Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"eicosanoid"”.
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Involvement of eicosanoid signalling in epithelial cell migration
… and the machinery producing them such as the eicosanoids. Changes in the expression of extracellular matrix proteins and their related integrin receptors have also been shown to be important in the advancement IBD and CC. In light of this, we have investigated the role of eicosanoids in cell …
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The Group IVA Cytosolic Phospholipase A2/C1P Interaction and Its Role in Eicosanoid Synthesis and Inflammation
… is crucial for production of eicosanoid synthesis in inflammation. Inflammation is a critical component of many disease states including anaphylaxis, cancer, cardiovascular disease, rheumatoid arthritis, diabetes and asthma. Eicosanoids are well established mediators of …
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The influence of the hormonal milieu on eicosanoid and cytokine production in tissues from the female reproductive tract.
In the human uterus prostaglandins (PG) PGE2, PGD2, PGI2, PGF2¿ and Thromboxane A2 (TXA2), also termed prostanoids, are synthesised and deactivated to 15-keto PGE2, J2 metabolites, 6-keto-PGF1¿, 15-keto PGF2¿ and TXB2 respectively. However, not all metabolites have been analysed simultaneously …
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Nanotoxicity of oxide-derived engineered nanomaterials: impact on cell viability and function, with conventional assays and evaluation of novel eicosanoid profiling
… method for nanotoxicological screening. Eicosanoid profiling was used to assess both toxicity and inflammatory markers associated with a panel of ENMs, this technique is novel for the use in testing of ENM and the results show it has potential to be introduced/applied as an effective tool …
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A Combined Computational Strategy of Sequence and Structural Analysis Predicts the Existence of a Functional Eicosanoid Pathway in <i>Drosophila melanogaster</i>
… roles in signal transduction and metabolism, eicosanoids have emerged as important players in human health and disease. Mammalian prostanoids and related lipid mediators perform varied functions in different tissues and organs. Synthesized through the oxygenation of C20 polyunsaturated fatty …
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Immune Mediators of Murine Lyme Arthritis
… fish oil substitution leads to a global shift in eicosanoid production (from AA/LA-derived eicosanoids to EPA/DHA-derived eicosanoids) and promotes antiinflammatory prostaglandin production, disease severity is not altered. (4) We found that eicosanoid production throughout the course of …
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
… regulation of both eosinophilic inflammatory and eicosanoid pathways. We first show that nasal polyposis/aspirin intolerance was associated with increased concentrations of eosinophil-related mediators, as well as of IgE antibodies to S. aureus enterotoxins. Furthermore, eicosanoid release …
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The role of eicosanoids in the human skin's response to ultraviolet radiation.
… by immunohistochemistry for leukocyte subtypes, eicosanoid producing enzymes and NO synthases under basal and UVR-stimulated conditions. In addition primary cultures of epidermal melanocytes (EM) were established from 16 individuals (8 SPT-1 & 8 SPT-4) and assessed for the presence of …
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THE ROLE OF BOTANICAL OILS ENRICHED IN FADS2-DERIVED N-3 VS. N-6 POLYUNSATURATED FATTY ACIDS IN PREVENTION OF ATHEROSCLEROSIS
… for pro-inflammatory and anti-inflammatory eicosanoid production, which affect atherosclerosis progression and inflammation. We previously showed that an atherogenic diet containing echium oil (EO), which is relatively enriched in stearidonic acid (18:4 n-3), the immediate product of …
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Immunomodulatory Effect Of Host And Fungal Eicosanoids During Host-Pathogen Interactions With Candida Albicans
… that cross-react functionally with host eicosanoids, which are considered to play important role in regulating innate and adaptive immune responses. Our objective was to characterize the role of prostaglandins produced by the host and this fungus during host pathogen interactions, both in …
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Feeding Female Growing Rats Different Sources of Omega-3 Polyunsaturated Fatty Acids Affects Lung Fatty Acid Composition and Gene Expression
… the expression of various genes involved in eicosanoid production and oxidative stability.;Objective: to determine whether providing different sources of n-3 PUFAs will affect the fatty acid composition, inflammation and oxidation in the lungs of growing rats.;Methods: Growing (age 28 d) …
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The Signaling Pathway of Oxysterol-Induced Apoptosis in Macrophages.
… (MPMs). Pharmacological inhibition of eicosanoid synthesis or genetic knockout of important eicosanoid biosynthetic genes had no significant effect on the induction of apoptosis by oxysterols in macrophages. The induction of apoptosis in macrophage cell lines and MPMs by oxysterols and …
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Dietary Omega-3 Fatty Acids, Cell-Mediated Cytotoxicity and Anti-Tumorigenic Activity in Balb/c Mice
… alter CMC and tumor growth is through changes in eicosanoid production. One study demonstrated that feeding a diet containing 10% by weight linseed oil (LO), which contains over 50% 18:3n-3, significantly reduced prostaglandin (PG) and leukotriene production by immune cells. That natural and CMC …
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The role of seminal plasma in the regulation of inflammation and inflammatory pathways in the cervix: potential for cervical cancer progression and HIV transmission in South African women
… revealed that SP regulates the activation of eicosanoid, toll-like receptor-NFκB, kallikrien-bradykininbradykinin receptor, cytokine, and chemokine signaling pathways to mediate the expression of inflammatory mediators in cervical cancer cells. These data highlight the potential of SP to …
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Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis
… Since AA release is the rate limiting step in eicosanoid production, it is possible that cPLA2α might play a central role in the development of Ang II-induced hypertension. To test this hypothesis, we investigated the effect of Ang II infusion for 13 days by micro-osmotic pumps (700 ng/kg/min), …
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Effect of Fatty Acid Modification on Prostacyclin Production in Cultured Human Endothelial Cells (Arachidonate, Elcosapentaenoate)
… 6-keto-PGF(,1(alpha)). Radiolabelled fatty acid eicosanoid products were separated by reverse phase HPLC. Unconverted fatty acid was the major product released upon thrombin stimulation in both cases. ('3)H-AA supplemented cells also released PGI(,2) and HETE in lesser amounts while ('14)C-EPA …
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Signal transduction in macrophages. Intracellular pathways activated by microbial constituents
… mediators. Such mediators are TNF? and eicosanoids. Many microbial agents elicit arachidonate release in macrophages that lead to the formation of eicosanoids. This thesis is based on studies performed with the use of microbial constituents which induce arachidonate release or/and TNF? …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… PCs was concomitant with increases in bioactive eicosanoid secretion, which was shown to be important in the control of ER stress, inflammatory signalling and macrophage activation. This provides a novel link between palmitate and the control of ER stress and inflammation in metabolic disease. …
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Mouse modifiers of intestinal tumorigenesis
… production of arachidonic acid for downstream eicosanoid synthesis.
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Neuroglial Mechanisms Involved In The Anti-Inflammatory Effect Of Acetate Supplementation
… (MAPK), nuclear factor-kappa B (NF-κB), and eicosanoid signaling. A single oral dose of acetate treatment (6 g/kg) in normal animals induced a time- and site-specific pattern of histone hyperacetylation, associated with reduction of histone deacetylase (HDAC) activity and expression. …
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