Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"electron paramagnetic resonance (EPR) spectroscopy"”.
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Spin Chemistry of Guest@Host Systems: H₂@C₆₀ and Nitroxide@Octa Acid
This thesis describes the nuclear and electronic spin chemistry of incarcerated guest molecules to form a guest@host complex in conjunction with the utility of nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopy. The first chapter describes the background and …
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Picosecond studies of free radical reactions in solution
The 2,7-dihalofluorenylidenes were examined. Electron paramagnetic resonance (EPR) spectroscopy shows that these carbenes are ground-state triplets. These carbenes react with methanol to form 9-methoxy ethers. The absence of a heavy atom effect in this reaction suggests that intersystem crossing is …
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Investigating Ligand Induced Conformational Changes in the Estrogen Receptor
… site-directed spin labeling (SDSL), along with electron paramagnetic resonance (EPR) spectroscopy. In this work, B and C parameter calculations from EPR line-shape theory express receptor differences quantitatively as a spectrum of conformational change. Relative squared difference (RSD) …
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Towards low dose retrospective dosimetry on shelled species
… species for retrospective dosimetry using electron paramagnetic resonance (EPR) spectroscopy. To determine applicable samples for low dose studies, shells of crustacean and mollusc species were irradiated to 10 Gy using a 137Cs source. Reference dosimetry was performed with alanine powder …
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Conformational changes in actinin-type actin binding domains: probing actin-induced structural dynamics in dystrophin and utrophin using EPR spectroscopy.
… poorly understood: x-ray crystallography and electron microscopy have produced conflicting models. Electron paramagnetic resonance (EPR) spectroscopy, especially double electron-electron resonance (DEER), can be used to distinguish between these models or to build new models. In this thesis, I …
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Dynamics characterization for designing functional soft materials
… and characterization of samples spin-labeled for electron paramagnetic resonance (EPR) spectroscopy. By this approach, I developed insight into several soft-materials systems, including abiotic peptide tags, combinatorially selected for bioconjugation; fibronectin mimetic peptides, designed for …
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A novel wideband 140 GHz gyrotron amplifier
… cylindrical confocal waveguide using a gyrating electron beam. The electromagnetic theory, interaction theory, design processes and experimental procedures have been described in detail. The experiment has produced over 820 W peak power, 34 dB linear gain, and a -3 dB bandwidth of over 1.5 GHz …
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A study of SecA : the motor of the bacterial secretion system by site-directed spin labeling and EPR
… structure. We investigated these issues using electron paramagnetic resonance (EPR) spectroscopy and site-directed spin labels at a multitude of sites on the surface of the 102 kDa SecA protein. EPR spectroscopy is sensitive to changes in the local environment of the spin label, and thus our …
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Biospeciation, Interaction with Biomolecules and Mechanism of Action of Potential Cu and V Drugs
… ionization mass spectrometry (ESI-MS), electron paramagnetic resonance (EPR) spectroscopy, quantum-mechanical (QM) calculations, and molecular docking. These studies identified specific binding sites, competition between ancillary ligands and protein residues, and stabilization of …
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High-frequency time domain electron paramagnetic resonance : methods and applications
… advantages to high frequency (high field) electron paramagnetic resonance (EPR) spectroscopy. Two of the most important are improved sensitivity and the improved resolution of field dependent interactions. In addition, there are many attractive features to time domain spectroscopy. Pulsed …
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Nitroxides in Mechanistic Studies: Ageing of Gold Nanoparticles and Nitroxide Transformation in Acids
… reactions of AuNPs were studied by Electron Paramagnetic Resonance (EPR) Spectroscopy and a nitroxide spin label was introduced onto the gold surface in the process. Ageing of thiolate protected AuNPs results in reduced reactivity in the disulfide exchange. By studying the ligand and …
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Structure and Function of a Cytochrome P450 From Synechocystis Sp. PCC 6803
… produced oxygen in the primitive atmosphere, representing an interesting, evolutionarily ""old"" bacterial group. Over 60 cytochrome P450 or cytochrome P450-like genes have been identified in 22 cyanobacterial genomes. The universal distribution of P450s in cyanobacteria suggests that these …
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Structural Biology in Cellular Environments Using Sensitivity Enhanced NMR
… proteins. A brief primer of NMR, DNP and EPR is also provided in this chapter. Chapter 2 describes the development of methodology to maintain biological integrity of mammalian cells during DNP NMR. Description of a novel method to insert samples into a spectrometer is added as a …
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Small molecule motion within and through organic nanomaterials: an anthology
… chemical domains of an AA nanoribbon through Electron Paramagnetic Resonance (EPR) spectroscopy. These experiments were enabled by co-assembly of AAs with stable nitroxide radical spin labels into the nanoribbon ensemble. Distinct conformational behavior is resolved between domains, and …
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Lipid-Protein Interactions by Advanced EPR Methods
… important. In this work we have utilized Electron Paramagnetic Resonance (EPR) spectroscopy to investigate the chemistry of the phospholipid biding protein Sec14p, and the insertion profiles of synthetic peptides corresponding to the E2 transmembrane domain of selected mutants of the …
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Mechanisms and Implementation of Thermo-Optical Annealing in Silica Fiber Sensors for Radiation-Induced Attenuation Mitigation
… We design a white light absorption spectroscopy setup with in-situ irradiation and optical annealing, working at liquid nitrogen temperature and different post-irradiation warm-up rates. For the pure silica core and F-doped cladding fibers studied, the RIA spectrum obtained is …
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Insights into the radiation Chemistry of FLASH Radiation Therapy
… adducts (•DMPO-OH, •DMPO-H) were quantified via electron paramagnetic resonance (EPR) spectroscopy 120 s post-irradiation. Analytical correction for decay kinetics was applied to estimate initial •OH and •H yields.</p> <p><strong>Results:</strong> The BC showed excellent linearity and stable …
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Dynamics of lattice vibrations, molecular rotations and spins studied by terahertz spectroscopy
… using organic nonlinear optical crystals and spectroscopy experiments utilizing THz pulses to study the linear and nonlinear responses of molecular dipole, spin, and lattice degrees of freedom in molecular and condensed-matter systems. We have developed several THz spectroscopy methods …
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Exploration of Alkyne-bridged Multi[(Porphinato)metal] Oligomers for Charge Transport Applications and Spin-Spin Exchange Coupling Properties Using Synthetic, Spectroscopic, Potentiometric, and Magnetic Resonance Methods
<p>As silicon-based microelectronics approaches its fundamental physical limit, molecular electronics is emerging as a promising candidate for future ultra-dense electronic devices with individual molecules as active device components. The emerging of molecular spintronics, which exploits the …
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Spectroscopic characterization of iron-oxygen intermediates in human aromatase (CYP19A1)
… cancer prognosis. CYP19A1 is a membrane-bound hemeprotein with a rich spectroscopic landscape thus affording an opportunity to apply a repertoire of biophysical approaches to help piece together a reaction mechanism. I used the Nanodisc technology to stabilize CYP19A1 in its native membrane-like …
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