Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"electron capture dissociation"”.
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Improved Dynamic Range, Quantitation, and Characterization of Histone H4 Post-Translational Modifications: A Top Down Mass Spectrometric Approach
… (Q-FTMS) with Top Down fragmentation using Electron Capture Dissociation (ECD). We extend the use of Top Down MS to assess how the abundance of each modified histone H4 form changes in synchronized cells progressing through the cell cycle in order to identify PTMs and combinations of PTMs …
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Investigations of biological interactions by hydrogen deuterium exchange Fourier transform ion cyclotron mass spectrometry: novel methods, automated analysis and data reduction
… by Horn (THRASH) algorithm for the analysis of electron capture dissociation (ECD) spectra. Speed improvements in THRASH arise from optimized libraries and use of modern processors. The nonergodic nature of ECD alleviates deuterium scrambling and affords improved localization of exchange data. …
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Mass Spectrometric Analysis of Thiol Proteins/Peptides Following Selenamide Derivatization And Electrolytic Reduction of Disulfide Bonds
… coverage can be significantly improved for electron-capture dissociation (ECD) and collision-induced dissociation (CID) analysis. Furthermore, the online coupling of LC with liquid sample DESI-MS was established, which allows a wide range of elution flow rates, online derivatization …
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Hydrogen-deuterium exchange studies by mass spectrometry: A method for obtaining conformational structures of proteins in solution
… phase fragmentation of the deuterated peptide by electron capture dissociation (ECD). The results show that this top-down approach is feasible for HDX MS method. The ECD fragmentation of the doubly charged ion of deuterium labeled substance P after chromatographic separation method that eliminated …
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Structural Comparison of Denatured and Supercharged Proteins in Gas and Solution Phases
Mass spectrometry has become a popular tool for studying large biomolecules due to its high sensitivity. Mass spectrometry techniques like ion mobility separation and fragmentation methods allow for top-down analysis to determine protein structures. As a gas phase technique, it is crucial to …