Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 137 for “"electron transport chain"”.
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Metabolic Reprogramming in Response to Mitochondrial Electron Transport Chain Dysfunction
Mitochondrial electron transport chain (ETC) diseases are genetic disorders of energy production with an occurrence rate of approximately 1:4300 and no effective treatment options. Here we show in vitro models of mitochondrial ETC dysfunction display shunting of major carbon sources (glucose and …
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Qo site of the bc1 complex; unlocking the gate of the electron transport chain
The bc1 complex of the electron transport chain is critical to production of ATP through the proton gradient driven by quinone oxidation; a ubiquitous mechanism for energy conversion throughout the biosphere. In addition to being a central source of energy transduction, its bypass reactions can …
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Disassembly of electron transport chain complexes drives macrophage TLR responses by reprogramming metabolism and translation
… (TLR) disrupts the assembly of mitochondrial electron transfer chain (ETC) complexes I-V, leading to the metabolic switch by inhibiting OxPhos and activating HIF-1[alpha]-dependent glycolysis. Disassembly of ETC complexes influences the global metabolic status of macrophages not only by …
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Age-Related Deficits in Electron Transport Chain Complexes in Rat Neurons and 3xTg-AD Mouse Neurons
… finding key differences in CCO, we examined the electron transport chain more closely and found age-related deficits in quantity or function for each individual complex. Our experiments support a lack of endogenous substrates or a failure of upstream complexes to transport electrons to complex IV …
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The Contextual Roles of Isocitrate Dehydrogenase-1 and Isocitrate Dehydrogenase-2 in Electron Transport Chain Complex III Deficiency
… II (UQCRC2), a nuclear-encoded subunit of electron transport chain complex III (ETCIII). Only a handful of UQCRC2-deficient patients have been described worldwide, and none have been subjected to a detailed metabolic analysis to understand the impact of defects in this protein. We used …
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Intracellular Dynamics of Hydrogen Peroxide in Escherichia Coli
… H2O2 does not appear to be a result of the electron transport chain. However, these results did confirm that specific flavoenzymes, shown in vitro to make H 2O2, can autoxidize and adventitiously contribute to cytosolic H2O2 formation in vivo. However, the most substantial H2O2 generator …
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Electron Transport in Methanosarcina: Pathway Heterogeneity Within the Genus
Electron transport during methanogenesis in the freshwater methanogen Methanosarcina barkeri is known to utilize hydrogenases to transfer electrons from ferredoxin to methanophenazine. This thesis characterizes electron transport in the marine methanogen Methanosarcina acetivorans. Genomic …
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Characterization of the Electronic and Molecular Structures of Transition Metal Semiquinone and Catecholate Complexes
… with transition metal ions in biological electron transfer processes such as photosynthesis and the respiratory electron transport chain. Two types of quinones exist, paraquinones and orthoquinones, however, only transition metal-orthoquinone complexes were studied. Orthoquinones are only …
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Identifying Metabolic Liabilities in Hürthle Cell Thyroid Carcinoma
… that are predicted to impair complex I of the electron transport chain (ETC). Consistent with these mutations, our work shows that HTC models harboring mitochondrial DNA-encoded defects in complex I of the mitochondrial electron transport chain exhibit impaired respiration and alterations in …
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ISOLATION OF ELECTRON TRANSPORT COMPONENTS FROM MICROCYSTIS AERUGINOSA AND OSCILLATORIA SP
… the study of the cyanobacterial photosynthetic electron transport chain provides a useful model for higher plant systems. In this project, cytochrome c 553, plastocyanin and ferredoxin, all water-soluble components of the cyanobacterial electron transport chain, were isolated and purified from …
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Increased Oxidative Phosphorylation In An Ipsc- Derived Model of Rothmund-Thomson Syndrome Associated Osteosarcomagenesis
… of genes which encode complex I of the electron transport chain, were upregulated. We next demonstrated that the observed transcriptional changes led to phenotypic changes in enzyme activity. We then explored the nature of oxidative phosphorylation and glycolysis in RTS osteoblasts and …
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Mitochondrial genetic variation in the evolution of humans and metabolism of cancer
… nonsynonymous and located in coding regions for electron transport chain (ETC) subunits or important control regions, in addition to another 18 mutations in nuclear genes predicted to have important mitochondrial or metabolic function. Additionally, significant variation was observed in metabolic …
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Molecular analysis of the role of mitochondria in aging and lengevity
… diseases and sarcopenia. Mitochondrial electron transport chain (ETC) complexes I and III are the principle sites of ROS production, and oxidative modifications to their complex subunits inhibit their in vitro activity. Therefore, we hypothesize that mitochondrial complex subunits are …
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Structural and biochemical studies on enzymes involved in natural product biosynthesis and cellular respiration
… with this process, especially that of the electron transport chain. B. subtilis is also one of the most heavily studied and utilized organisms, with its genome completely sequenced and easily found in soil, gastrointestinal tracts of humans, and other readily accessible sources. However …
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AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
… molecule contains the information to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated protein kinase (AMPK) is a kinase that can initiate mitochondrial biogenesis and mitophagy. We hypothesized that treating cells …
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Investigating the Role of Complex I Loss in Thyroid Tumorigenesis
… demonstrate widespread loss of Complex I of the electron transport chain. TCV-PTC is a clinically aggressive form of papillary thyroid cancer, driven universally by the BRAF V600E activating mutation. I have developed a murine model of Braf-driven thyroid cancer to investigate the role of Complex …
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Isolation of a Siderophore Produced by Methicillin-Resistant <em>Staphylococcus aureus</em> Strain H372.
… for many cellular processes such as the electron transport chain and gene regulation. However, most iron on earth is found in insoluble iron-hydroxide complexes. In addition, iron is tightly sequestered in the human body by proteins such as transferrin, making it unavailable for …
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THE PROSURVIVAL ACTIVITIES OF APOPTOSIS-INDUCING FACTOR CONVERGE UPON THE REGULATION OF MITOCHONDRIAL METABOLISM, A NOVEL CELL DEATH PATHWAY, AND THE PROGRESSION OF PROSTATE CANCER
… and decreases to the protein complement of the electron transport chain resulting in diminished oxidative phosphorylation. Along with the ability to promote healthy mitochondrial function, AIF has demonstrated a supportive role in cancer cell growth which may be connected to its ability to …
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Role and regulation of mitochondrial permeability transition in cell death
… phenomenon. Lastly, the MPT was regulated by the electron transport chain since THG-induced cell death was inhibited in cells lacking mtDNA.
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Investigations of the mechanism of mitochondrial complex I by electron cryomicroscopy
… of metabolism and relaying the liberated electrons through a series of membrane-embedded oxidoreductase proteins known as the electron transport chain (ETC). The first enzyme in the ETC is complex I (NADH:ubiquinone oxidoreductase). Complex I oxidises NADH in the matrix, reduces ubiquinone …
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