Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"efflux pump inhibitors"”.
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Assay Setup for High Throughput Screening to Identify Novel Efflux Pump Inhibitors against Escherichia coli
… kuten E. colille, on ominaista efluksipumput, joiden yli-ilmentäminen soluseinärakenteessa on seuraus efluksipumppujen pumppauskapasiteetin ylittymisestä esimerkiksi bakteereiden altistuessa pitkäjatkoisesti matalille, bakteerikasvua estämättömille antibioottipitoisuuksille. Tutkituin …
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Design, synthesis and biological evaluation of verapamil analogues, reversed isoniazids and hybrid efflux pump inhibitors against Mycobacterium tuberculosis
… drug degradation, target modification and drug efflux. Drug efflux by efflux pumps (EPs) is one of the major mechanisms responsible for the development of drug tolerance leading to the emergence of drug resistance. These efflux pumps are regulated by the house keeping proteins present in the …
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SCREENING FOR POTENTIAL ANTIBACTERIAL AGENTS AND THE APPLICATION OF ISOTOPIC LABELS FOR THE CHARACTERIZATION OF THEIR EFFECTS ON THE DYNAMICS OF THE BACTERIAL 16S RIBOSOMAL RNA
… growth. We also observed that the use of efflux pump inhibitors in combination with the fragments enhanced their antibacterial properties and may help combat multidrug resistance. In addition, using a chemoenzymatic isotopic labeling strategy, we observed by NMR a slight modification of …
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Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria
… residence through the induction of distinct efflux pumps that are also required for intracellular growth. My findings provide a mechanistic explanation for the clinical tuberculosis treatment data gathered over the last 50 years where the length of treatment required for cure correlates with …
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The Chemical Analysis and Biological Activities of the Secondary Metabolites from Dalea mollis and Dalea albiflora
… not limited to, the production of biofilms and efflux pumps. Efflux pumps prevent antimicrobial drugs from reaching their biological target, so the coordinated use of efflux pump inhibitors and antimicrobial drugs has been identified as a potential treatment for multidrug-resistant …
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Studies on the mechanism of zinc pyrithione resistance in Pseudomonas aeruginosa PAO1
… resistance, multiple antibiotic resistance, efflux systems and stress response.<br/><br/>Results indicate that the ZnPT-resistant phenotype exhibited an increase in cell surface hydrophobicity and LPS changes. When outer membrane protein profiles of ZnPT-resistant cells and ZnPT-sensitive …
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Elucidation of mechanisms of antibiotic subversion in mycobacteria
… drug inactivating systems, and the activity of efflux pumps. This study aimed to investigate the role of various components of the "intrinsic resistome" that limit the efficacy of antitubercular agents. The DNA damage response: the SOS response was hypothesized to play a role in antibiotic- …
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Understanding Bacterial Resistance and Dissemination: The Impact of Biocide Priming
… tolerance and cross resistance to antibiotics. Efflux pump inhibitors (thioridazine and chlorpromazine) were used to investigate efflux as a mechanism. Known antibiotic resistance genes were sequenced to look for any mutations and Quantitative Realtime PCR was used to compare their regulation …
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Anti-asthmatic and anti-cough activities of the essential oil Of Eucalyptus Grandis W. Hill Ex Maiden
… essential oil. Cytosolic LDH was released and efflux pump inhibition activity was monitored to determine the apparent bactericidal mechanism of the essential oils. Antioxidant activity (free radical scavenging of nitric oxide, hydroxyl radical, superoxide anion, and also the sulfhydryl, NADH as …