Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"electrical excitability"”.
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Ion channels and electrical excitability in native murine anterior pituitary corticotrophs
… pituitary corticotrophs as both endocrine and electrically excitable cells with a number of ion channels and signaling pathways implicated in the control of their electrical properties and ACTH secretion. However, the mechanisms involved in native corticotrophs are poorly understood partly due …
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Devices for Extracellular Detection of Astrocytic Infraslow Electrophysiological Biomarkers
… capable of detecting low-amplitude infraslow electrical signals. Conventional electrodes are invaluable tools for neural electrophysiology, however, their application in astrocytes is hampered by the lower electrical excitability of these cells compared to neurons. In this thesis, organic …
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The Role of Time Variant Resistance and Electromotive Force in Ionic Systems Related to Cell Membranes: The Excitability Properties of Frog Skin and Toad Bladder
<p>Central to the modern theory of the electrical properties of cells is the permeability of the plasma membrane to the ions passing across this structure; it has been our purpose to explore, both theoretically and experimentally, the physical implications of this point-of-view. The cornerstone of …
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Functional Importance of Oxidative Post-Translational Modifications of Ryanodine Receptor in Cardiac Sarcoplasmic Reticulum Ca2+ Handling During Oxidative Stress
… is compromised, both the contractility and electrical excitability of the heart can be altered. As a consequence, heart function may not be able to maintain the necessary cardiac output to meet the metabolic demand of the body.</p><p>Increased oxidation of RyR2 has been implicated in …
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The neurotoxicity of acrylamide
… biochemically or histologically. The electrical excitability of the nerve terminal region of phrenic motor nerves was reduced following acrylamide although a possible compromise of antidromic action potential conduction could not be confirmed. There was no histopathological evidence of …
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Luminescence Resonance Energy Transfer Studies of the Shaker Potassium Voltage-Gated Ion Channel
… channels are the molecular components underlying electrical excitability in nerves and muscle. Voltage-gated channels allow the selective flow of ions across the hydrophobic lipid bilayer of a cell, opening and closing in response to changes in the voltage across the membrane. The Shaker K+ …
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Angiotensin II signalling in sensory neurons
… by Ang II, as evidenced by an increase in electrical excitability of IB4-binding neurons following overnight Ang II incubation. In summary, experiments detailed in this Thesis have revealed that Ang II stimulated nociceptive sensory neurons in vitro. Ang II-evoked Ca2+ signals were mediated …
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Regulation of glucagon secretion from pancreatic alpha cells
… β-cells, which produce insulin, α-cells are electrically excitable and equipped with different ion channels. But unlike β-cells, α-cells electrical activity is only possible within a narrow window of low K(ATP) channel activity. At low glucose, the K(ATP) channels are almost fully – but not …
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Identification, Characterization and Function of Voltage-Gated and Two-Pore-Domain Potassium Channels in the Mouse Myometrium.
I am interested in the contractility and electrical excitability in the uterus at the level of individual uterine myocytes throughout gestation. 1 believe by determining potential targets for functional changes in uterine excitability I may be able to uncover the key player(s) in the regulation of …
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Mechanical Control of Sensory Hair-Bundle Function
… a hair bundle exhibits mechanical excitability analogous to the electrical excitability of neurons. This behavior implies for the first time a direct relationship between the mechanical behaviors of sensory organelles and the electrical behaviors of afferent neurons. Man-made …