Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"embryonic patterning"”.
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The Role for Proteoglycans in Regulating Embryonic Patterning and Morphogenesis
Growth factors and morphogens regulate embryonic patterning, cell fate specification, cell migration and morphogenesis. The activity and behaviour of these signalling molecules is regulated in the extracellular space through interactions with proteoglycans. Proteoglycans are high molecular-weight …
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Germline development in Platynereis dumerilii and its connection to embryonic patterning
… and its correlation with pluripotency and embryonic patterning in the polychaete Platynereis dumerilii, an emerging model system that is well suitable for comparative developmental studies across Bilateria. In the first section, I describe the germline development of Platynereis with the …
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Characterisation of the role of Sox4 in mouse embryonic development
… Many proteins, in pathways critical for correct embryonic patterning, are thus also identified as playing a role in aspects of heart development. A developmental role for Sox4 has been shown in mouse cardiogenesis, as apparent by the phenotype of two published alleles. Both null and conditional …
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Transcriptome-wide organization of subcellular microenvironments revealed by ATLAS-Seq
… ranging from cell fate determination and embryonic patterning to local translation and directed cell movement. Elegant efforts focused on a small handful of RNAs have established RNA localization to play key roles in cell function - yet recent studies suggest that specific localization …
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Dact Family Molecules In Wnt Signaling In Mouse Development
… pathways are known to be integral in the embryonic patterning of multicellular animals, and are misregulated in multiple types of cancer. Wnt signaling includes multiple biochemical signaling pathways downstream of the Wnt family of secreted proteins and their receptors. Many, and possibly …
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Investigation of cell movement and the associated cytoskeleton during chick gastrulation and somitogenesis
… influences the fate of cells during early embryonic patterning, cell movement, and cell polarity, processes in which the cytoskeleton is noticeably modified. The microtubule and actin crosslinking factor-1/actin crosslinking factor-7 (MACF1/ACF7) protein has been implicated in Wnt …
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Investigating The In Vivo Role Of Wnt Acylation
… family of morphogens that play diverse roles in embryonic patterning, the maintenance of adult stem cells, and the evolution of cancers. Mammalian genomes contain 19 unique Wnt proteins which undergo post-translational acylation at a highly-conserved serine residue. All Wnts bind to the Frizzled …
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Regulation of Wingless secretion, distribution and signaling
… cysteine-rich glycoproteins essential for embryonic patterning and adult homeostasis. Wnt signaling is highly regulated in all aspects, including the biogenesis and processing of active Wnt ligands, Wnt secretion and gradient formation on the cell surface and in the extracellular matrix, …
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The cellular and molecular investigation of Wnt/FZD signalling during spinal cord neurogenesis
… has been studied extensively and is a model for embryonic patterning and cell differentiation. These processes are governed by extracellular and intracellular signaling and require gene transcription. Wnt signaling has been shown to be involved in dorsal-ventral patterning of the spinal cord, …
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Analysis of embryonic development in Tribolium castaneum using a versatile live fluorescent labelling technique
… arthropod models are shifting our knowledge of embryonic patterning and morphogenesis beyond the Drosophila paradigm. In contrast to Drosophila, most insect embryos exhibit the short or intermediate-germ type and become enveloped by extensive extraembryonic membranes. The genetic basis of these …
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Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling
… factors (Fgfs) are involved in the molecular patterning of various tissues, including two regions of the brain, the forebrain and the midbrain-hindbrain region, affecting cellular processes as diverse as cell proliferation, differentiation, and axonal targeting. The goal of this study was to …
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Investigating the role of Notch signalling during mesoderm development and cell proliferation
… known to govern mesoderm specification and early embryonic patterning. Secondly, we used human cell lines to generate novel molecular tools that allowed the visualisation of Notch1 target gene, c-MYC, RNA and proteins endogenously in real-time. Using these tools, we found that Notch1 interacts …
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NOGGIN Transport in a Model Human Epiblast
… within our model of the polarized human embryonic disc. Here, I report the surprising discovery that in human epiblasts, NOGGIN and BMP4 were selectively secreted into opposite sides of the polarized epithelium, effectively segregating the ligand and its inhibitor into distinct …