Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"electron transport chain (ETC)"”.
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Metabolic Reprogramming in Response to Mitochondrial Electron Transport Chain Dysfunction
Mitochondrial electron transport chain (ETC) diseases are genetic disorders of energy production with an occurrence rate of approximately 1:4300 and no effective treatment options. Here we show in vitro models of mitochondrial ETC dysfunction display shunting of major carbon sources (glucose and …
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AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
… molecule contains the information to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated protein kinase (AMPK) is a kinase that can initiate mitochondrial biogenesis and mitophagy. We hypothesized that treating cells …
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Investigations of the mechanism of mitochondrial complex I by electron cryomicroscopy
… of metabolism and relaying the liberated electrons through a series of membrane-embedded oxidoreductase proteins known as the electron transport chain (ETC). The first enzyme in the ETC is complex I (NADH:ubiquinone oxidoreductase). Complex I oxidises NADH in the matrix, reduces ubiquinone …
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Mitochondrial Contributions to Schizophrenia Symptom Severity: A GWAS Approach in a South African Population
… was nominally associated with variants in electron transport chain (ETC) and mitoribosomal genes, alongside epistatic interactions involving the SLC25A solute carrier family. These findings support a pathogenic model wherein substrate starvation and respiratory chain collapse drive the …
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Integrity of the Barrier Epithelium in Drosophila Gut is Mediated by Factors That Regulate Intestinal Stem Cell Activity
… A phenotypic correlation between autonomous electron transport chain (ETC) dysfunction was observed in the visceral muscle and the systemic UPRmt response of ISCs in the posterior midgut. Exploratively, two genome-wide association studies (GWAS) using the Drosophila genetic reference panel …
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AQP1—A REGULATORY FACTOR ASSOCIATED WITH BROWN ADIPOSE TISSUE SILENCING TO COMBAT OBESITY AND METABOLIC DISEASE
… had upregulated gene expression related to the electron transport chain (ETC) and mitochondrial translation. Thus, I demonstrate that ablation of AQP1 in BAT protects mice against DIO by increasing whole body energy expenditure through upregulation of the core ETC and mitochondrial translation …
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Exploring Protoheme IX Farnesyltransferase as an Antimalarial Drug Target
… cofactor of cytochromes within the mitochondrial electron transport chain (ETC), we infer that function of PfCOX10 is related to ETC-dependent essential processes such as pyrimidine biosynthesis. In this work, we take advantage of modern techniques to explore PfCOX10 as a potential new target of …
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Evaluating Determinants of Mitochondrial Mutagenesis and their Intersections with Cell Fate
… own DNA (mtDNA) which encodes elements of the electron transport chain (ETC). Aberrations in the mitochondrial genome are associated with neurodegenerative diseases, metabolic syndromes, cancer, and pathologies of aging; although establishing direct links between cause and consequence of mtDNA …
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The effects of hyperglycaemia on neuronal mitochondria
… functions. Through the processes of the electron transport chain (ETC) and oxidative phosphorylation, mitochondria convert pyruvate into adenosine triphosphate(ATP), a primary energy carrier. Mitochondria play an essential role in providing cellular energy by manufacturing ATP, buffering …
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Protein Factors Regulating Mitochondrial Respiratory Supercomplexes
… ATP production is achieved using the electron transport chain (ETC), whereby the controlled oxidation of biomolecules is coupled to the activity of ATP synthase. ETC complexes organize into supramolecular structures called supercomplexes (ETC SCs). Protein factors regulating ETC SCs …
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The Role of Mitochondrial Alternative Oxidase in Plant-pathogen Interactions
… conserving branch of the mitochondrial electron transport chain (ETC) which has been hypothesized to modulate the level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in plant mitochondria. The aim of the research presented herein is to provide direct evidence in …
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Identifying Metabolic Liabilities in Hürthle Cell Thyroid Carcinoma
… that are predicted to impair complex I of the electron transport chain (ETC). Consistent with these mutations, our work shows that HTC models harboring mitochondrial DNA-encoded defects in complex I of the mitochondrial electron transport chain exhibit impaired respiration and alterations in …
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Distribution of S-(2-Succinyl)Cysteine In the Tissues of Animal Models of Diabetes and Obesity
… increased nutrients cause a back up of the electron transport chain (ETC) and a buildup of Krebs cycle intermediates, including fumarate. Previously, we have seen increased succination in adipose tissue of the db/db type 2 diabetic mouse model. Consequently, this study focuses on the …
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Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… deprivation, hypoxia and treatment with an electron transport chain (ETC) uncoupler caused neuron loss and axonal damage in in vitro co-cultures of myenteric neurons, intestinal smooth muscle cells and glia. Furthermore, we investigated the potential impact of subsequent reperfusion on …
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Non-canonical roles for STAT1 and STAT2 in mitochondrial biogenesis and fasting homeostasis.
… levels of nuclear encoded components of the electron transport chain (ETC). Treatment of wild-type mice with IFNβ inhibits both mitochondrial and nuclear transcription of the ETC components. The inhibition of mitochondrial encoded transcription by IFNβ is both STAT1 independent and dependent …
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Ankyrin Dependent Mitochondrial Function and Bioenergetics In The Heart
… increased oxygen consumption through the electron transport chain (ETC), overproduction of reactive oxygen species (ROS), decreased mitochondrial membrane potential (MMP), and inefficient oxidative phosphorylation (OXPHOS)/ATP production. Altogether, these results further elucidate the …
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Hypoglycemia In Mitochondrial Disorders
<p><strong>INTRODUCTION</strong>: The electron transport chain (ETC) in mitochondria functions to produce energy in the form of adenosine triphosphate (ATP). Defects in the mitochondrial or nuclear DNA that codes for components of the ETC lead to mitochondrial disorders (MTDs). MTDs are …
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Mitochondrial genetic variation in the evolution of humans and metabolism of cancer
… nonsynonymous and located in coding regions for electron transport chain (ETC) subunits or important control regions, in addition to another 18 mutations in nuclear genes predicted to have important mitochondrial or metabolic function. Additionally, significant variation was observed in metabolic …
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Investigation of the proteomic interaction profile of uncoupling protein 3 and its effect on epigenetics
… electrochemical proton gradient formed by the electron transport chain (ETC) from ATP production. Though the prototypical uncoupling protein 1 (UCP1) is known to mediate the cold-induced thermogenesis in rodents and human neonates, the physiological and biochemical functions of the homologs …
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Manipulating Guard Cell Anatomy and Physiology Using Biotechnological Approaches to Understanding Impact on Crop Performance
… involve GC chloroplasts, during photosynthetic electron transport chain (ETC) and Calvin cycle activities. Ferredoxin (Fd) protein plays an important role in regulating the production of ATP and photosynthetic reductants as well as activation of the Calvin cycle enzymes. Anatomical features such …
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