Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"elongation factor G"”.
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Single Molecule Förster Resonance Energy Transfer and Super Resolution Force Spectroscopy Study of Elongation Factor G Evolution, Conformation, and Function
… mRNA facilitated by a translocase enzyme, elongation factor G (EF-G). EF-G induces the advancement of the mRNA reading frame by 3 nucleotides (nt) and tRNA translocation via the hydrolysis of one GTP molecule. The mechanism of this reaction remains largely unknown. Cryo-EM studies indicated …
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Semi-synthesis and evaluation of fusidic acid derivatives as potential antituberculosis agents
… of protein synthesis via binding to bacterial elongation factor G (EF-G). Fusidic acid has also been reported to possess in vitro antimycobacterial activity but was subsequently found to lack in vivo efficacy in a mouse model. Towards contributing to new antimycobacterial agents, this study …
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The impact of a single nucleotide polymorphism in fusA1 on biofilm formation and virulence in Pseudomonas aeruginosa
… was identified within the gene, fusA1, encoding elongation factor G (EF-G). The mutation introduced minor structural changes to the protein which were likely to have functional repercussions in its involvement in protein synthesis. Phenotypic analysis revealed that the mutation conferred changes …
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Integrated cellular, proteomic and metabolite analysis of argyrin B with rational design approaches for immunoproteasome-selective inhibitors
… targeting of the proteasome and mitochondrial elongation factor G; both integral to proteostasis. Further to this, argyrin B analogue has shown potential for selective inhibition of the β1i site of the immunoproteasome. This thesis extents studies on argyrin analogues as potential proteasome …
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Isolation and characterization of African marine natural products and repositioning of the natural product antibiotic fusidic acid and privileged benzimidazole scaffold for tuberculosis and malaria
… of Mycobacteria tuberculosis and P. falciparum elongation factor G (EF-G), the current work expanded the structure-activity relationship (SAR) explorations in the medicinal chemistry approach of repositioning for tuberculosis and malaria. Twenty-nine (29) fusidic acid C-21 ethanamides, anilides …
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An exploratory study of Helicobacter suis control strategies
… for humans. H. pylori uses a variety of factors to persistently colonize the gastric mucosa and to induce gastric pathologies in humans. For a long time, the lack of pure H. suis in vitro isolates hampered the progress of research on this bacterium. At the start of this thesis, virtually …