Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"elafin"”.
-
Imbalance Between Neutrophil Elastase and Elafin Promotes Breast Cancer Growth and Progression
<p>Elafin, an endogenous serine protease inhibitor, is a critical component of the epithelial barrier against neutrophil elastase (NE) activity. The central hypothesis examined in this dissertation was that elafin has tumor suppressive properties in breast cancer. In support of this hypothesis, …
-
Modulation of dendritic cells by human neutrophil elastase and its inhibitors in pulmonary inflammation
… Over-expression of an NE specific inhibitor (elafin) in the lungs of mice (using either replication-deficient adenovirus [Ad] or elafin transgenic [eTg] mice) increased the number (immunofluorescence) and activation status (flow cytometric measurement) of CD11c+/MHCII+ lung DCs in in vivo …
-
The impact of HIV exposure status and maternal feeding practice on the concentration of SLPI and E/tr-2 protein in infant saliva and maternal breast milk
… leukocyte protease inhibitors (SLPI) and Elafin/trappin-2 (E/tr-2). At physiological concentrations SLPI and E/tr-2 have been shown to inhibit in vitro HIV replication in human monocytes and epithelial cells, respectively. Study Aims 1) To determine the impact of HIV infection/ exposure on …