Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"end organ damage"”.
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Status of end organ damage in newly detected hypertension, hypertension in thyroid disorders and knowledge and awareness of hypertension among physicians and public
Hypertension is associated with end organ damage (EOD). Since EOD is a risk factor for cardio- and cerebrovascular complications, it is a major requirement for these to be detected, prevented and treated. A total of 147 consecutive patients with newly-diagnosed essential hypertension and attending …
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The Dendritic Cell Response to Exogenous and Endogenous Danger Signals
… in the vasculature, and cause multisystem organ damage. Both genetic and environmental factors contribute to the development of SLE. This thesis will explore three major themes found in the study of SLE: 1) Bacterial infection as an environmental trigger, 2) cytokine dysregulation in immune …
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Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis
… dysfunction, caused cardiovascular remodeling, endothelial dysfunction, increased vascular reactivity and compromised renal hemodynamics in cPLA2α+/+ mice; these changes were diminished in cPLA2α-/- mice. Ang II also increased cardiac and renal infiltration of F4/80+ macrophages and CD3+ T …
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The effect of single nucleotide polymorphisms and mutations on congenital thrombotic thrombocytopenic purpura phenotype
… thrombi in the microcirculation, leading to end-organ damage. TTP is a clinically heterogeneous disorder caused by autoantibody inhibition or clearance or by a deficiency in activity or secretion of the von Willebrand factor cleaving protease (ADAMTS13). Over 100 mutations have been …
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Role of Bruton’s Tyrosine Kinase and Interleukin-6 in Plasma Cell Accumulation and Autoantibody Production in Lyn-Deficient Mice, A Model of Lupus
… immune complex deposition, inflammation, and end organ damage such as glomerulonephritis (GN). Currently, only non-specific, immunosuppressive therapies are approved for use in lupus patients. These have undesirable side effects and risks. The development of more targeted therapies is …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Vascular Fetal Programming in a Mouse Model of Preeclampsia
… circulation, causing dysfunctional maternal endothelium, and resulting in blood pressure increase and end organ damage. Pregnancies destined to develop preeclampsia have altered cardiovascular adaptations which results in endothelial dysfunction, and abnormal placental perfusion. Various …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Fetal Vascular Programming in a Mouse Model of Preeclampsia
… circulation, causing dysfunctional maternal endothelium, and resulting in blood pressure increase and end organ damage. Pregnancies destined to develop preeclampsia have altered cardiovascular adaptations which results in endothelial dysfunction, and abnormal placental perfusion. Various …
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biological treatment options of multiple myeloma
… malignancies and is characterised by end organ damage and the presence of bone lesions. Currently, myeloma therapies involve the use of combinations of multiple agents from various classes. These include proteosome inhibitors, monoclonal antibodies, Chimeric antigen receptor T cells, T …
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Managing alloimmunization, delayed hemolytic transfusion reactions, and hyper-hemolysis in sickle cell disease
… destruction of RBCs. Other morbidities include end-organ damage, pain attacks known as “sickle cell crisis,” bacterial infections, and stroke. Transfusion therapy remains a necessary treatment of sickle cell disease. Transfusions given to lower the levels of sickle RBCs and viscosity have shown …
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EXERCISE BLOOD PRESSURE IN ADOLESCENCE AND BLOOD PRESSURE FIVE YEARS LATER IN PERSONS BORN WITH VERY LOW BIRTH WEIGHT
… is extremely important to prevent or minimize end-organ damage. Although resting blood pressure (BP) is found to be a good predictor of future resting BP, the addition of BP response to an exercise stressor may further enhance the ability to predict future levels of resting BP in both …
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Cardiovascular magnetic resonance characterisation of the phenotype of resistant uncontrolled hypertension
… heart disease, chronic kidney disease leading to end-stage renal disease, stroke, vascular dementia, CV death and peripheral arterial disease. A proportion of patients with RH who never achieve BP control despite maximal medical treatment, represent a potentially novel and distinctive phenotype …
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Blood Pressure, Arterial Stiffness and Cardiovascular Risk Prediction
… 130mmHg in line with the US guidelines as recommended by the AHA/ACC. This would dramatically increase the number of adults requiring drug therapy. Aortic stiffness is an attractive novel biomarker, particularly for those with borderline hypertension, because it can be measured simply and …
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Harnessing Systems Bioengineering Approaches to Study Microbe-Microbe and Host-Microbe Interactions in Health and Disease
… where the survival of the prey species is dependent on the location (distance from the killer) or the evolution of resistance. The importance of this work lies in the context of the evolution of antibiotic-resistant bacterial strains and in understanding the communication between the microbial …