications for cross species transmission
Endogenous retroviruses (ERV) are markers of ancient retroviral infections, though evolutionary forces have limited the capacity for ERV replication and virulence. While they are seldom considered infectious alone, they maintain the ability to interact with their exogenous retroviral (XRV) …
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Exogenous mesenchymal stromal cells in osteochondral repair
… in OA and current clinical management for end-stage disease remains joint replacement surgery. There is therefore a need for a change in healthcare strategies to manage early disease, a shift that is likely to include cell-based regenerative therapies. Regenerative medicine and cell …
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HOPE Desarrollo de una metodología piloto para vinculación a Clinical Trials como herramienta de medicina basada en evidencias, para proporcionar medicina centrada en el paciente
Desarrollo de una metodología piloto con vinculación a Clinical Trials como una herramienta de medicina basada en la evidencia con medicina centrada en el paciente. Se desarrolló una metodología de búsqueda automatizada de información en la url de clinical trials. Con la colaboración de médicos …