Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"end‑protection"”.
-
Investigating Mechanisms of Telomere End-Protection
… conserved shelterin component, Rap1, to telomere endprotection. Rap1 was first discovered in budding yeast as a transcription factor and was later shown to bind directly to telomeres. Two important functions of Rap1 in yeast are: the negative regulation of telomere length, and the inhibition of …
-
Mechanisms of Telomere End Protection by TRF2
… a six-subunit protein complex that protects the ends of mammalian chromosomes, called telomeres. The six subunits of shelterin, TRF1, TRF2, TIN2, TPP1, POT1, and Rap1, each have distinct roles in telomere homeostasis. These include telomere length regulation and preventing telomeres from …
-
Testing the T-loop Model of Telomeric End Protection
… are the key structures that protect the ends of linear chromosomes. Although they are often thought about in the context of cellular aging, their most important role is actually to protect the end of the DNA from being mis-interpreted as a site of DNA damage. Telomeres are thought to …
-
Mechanisms That Ensure the Proper Terminal Structure of Mammalian Telomeres
… 3' overhang, a conserved feature at the ends of linear chromosomes, is thought to contribute to the important functions of end protection and telomere length homeostasis. Here, I investigated the mechanism by which the overhang is generated and maintained at mammalian telomeres. First, I …
-
Investigating The Role of Abro1 In Dna Damage-Induced Immune Response
… fork, genome stability is maintained by fork end protection and subsequent restart of the replication. Abro1 has been shown to play an important role in protecting the integrity of the stalled replication forks by inhibiting DNA2 nuclease. Deficiency of Abro1 leads to stalled replication fork …
-
The Role of ZMYND8 in Immunoglobulin Class Switch Recombination
… DNA Damage Repair (DDR) pathway, non-homologous end-joining (NHEJ). Critical components of CSR are 53BP1 and its effector RIF1 because they inhibit end resection to promote NHEJ and oppose competing pathways in DDR. However, the mechanism by which RIF1 effects end-protection in CSR and binds to …
-
Defining Multiple Steps in Human Telomere End Processing
Telomere overhangs are essential for chromosome end protection and telomerase extension, but how telomere overhangs are generated is unknown. Due to the classic end replication problem, leading DNA daughter strands are initially blunt while lagging daughters are shorter by at least the size of the …
-
53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis
… cancers. Additionally, 53BP1 promotes end-to-end fusions of telomeres lacking end protection from the shelterin component TRF2, and facilitates end-joining at programmed breaks generated during class switch recombination in the immune system. The role of 53BP1 in double strand break …
-
Modeling Sporadic Tumor Formation Driven By Telomere Dysfunction In The Gastrointestinal Tract
… telomeres. Telomeres comprise the linear ends of chromosomes and play a dual role in cancer. Its length is maintained by the ribonucleoprotein, telomerase, which is not a normally expressed in somatic cells and as cells divide, telomeres continuously shorten. Critically shortened telomeres …
-
Neotelomere Formation by Telomerase in Human Cells
<p>Telomeres define and protect the ends of linear chromosomes. Genome stability requires that cells differentiate telomeres from DNA double-strand breaks (DSBs), which humans accomplish with the shelterin complex. The reverse transcriptase telomerase counteracts the shortening of telomeres that …
-
Il procedimento amministrativo digitale: la semplificazione al servizio dell’amministrazione e del cittadino
… and continuing centrality in the political agendas of different national legal systems: the procedural simplification that can be ascribable to the species of interventions that belong to the broader genus of the change of public administration’. Since the ‘70s, the transformation of public …