Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"embryo toxicity"”.
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The fathead minnow embryo as a model for the development of alternative testing methods in ecotoxicology.
… and a timeline for normal development of the embryo was established. Results showed only minor differences to already existing studies (Devlin et al. 1996, Manner and Dewese 1974). Based on fathead minnow-specific developmental data, the embryo toxicity test was adapted and refined. Using the …
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Ecotoxicogenomic New Approach Methods for Screening Development in Danio rerio
… and mechanistic insights into chemicals toxicity. <br /> This research concentrates on two primary areas: the mode of action-based screening of thyroid active and immunotoxic compounds, and the application of the transcriptomic point of departure (tPOD) method as an alternative for …
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Developmental Malformations in Zebrafish Caused by Exposure to Environmental Pollutants
… released to the environment with little to no toxicity information. Exposure to these chemicals is identified as one of the risk factors for causing birth defects. We used zebrafish as a model to identify and predict environmental chemicals causing congenital malformations. High-throughput …
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The distribution of different fluorescence dyes in the egg and embryo of the zebrafish (Danio rerio)
The fish embryo test (FET) with Danio rerio is a well-established method for the toxicological evaluation of treated waste water, chemicals and sediments and was standardized at a national level in DIN 38415-6 in 2001. In order to study the distribution of chemicals in the FET, the present study …
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Quantification, phase distribution, and persistence of antiretroviral drugs in wastewater treatment systems and their ecotoxicological impacts in aquatic environments
… magna immobilisation and Danio rerio fish embryo toxicity tests). Behavioural endpoints, such as changes in zebrafish larval activity, were the most sensitive indicators of ARV impact, identifying effects at concentrations below the detection threshold of standard ecotoxicity assays. These …
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Examining swim bladder inflation failure as a toxicological endpoint in Japanese medaka (Oryzias latipes)
… is important. This study demonstrated that embryonic exposure to the pharmaceuticals 17α-ethinylestradiol, levonorgestrel, and diclofenac, impaired swim bladder inflation of Japanese medaka (Oryzias latipes). After exposure to individual compounds, mixture exposures to no-observed-effect …
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Combined effects of bioavailable organic contaminants in the aquatic environment.
… overcome many of the challenges associated with toxicity testing of hydrophobic substances, which can bias the interpretation of toxicity data. The present study investigated the feasibility of coupling silicone rubber passive sampling devices (SR-PSDs) with bioassay techniques for both chemical …
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Development and Evaluation of 3D-Printed Cardiovascular Stents
… in vitro cell culture studies and zebrafish embryo model. The percentage changes in volume of stents fabricated using HEMA and HEMA-0.35MeGO were 36.7±4.7% and 7.7±1.6%, respectively after 24 hr. The remaining fractions of 3D stents after 21 days and their corresponding first-order …
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Characterising the functional homology of central nervous system drug targets in larval zebrafish (Danio rerio)
… which currently rely largely on apical toxicity endpoints and consider pharmacological mode of action to a lesser degree. This thesis investigates whether conservation of CNS drug targets in fish predicts functional effects, using larval zebrafish (Danio rerio) as a model system. The …
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Chemical-sensitive genes in zebrafish (Danio rerio) early development - identification and characterisation of differential expression in embryos exposed to the model compound 3,4-dichloroaniline
… of potential hazardous substances, various ecotoxicity tests are performed, including acute and chronic fish tests. As a consequence of the new program of the European Union “Registration, Evaluation and Authorisation of Chemicals” (REACH) the number of animal experiments for environmental risk …