Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"electron transfer dissociation"”.
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Development Of Matrix Assisted Ionization Methods For Characterization Of Soluble And Insoluble Proteins From Native Environments By Mass Spectrometry
… mass resolution and mass accuracy, and electron transfer dissociation. The surface method approach enables the detection, characterization, and identification of compounds directly from native environments such as tissue. The use of gas phase ion mobility separation reduces spectral …
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Top-Down Interrogation And Characterization Of Biological Macromolecules
… of ion/ion reaction and gas-phase unimolecular dissociation. The first part of the thesis deals with gas phase fragmentation behavior of chemically modified oligonucleotides. Factors, such as the observation time-scale, the ion type and the energy deposition method, are explored using a …
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Sampling, Detection, and Characterization of Endogenous Peptides
… techniques such as collisionally induced dissociation (CID) and electron transfer dissociation (ETD). The Sweedler group has used multiple MS techniques to help unravel the complex mechanisms involved in neuronal function. The primary goal of my dissertation research is to use MS coupled …
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Mass Spectrometric Analysis of Thiol Proteins/Peptides Following Selenamide Derivatization And Electrolytic Reduction of Disulfide Bonds
… coverage can be significantly improved for electron-capture dissociation (ECD) and collision-induced dissociation (CID) analysis. Furthermore, the online coupling of LC with liquid sample DESI-MS was established, which allows a wide range of elution flow rates, online derivatization …
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Mass spectrometry studies of immunoglobulins
… tandem MS techniques including collision-induced dissociation (CID), higher-energy collisional dissociation (HCD) and electron transfer dissociation (ECD). PTMs observed include truncations, mono-/di-chlorination of the tyrosine residues and a nitrile group formed from the primary amine on lysine …
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Multidimensional liquid chromatographic separations for proteomics
… an HCT ion trap (Bruker Daltonics) equipped with electron transfer dissociation has allowed in-depth analysis of intact proteins. Sample types investigated to establish the utility of the methodology include bacterial lysates (Bordetella parapertusis, and Escherichia coli), a eukaryotic parasite …
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Computational methods and machine learning for crosslinking mass spectrometry data analysis
… peptides in a crosslink under collision-induced dissociation conditions. The subsequent coverage gap between the two peptides in a crosslink may lead to misidentifications. This thesis presents computational approaches and machine learning methods to improve the identification of crosslinked …