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Biomechanical and Molecular Approaches to Aortic Valve Disease in a Mouse Model

Krishnamurthy, Varun K.University of Cincinnati2012

… (ECM) remodeling are hallmark features of AVD. Elastin is one of the primary ECM proteins in the aortic valve and is responsible for valve extension and recoil. Mutations or deletions in the elastin gene cause elastin haploinsufficiency, a clinical condition associated with valve abnormalities …

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