Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"elastin"”.
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Bioorthogonal Functionalization of Elastin-like Polypeptides
… platforms comprised of a unique biopolymer, elastin-like polypeptide (ELP). This thermally responsive biopolymer is easily recombinantly synthesized, though more biochemically complex ELPs require successful bioorthogonal modification. We designed the unnatural amino acid-containing ELPs …
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Leukocyte Response to Elastin-Like Polypeptide Coatings
… thrombosis. The extracellular matrix protein elastin has been found to be one of the least thrombogenic components of blood vessels, and its purified and recombinant forms have shown reduced thrombogenicity in both in vitro and in vivo models. Biomaterial coatings of elastin-like polypeptides …
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Elastin-Like Peptide Dendrimers: Design, Synthesis, and Applications
Elastin like peptides (ELPs)—derived from the protein elastin—are widely used as thermoresponsive components in biomaterials due to their LCST (lower critical solution temperature) behavior at a characteristic transition temperature (Tt). While linear ELPs have been well investigated, few reports …
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Programmable Assembly of Elastin-like Polypeptides Within Droplet Microenvironments
… and consists of programming the assembly of elastin-like polypeptides, an archetypal class of disordered proteins, into model organelles within droplet microenvironments. We synthesized a library of recombinant elastin-like polypeptides, and studied their phase separation and assembly into …
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Understanding Elastin-Like Polypeptide Block Copolymer Self-assembly Behavior
<p>Elastin-like polypeptides (ELPs) are thermally responsive polymers composed of the pentapeptide repeat Valine-Proline-Glycine-X-Glycine where X is any amino acid except proline. ELP diblocks have been engineered by creating two ELP blocks with hydrophilic and hydrophobic guest residues. The …
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Expression, Purification, And Characterization Of Elastin-Like Polypeptides Containing Chondroitin Sulphate Binding Domains
… a small-diameter blood vessel. Using recombinant elastin-like polypeptides (ELPs) developed by the Woodhouse laboratory, as well as chondroitin sulphate-specific binding sequences (CSBD1 and CSBD2) determined by the Panitch laboratory, a new elastin-like polypeptide-chondroitin sulphate binding …
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Mechanics and Modeling of Postnatal Arterial Development in Mouse Models of Varying Elastin
… output. This unique ability is made possible by elastin in the ECM that imparts elastic behavior to the artery. Genetic mutations that affect the amount and organization of elastin result in congenital cardiovascular defects that lead to lifelong cardiovascular complications. In order to devise …
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Pregnancy Induced Alterations of Reproductive Tract Collagen and Elastin in a Murine Model
… dynamical modifications of reproductive tract elastin and collagen as a function of parity. Pelvic floor dysfunction, including pelvic organ prolapse (POP) is a major concern affecting female health worldwide, leading to surgeries costing billions of dollars annually. Collagen, elastic fibers, …
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Molecular structure, hierarchical assembly and stimuli-responsive mechanics of tropoelastin and elastin biomaterials
The elastin polymer, assembled from its molecular precursor tropoelastin, is the dominant component of elastic fibers, which confer elasticity and structural integrity to skin, lung, connective and vascular tissue. Historically, elastin's dynamic nature has precluded traditional approaches such as …
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Elastin-like polypeptide (ELP) tags for self-assembly and high-throughput processing of functional protein materials
… bioconjugate materials with a genetically fused elastin-like polypeptide (ELP) tag. The first part of this thesis explores the effects of ELP charge and hydrophobicity on the self-assembly of ELP-mCherry fusion proteins in concentrated solution.
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The Effect of Fascicular Elastin on the Mechanical and Functional Properties of Healthy, Damaged, and Healing Tendon
… subunit of tendon, the fascicle, the role of the elastin protein remains understudied despite impressive extensibility and fatigue resistance of its resulting elastic fibers. While previous work catalogued contributions of fascicular elastin across tendon type and species, the anticipated effects …
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Defining the Role of Elastic Fibers in Tendon Mechanics
… organization. Other structural proteins, such as elastin, are in comparison understudied and not well understood in relation to tendon function. Elastin, the main component of elastic fibers, has unique mechanical properties including high extensibility, fatigue resistance, and elasticity; these …
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Osteoblast-like cell response to titanium coated with co-immobilized Elastin-like polymers containing integrin-binding and Statherin-derived biomimetic peptides
… two biomimetic peptides via a covalently bound elastin-like biopolymer (p-). The co-immobilized titanium surfaces had either a 1:1 molar ratio of biomimetic peptides on separate biopolymers (pRGD and pSNa15) or a coating containing both peptides on a single biopolymer (pRGD-SNa15). Cellular …
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Aging Effects on Arterial Mechanics and Matrix Remodeling
… of extracellular matrix proteins, in particular elastin and collagen. Elastin provides reversible elasticity to the large elastic arteries during cyclic loading and dampens the pulsatile flow from the left ventricle, reducing the workload on the heart and protecting the end organs. …
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Characterization and Modulation of the Emergent Material Properties of Biomolecular Condensates
… we next examined a model system based on tropoelastin, an extracellular protein relevant in connective tissue assemblies like lungs, arteries, and cartilage. The coacervation and cross-linking process of tropoelastin culminates in the formation of elastin fibers, a resilient biomaterial capable …
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Biomechanical and Molecular Approaches to Aortic Valve Disease in a Mouse Model
… (ECM) remodeling are hallmark features of AVD. Elastin is one of the primary ECM proteins in the aortic valve and is responsible for valve extension and recoil. Mutations or deletions in the elastin gene cause elastin haploinsufficiency, a clinical condition associated with valve abnormalities …
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