Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"electrical coupling"”.
-
Brain Stimulation Reward is Integrated by A Network of Electrically-Coupled GABA Neurons
… connexin-36 (Cx36) gap junctions and couple electrically with dopamine application or by stimulation of the internal capsule (IC), which also supports self-stimulation. The threshold for responding for self-stimulation of the IC is the threshold for coupling between these GABA neurons, the …
-
Neuronal and Molecular Adaptations of GABA Neurons in the Ventral Tegmental Area to Chronic Alcohol
… and suppression of gap-junction (GJ) mediated coupling between these neurons by acute ethanol (Stobbs, Ohran et al. 2004), we wanted to further characterize the effects of chronic ethanol on VTA GABA neuron excitability, electrical coupling and molecular adaptation. In particular, we analyzed …
-
Mutations in Connexin43 and Connexin40 Associated with Human Atrial Fibrillation; Physiology and Mechanism
… arrhythmia, is a disease that affects the electrical conductance in the atria. Gap junction channels, composed of connexin (Cx) proteins, allow the electrical signal to propagate between cardiac myocytes. Mutations in two highly expressed cardiac connexin genes, GJA1 (Cx43) and GJA5 (Cx40), …
-
Gatekeeper Connexin43 Phosphorylation Events Regulate Cardiac Gap Junction Coupling During Stress
… effecting not only direct intercellular electrical coupling, but the localization of other junctional structures and ion channels. Alterations in Cx43 expression occur in essentially all forms of heart disease and is therefore a topic of intense study. Posttranslational modification of …
-
Network activity arising from optimal diameters of neuronal processes
Electrical coupling provides an important pathway for signal transmission between neurons. In several regions of the mammalian brain electrical synapses have been detected, and their role in the synchronization of neural networks and the generation of oscillations has been studied theoretically. …
-
Motion Processing in Direction Selective Retinal Ganglion Cells through Dynamic Environments
… type-dependent adaptation: connexin36-mediated electrical coupling and differences in effective GABAergic inhibition. In Chapter 6, I show with a simulation of DSGC activity based on data that this adaptation strategy is beneficial for balancing motion detection and direction estimation at the …
-
Nonlinear Dynamics, Synchronisation and Chaos in Coupled FHN Cardiac and Neural Cells
… communication between cells be it through electrical coupling or synaptic like coupling, can lead to the emergence of chaotic behaviour. I also show that in the presence of emergent chaos one �nds great variability in intervals of activity between the constituent cells. This implies that …
-
Flexible Strain Detection Using Surface Acoustic Waves: Fabrication and Tests
… micro and nanofillers’ structural, thermal and electrical properties are investigated. Piezoelectric property measurements are carried out for different filler combinations to optimize the suitable materials, examining flexibility and favorable characteristics. Electromechanical properties are …
-
Functional nanoelectronic devices: single-electron transport, memristivity, and thermoelectricity in nanoscale flms using self-assembly and graphene
… tunnelling with a high yield. The electrical properties of the junctions are studied individually and collectively using statistical tools to extract correlations between device geometries and electrical data. The dissertation includes discussion of the theory of relevant electronic …
-
Auditory Processing Deficits in MSH2-KO mice are linked to Aberrant Inhibitory Neuron Function in the Thalamic Reticular Nucleus
… protein connexin-36 (Cx36). Cx36 is required for electrical coupling between TRN neurons, regulating the degree of synchrony in firing patterns. This indicates that Cx36- expressing PV<sup>+</sup> cells in the TRN undergo increased gap junction coupling, thus leading to dysfunction in the …
-
Investigating the coordination of cardiac conduction and repolarization in ventricular myocardium
… either ephaptic (EpC) or gap junctional (GJ) coupling between cardiomyocytes can modulate cardiac conduction, repolarization, or the relationship between these two phenomena. Our lab has previously demonstrated that EpC can be modified in the ventricular epicardium using ionic and osmotic …
-
Signaling Mechanisms That Control Gap Junctional Coupling Between Retinal Neurons
… neurons form the structural substrate for electrical synapses. Connexin 36 (Cx36, and its non-mammalian ortholog connexin 35) is the major neuronal gap junction protein in the central nervous system (CNS), and contributes to several important neuronal functions including neuronal …
-
Mathematical modelling and brain dynamical networks
… measure and their dependence on the values of electrical and chemical couplings. We analyse the dynamics of neurons in various regions of parameter space plots for two elementary examples of 3 neurons with two different types of electrical and chemical couplings. We plot the upper bound Ic and …
-
Interplay between Ephaptic and Gap Junctional Coupling in Cardiac Conduction
… like cellular excitability, tissue structure and electrical coupling by gap junctions (GJ), have been extensively studied. However, there are several discrepancies in cardiac electrophysiology research that have extended over decades, suggesting elements that are still not completely understood …
-
Ink jet printing of PZT thin films for MEMS
… titanate (PZT) has the strongest mechanical to electrical coupling. PZT based devices have the potential to have the highest performance. Due to the strong piezoelectric response and low operating voltage, many groups have worked to integrate thin film PZT into a wide range of …
-
Coupled phenomena in arrays of microplasma devices and microchannel plasma devices as antennas
… The microplasmas were optically and electrically probed in this work. The investigation showed that each plasma is physically separated and yet, under the proper conditions, is optically and/or electrically coupled to its neighbors. In arrays as large as 10 parallel microchannel …
-
Basal and agonist activated calcium sensitization pathways in murine gastrointestinal smooth muscles
… directly stimulate SMC but stimulate ICC to set electrical coupling with SMC. This study opens a door for taking similar approach to address ICC role in other types of neurotransmission in the GI tract. In summary, gastric antrum, gastric fundus and proximal colon smooth muscles have different …