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Showing 1 to 14 of 14 for “"enalapril"”.
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The development, validation, and evaluation of quantitative assays for determining adherence of heart failure patients to carvedilol, enalapril and perindopril
… assays were developed to quantify carvedilol, enalaprilat and perindoprilat in dried blood spots (DBS) and correlated with plasma. Carvedilol, enalapril and perindopril are medications commonly used to treat HF, with enalaprilat and perindoprilat being the active metabolites of enalapril and …
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Pilot comparison of clinical effects and compliance with commonly prescribed antihypertensive drugs in HIV hypertensive patients at University Teaching Hospital
… on CCB (140.4/98.8 mmHg) and CCB with Enalapril (147.9/92.7 mmHg) had higher median daytime blood pressure than Moduretic (136.8/84.2 mmHg, p=0.186 and 0.168 respectively) and Moduretic with Enalapril (140.5/84 mmHg, p= 0.003). The attributable risk for good daytime systolic and …
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Pilot comparison of clinical effects and compliance with commonly prescribed antihypertensive drugs in HIV hypertensive patients at University Teaching Hospital
… on CCB (140.4/98.8 mmHg) and CCB with Enalapril (147.9/92.7 mmHg) had higher median daytime blood pressure than Moduretic (136.8/84.2 mmHg, p=0.186 and 0.168 respectively) and Moduretic with Enalapril (140.5/84 mmHg, p= 0.003). The attributable risk for good daytime systolic and …
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Rat angiotensin-converting enzyme : tissue specific expression during pharmacological inhibition
… aldosterone. ACE inhibitors, such as captopril, enalapril and lisinopril, are highly effective in the treatment of hypertension and congestive cardiac failure. Previous studies have suggested that angiotensin converting enzyme (ACE) production may be enhanced during pharmacological inhibition of …
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Central autonomic control in spontaneously hypertensive rats: a study on phasic phenomena during rapid-eye-movement sleep
… an angiotensin converting enzyme inhibitor, the Enalapril maleate, from the age of four weeks to the end of the experiment. All rats were implanted with electrodes for electroencephalographic and electromyographic recordings and with an arterial catheter for arterial pressure measurement. After …
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Manipulating the mechanical strength and biological stability of collagen-based scaffolds for tissue engineering
… potential of the ACE inhibitors captopril and enalapril to inhibit enzymatic collagen degradation, and ultimately slow down the rate at which collagen is degraded by cells of the body. Both captopril and enalapril were shown to inhibit enzymatic collagen degradation in a dose-dependent manner, …
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Pharmacometrics to characterize pharmacokinetics and optimize treatment in understudied populations
… a model-based adherence monitoring tool using enalapril, an angiotensin-converting enzyme inhibitor for hypertension and heart failure, in a small cohort of African heart failure patients, and characterizing pharmacokinetics of esomeprazole, a proton pump inhibitor for hyperacidity and being …
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Chronotropic Incompetence in Patients with Heart Failure and a Preserved Ejection Fraction: Prevalence and Impact on Exercise Tolerance
… a four month aerobic intervention, as well as an enalapril and a spironolactone intervention on the prevalence of CI in HFrEF patients. METHODS: Prevalence and impact of CI on exercise tolerance was evaluated in 207 HFpEF subjects from three previously conducted studies (PARIS II, PIE I, PIE II). …
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Sympathetic Innervation of the Rat Adrenal Cortex and Its Effects on the Compensatory Adrenal Cortical Growth Response to Unilateral Adrenalectomy (Catecholamine, Endocrine, Splanchnic Nerve, Cell Proliferation)
… of angiotensin II and III synthesis with Enalapril (20 mg/kg orally) did not affect compensatory adrenal growth. Furthermore, potassium-induced stimulation of aldosterone secretion did not prevent the increase in adrenal DNA content associated with compensatory growth. Compensatory adrenal …
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Pharmacogenetics of resistant hypertension: evaluating the role of genetic variation in ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B among South African hypertensive patient
… of antihypertensive drugs such as amlodipine, enalapril or spironolactone, increasing their exposure and efficacy. NOS3 rs3918188A allele may affect NOS3 gene expression, or its effect may be due to variants in linkage disequilibrium with it, leading to increased efficacy of antihypertensives …
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… p=1.01×10-5, with similar results seen for enalapril and lisinopril and with other CYP2D6 variants.I have also detected two other novel findings with directionally consistent results in the replication cohort with p-values close to significance levels (amlodipine- rs868853 (ABCC4)-lower odds …
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Flow Chemistry Guided by Computer-Aided Synthesis Planning
… enzyme inhibitors, including quinapril and enalapril. This strategy was informed by ASKCOS, a computer-aided synthesis program, and developed manually using bench-top flow reactors as well as batch chemistry techniques. An optimization effort guided by in situ Fourier-transform infrared …
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Acer, a homologue of the human angiotensin-1 converting enzyme, modulates the response of sleep, glycogen storage, lifespan, fecundity and stress resistance to diet in Drosophila melanogaster
… when rats were treated with the ACE inhibitor Enalapril (Santos, et al., 2009). Currently ACE’s role in this tissue is unknown and therefore the study of the Drosophila homolog ACER, which is expressed within the fly fat body which is similar in structure to human adipose cells, may highlight a …
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Toxicology and herb-drug interaction of selected anti-hypertension plants used by lay persons in Northern KwaZulu-Natal (South Africa)
… aluminum hydroxide, amlodipine, aspirin, enalapril, pharmapress and ridaq). The three assays applied were the CYP3A4 inhibition assay, the beta-glucuronidase inhibition assay as well as the carboxylesterase inhibition assay. These assays were chosen according to the enzymes involved in the …