Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"electrospray ionization (ESI)"”.
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Linear state-space analysis and optimization of StreamIt programs
The following thesis entails the construction, testing, modification, and analysis of two systems that couple sample ion introduction methods with a Differential Mobility Spectrometer (DMS). The sample ionization methods used with a custom designed interface for the DMS were Electrospray Ionization …
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Characterization of AP-MALDI and ESI for a differential mobility spectrometer
The following thesis entails the construction, testing, modification, and analysis of two systems that couple sample ion introduction methods with a Differential Mobility Spectrometer (DMS). The sample ionization methods used with a custom designed interface for the DMS were Electrospray Ionization …
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From Solution Into the Gas Phase: Studying Protein Hydrogen Exchange and Electrospray Ionization Using Molecular Dynamics Simulation
… contexts. We next use MD to examine the Electrospray ionization (ESI) mechanism of proteins. ESI is a soft ionization technique resulting in the production of gaseous protein ions. The mechanism of ion formation from nanometer sized droplets is unclear. We apply a trajectory stitching MD …
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Surface Acoustic Wave Nebulization as a Mass Spectrometry Ionization Source, Characterization and Application
… energy distribution of SAWN is lower compare to electrospray ionization (ESI). To improve the SAWN performance, a standing wave SAWN chip was designed and fabricated. The droplet size of standing wave SAWN was measured and is in general smaller than progressive wave SAWN. The standing wave SAWN …
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Numerical optimization of ion transport in electrospray mass spectrometry
Electrospray ionization (ESI) has developed into a key component of investigative analyses of samples in numerous biological, chemical, and geological contexts due to its unique ability to preserve the structure of ionized species without fragmentation. It is thus important that we fully understand …
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Protein Structural Studies by Oxidative Labeling and Mass Spectrometry
… chemistry. Oxidative labeling combined with electrospray ionization (ESI) mass spectrometry (MS) offers enormous opportunities for studying protein structures at the level of individual residues. Such high selectivity combined with excellent sensitivity makes ESI-MS a primary tool for the …
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Development Of Matrix Assisted Ionization Methods For Characterization Of Soluble And Insoluble Proteins From Native Environments By Mass Spectrometry
<p>Matrix-assisted laser/desorption ionization (MALDI) and electrospray ionization (ESI) have made a huge impact in the analysis of biological materials. ESI has gained its popularity involving liquid based analysis, efficient fragmentation, chromatographic and electrophoretic separations but has a …
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Distinguishing Macrophage Activation States by Mass Spectrometry
… homeostasis or regeneration, as well as pathogenesis. They react to their microenvironment, assuming various roles based on chemical and/or physical cues, and can reversibly shift between these so-called activation states. Concurrently, the technique of immunohistochemistry is used to gain …
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Development Of Inlet And Vacuum Ionization Methods For Characterization Of Biological Materials By Mass Spectrometry
<p>Inlet ionization and vacuum ionization are novel ionization methods to produce electrospray ionization (ESI)-like ions from the solid or liquid states, operating from atmospheric pressure (AP) or vacuum, without the use of voltage or the necessity of high energy input such as a laser or particle …
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Microfluidic Interfaces for Mass Spectrometry: Methods and Applications
Since the introduction of electrospray ionization (ESI) and matrix assisted laser desorption ionization (MALDI), there has been an unprecedented growth of biomolecule analysis using mass spectrometry (MS). One of the most popular applications for mass spectrometry is the field of proteomics, which …
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Laser ablation sample transfer for mass spectrometry
… to a solvent or surface. For off-line electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) analysis, the ablated material was captured in a static solvent droplet that was deposited on a MALDI target or flow-injected into a nanoelectrospray source. The …
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Molecular characterization of organically bound copper in the marine environment
… an inductively coupled plasma (ICP) MS and an electrospray ionization (ESI) MS. By using data supplied by both techniques, the molecular charateristics of CuLs were determined laboratory cultures of the marine diatom Phaeodactylum tricornutum and the cyanobacterium Synechococcus, as well as …
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Charge and momentum transfer processes for gas-phase nanoparticles.
… used in aerosol physics) and chemical ionization, both of which are collision based reactions. In diffusion charging theory, the occurrence of a back charging reaction is neglected, i.e. once an ion collides with a particle, charge is transferred to the particle, and the charged …
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Molecular Characterization of Organically Bound Copper in the Marine Environment
… an inductively coupled plasma (ICP) MS and an electrospray ionization (ESI) MS. By using data supplied by both techniques, the molecular characteristics of CuLs were determined laboratory cultures of the marine diatom Phaeodactylum tricornutum and the cyanobacterium Synechococcus, as well as …
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Method development for mass spectrometric characterization of ultra-small nanomolecules and mass spectrometry imaging of selected biomolecules
… (MSI). Chapter I includes introduction to electrospray ionization (ESI) and matrix assisted laser desorption ionization (MALDI) MS used in my PhD research. Chapter II explains how high resolution ESI-MS methods were developed to analyze the polar water-soluble NMs. These new methods express …
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A Deuterium Labeling Method for the Characterization of (Chromophoric) Dissolved Organic Matter Using Ultrahigh Resolution Electrospray Ionization Mass Spectrometry
… (NaBD4) and is analyzed via ultrahigh resolution electrospray ionization (ESI) mass spectrometry. Ketone/aldehyde-containing species (at mass m) in the untreated sample are identified by searching the mass spectrum of the reduced sample for peaks corresponding to deuterated derivatives (at mass …
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Measuring steroids from dried blood spots using tandem mass spectrometry to diagnose congenital adrenal hyperplasia
… that occur due to defects in the steroidogenesis pathway within the adrenal glands. CAH is characterized by numerous clinical manifestations resulting from dysregulation of various enzymes in the steroidogenesis pathway. Approximately 90% of CAH cases can be diagnosed by the measurement of …
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Enhanced Electrospray Ionization for Mass Spectrometry and Ion Mobility Spectrometry
Electrospray ionization (ESI) has become one of the most commonly used ionization techniques for mass spectrometry (MS) and ion mobility spectrometry (IMS), and efforts continue to improve its performance. ESI-MS is most recognized for its wide application to biomacromolecules where high …
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Mass spectrometry-based characterization of cell-to-cell signaling molecules in the nervous system
… four different MS platforms which cover both electrospray ionization (ESI) and matrix assisted laser desorption/ionization (MALDI) were used to characterize cell-to-cell signaling molecules secreted by or contained in animal models of rotifers, mice and rats in both a targeted and untargeted …
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Identification of Phenolic Compounds from Peanut Skin using HPLC-MSn
… liquid chromatography (HPLC) coupled with electrospray ionization (ESI) ion trap mass spectrometry (MSn). Prior to this study, approximately 20 compounds have been identified in peanut skins. The combination of Toyopearl SEC with ESI-HPLC-MSn allowed for the identification of 314 …
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