Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"egr-1"”.
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IL-1β Amplification of Nitric Oxide Production and Its Inhibitory Effects on Glucose Induced Early Growth Response-1 Expression in INS-1 Cells
… fully understood. Early growth response gene-1 (Egr-1) expression is specifically and transiently up regulated in pancreatic beta cells in response to glucose. We hypothesized that interleukin-1 beta (IL-1▀) induction of nitric oxide alters glucose induced Egr-1 transcription levels. Egr-1 levels …
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Complexity of transcription factor target search: effect of DNA natural decoys and DNA methylation through interplay with methyl-CpG-binding proteins on transcription factor DNA association
… kinetics of the inducible transcription factor Egr-1 using stopped flow assays on a fluorescence spectrometer. We show that the impact of quasi-specific sites depends strongly on their affinity to Egr-1 and on their concentration, and that the presence of these sites are highly probable within …
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Transcriptional regulation of the Human Zfm1/Sf1 Gene
… (dODN) gegen die Transkriptionsfaktoren EGR-1 und SP-1 zeigten, dass beide Proteine be ider Expression von Zfm1 eine Rolle spielen; während SP-1 eine hohe basale Expression vermittelt, spielt EGR-1 eine ungewöhnliche Rolle. Im Falle des Zfm1-Gens führt Bindung der Faktors an den Promoter …
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Charakterisierung des Chemokinrezeptors CXCR3 in humanen proximalen Tubuluszellen der Niere
… der Expression des Early Growth Response Gene-1 (EGR-1) kommt, wurden weitere Experimente mit EGR-1 überexpremierenden IHKE-1-Zellen gemacht. Es konnte gezeigt werden, dass es bei EGR-1 überexpremierenden IHKE 1 Zellen zu einer Herabregulation der Kupfer Zink Superoxiddismutase (Cu/ZnSOD) und der …
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Ontogeny of contextual fear conditioning: behavioral, neuropharmacological and molecular mechanisms
… factor early growth response-1 gene (Egr-1) vary based on training phase and brain sub-region in adult and adolescent rats (Asok, Schreiber, Jablonski, Rosen, & Stanton, 2013; Chakraborty, Asok, Stanton, & Rosen, 2016; Schreiber, Asok, Jablonski, Rosen, & Stanton, 2014). Importantly, …
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Towards understanding molecular, sub-molecular and atomic mechanisms of facilitated target search on DNA
… scanning by the inducible transcription factor Egr-1, we sought answers to the following fundamental questions: What dictates the efficiency in DNA scanning? Can we modulate it? What are the atomic determinants of target DNA search? This work has provided quantitative insights into the …
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A plazma XIII-as faktor hatása a vaszkuláris simaizomsejtek funkcióira
… monocita és fibroblaszt sejtek felszínén lévő integrin fehérjék keresztkötésével olyan jelátviteli útvonalat indukál, melynek hatására a sejtek proliferálnak és/vagy migrálnak. A folyamat során egyes angiogén fehérjék (Egr-1, c-Jun) expressziója fokozódik, az anti-angiogén fehérjéké, mint a …
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Hormonal mechanisms for variation in female mate choice
… early gene (IEG) induction, specifically egr-1, was used to mark neuron activity. Females were treated with either HCG or saline and exposed to either mate choruses or silence. Egr-1 expression was quantified in an auditory midbrain nucleus, the torus semicircularis (TS). The region within …
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NMR Studies on Protein Dynamics and Its Relevance to Functional Kinetics.
… kinetics of human transcription factor Egr-1. Nature has designed Egr-1 in such a way, at the same time with strong DNA binding affinity for high target specificity, that it is rapid enough in translocation on the human genome to satisfy requirements of its biological functions. Our data …
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Estrogen action in the myocardium
… target gene, the early growth response gene-1 (Egr-1) and 3) to initiate the search for novel estrogen target genes in the myocardium. 1) The effects of estrogen on the expression of one of the major myocardial specific contractile proteins, the alpha-myosin heavy chain (alpha-MHC) have been …
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A cell-based sensor of fluid shear stress for microfluidics
… using qRT-PCR, which resulted in the choice of EGR-1 upregulation as the node for FSS detection. A reporter plasmid with a minimal EGR-1 promoter driving the expression of Turbo-RFP fluorescence was chosen and the cell sensor was created by stable transfection and clonal selection. Inducing the …
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Expression and regulation of N-Myc Downstream- Regulated gene 1 in squamous cell carcinoma of the oesphagus
… (ChIP) assays, we showed that both EGR-1 and cJun/AP-1 are capable of driving transcription of NDRG1 in response to 12-o-tetradecanoylphorbol- 13-acetate (TPA) through activation of PKC/MEK/ERK1/2 and JNK MAPK pathways. Taken together, we describe the regulation of NDRG1 expression …
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Transcriptional response to spatial learning and foraging in honey bees: molecular bases for adult neuroplasticity
… of the insect brain involved in sensory integration, learning and memory. Honey bees (Apis mellifera) learn to navigate in the environment surrounding the hive by performing orientation flights for several days before they begin to forage; both orientation flights and foraging are …
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The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
… entry and dissemination, epithelial barrier integrity, and the resolution of inflammatory responses. Syndecan-1 (SDC1), a major heparan sulfate chain-bearing proteoglycan, traditionally characterized as a primary attachment receptor that facilitates HSV-1 binding and entry through its heparan …
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Exploring the fathering brain: insights from neural activation
Organisms require a great deal of behavioral plasticity to accomplish the tasks associated with reproduction. In addition to day-to-day activities, breeding animals must establish a territory, find a mate, find a place to raise offspring, mate and rear offspring. While organisms are breeding, they …
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Efectos antineoplásticos y antiinflalmatorios de agonistas del receptor vitamina D en el sarcoma de Kaposi
… independientemente de la disminución de HIF-1α y EGR-1, posiblemente por regulación directa del promotor de VEGF por parte del VDR. A su vez, la expresión del mensajero del factor anti-oncogénico JunB aumentó, mientras que el mensajero del factor pro-oncogénico c-Fos sólo disminuyó durante cortos …
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Chemical genetic manipulation of interferon regulatory factor 1 (IRF-1) using synthetic biology
… genes such as, early growth response-1 (EGR-1) and prostate transmembrane protein, androgen induced-1 (PMEPA1) confirming the role of IRF-1 as a tumour suppressor. However, we also reported the up-regulation of secreted phosphoprotein-1 (SPP1) and SH3 and PX domains-2A (SH3PXD2A) which …