Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 634 for “"elegans"”.
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Starvation Response in Caenorhabditis elegans
… act to promote survival in Caenorhabditis elegans during starvation, whereas insufficient or excessive levels of autophagy contribute to death. I find that inhibition of autophagy decreases survival of wildtype worms during starvation. Furthermore, I find that in gpb-2 …
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Serotonin signaling in C. elegans
Wild-type animals that have been acutely food deprived slow their locomotory rate upon encountering bacteria more than do well-fed animals. This behavior, called the enhanced slowing response, is partly serotonin (5-HT) dependent. Animals mutant for the 5-HT reuptake transporter gene mod-5 slow …
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mRNA localization in Caenorhabditis elegans embryogenesis
… questions, this thesis defines Caenorhabditis elegans as a model organism for exploring mRNA localization, its mechanisms, and its functions with a focus on condensate transcripts. Thus, the discoveries made have contributed to the fields of post-transcriptional gene regulation, mRNA …
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Sensory Organ Morphogenesis in Caenorhabditis Elegans
… I use the main sensory organ of Caenorhabditis elegans, the amphid, as a model system for understanding how glia form these compartments. First, by the interpretation of electron microscopy reconstructions of the developing amphid, I was able to uncover a role for daf-6/Patched, an established …
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Aversive Olfactory Imprinting in Caenorhabditis Elegans
… underpinnings of imprinting. I have used C. elegans as a model organism to study imprinting because of its compact and well characterized nervous system, an armory of available genetic tools, and a versatile behavioral repertoire. Using a ethologically relevant training regime, I found that …
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Density-Dependent Foraging in Caenorhabditis Elegans
… predictions are met by foraging Caenorhabditis elegans. In Chapter 2, I show that animals alter their foraging behavior in response to population density, that certain pheromones induce this behavioral change, and that different wild isolates vary in response to the potent ascaroside icas#9. I …
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Tools for connectomics in C. elegans
… the 302-node nervous system of the nematode C. elegans and its transparency have made it an attractive model organism in neuroscience for several decades. Indeed, Caenorhabditis elegans has long been touted as the only species for which the connectome is known, reconstructed by hand from …
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Modeling neural connectivity of caenorhabditis elegans
… to apply these methods to data recorded from C. elegans neurons and estimate the connections between these. The top two performing methods on simulated data were feed-forward neural networks and ODE reverse engineering. The worst performing methods were recurrent neural networks and Bayesian …
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Tools for Behavioral Phenotyping of C. elegans
… behavior and the brain is the nematode C. elegans. However, current phenotyping tools have technical limitations that make observing, intervening in, and quantifying behavior in diverse settings difficult. In this thesis, I develop enabling technological systems to resolve these challenges. …
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Analysis of Zinc Transporters in C. elegans
… To address these questions, we used C. elegans as a model system. While three C. elegans cdf genes have been characterized previously, the majority of zinc transporters remain to be studied. Here, we characterized cdf-2 and ttm-1 and conducted initial studies of other zinc transporters. …
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Mechanisms of Olfactory Plasticity in Caenorhabditis Elegans
… and an armory of molecular and genetic tools, C. elegans is well-suited for the study of experience-dependent plasticity. Using an olfactory adaptation paradigm in which animals lose attraction to butanone after it is paired with starvation, I here describe neuronal and molecular mechanisms that …
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An Analysis of Synaptotagmins in Caenorhabditis Elegans
… of the synaptotagmin family in Caenorhabditis elegans. Synaptotagmins are best known as the calcium-sensing proteins for regulated synaptic vesicle exocytosis. I examined the effects of this lesion on a number of sensory neurons and motor neurons, in order to ascertain the uniformity of the …
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Autophagy and Lipid Homeostasis in C. elegans
… lipid storage and breakdown. The nematode C. elegans is an ideal model to address the fundamental mechanisms that underlie lipid homeostasis in an intact organism. We discovered that autophagy gene activity (unc-51/ULK1/2, bec-1/BECN1, vps-34/VPS34, and lgg-1/LC3I) is required for neutral …
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Temporal Processing by Caenorhabditis elegans Sensory Neurons
Caenorhabditis elegans is a promising organism for trying to understand how nervous systems generate real-time behavior. Its low neuron count suggests that we may be able to observe all of the constituents of the computation of sophisticated sensorimotor behavior. However, its appropriateness as a …
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Modulation of touch sensitivity in Caenorhabditis elegans
… this thesis, I study mechanosensation in the C. elegans touch receptor neurons (TRNs) to understand how sensory systems are modulated and adapt to the environment. I find that the touch sensitivity in the TRNs is modulated by both mechanical and non-mechanical factors. The mechanical factors are …
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Double-stranded RNA uptake in Caenorhabditis elegans
… pest control. In the nematode Caenorhabditis elegans, a transmembrane protein named systemic RNAi deficient-2 (sid-2) is required for dsRNA uptake from the environment through the intestine. Furthermore, the tyrosine-protein kinase sid-3 promotes import dsRNA. However, the molecular mechanism …
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Serotonin-dependent modulation of Caenorthabditis elegans behaviors
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 2001.
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Host-Bacteria-Virus Interactions in Caenorhabditis elegans
… and the experimental tractability of the C. elegans host enables the study of the determinants of virus transmission. Studies from mice and insects have demonstrated that bacteria influence viral infection and transmission. Here we used Caenorhabditis elegans and Orsay virus to screen a panel …
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Developing a Caenorhabditis elegans Model for Marfan Syndrome
… objective of this study was to establish a C.elegans MFS model and use this model to determine which genes interact with a C.elegans fbn1 homolog, MUA-3 and ascertain the role of metabolic rate in the development of MFS pathology. We isolated a temperature sensitive mutant of mua-3, a fbn1 …
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