Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 475 for “"efflux"”.
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Structural mechanism for multidrug efflux systems
… heavy metal ions, is the expression of membrane efflux transporters that recognize and actively export these toxic compounds out of bacterial cells, thereby allowing them to survive in extremely toxic conditions. Many of these transporters are multiple drug binding proteins which extrude …
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Efflux-Mediated Multidrug Tolerance in Replicating Mycobacteria
… residence through the induction of distinct efflux pumps that are also required for intracellular growth. My findings provide a mechanistic explanation for the clinical tuberculosis treatment data gathered over the last 50 years where the length of treatment required for cure correlates with …
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On the Structure and Function of Multidrug Efflux Pumps
… export drugs through the intrinsic activity of efflux pumps. In this work, a summary is provided of our current understanding of the structures and molecular mechanisms of multidrug efflux pumps in bacteria (Chapter 1). The emerging picture of the structure, function and regulation of efflux …
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Analysis of resistance nodulation division efflux pumps in Acinetobacter baumannii
… expressed resistance nodulation division (RND) efflux pump was adeFGH. A collection of A. baumannii isolates from the environment showed decreased susceptibility to at least three antibiotics and expression of three RND efflux pumps (adeFGH, adeABC, adeIJK). From the clinical collection two …
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Exosomes act as molecular vehicles contributing to cellular cholesterol efflux
Exosomen sind Vesikel mit einer Größe von 50-100 nm, welche den intraluminalen Vesikeln der multivesikulären Endosomen (MVE) entsprechen und bei der Fusion von MVE mit der Plasmamembran in die extrazelluläre Umgebung sekretiert werden. Die Sekretion von Exosomen konnte für eine Reihe von …
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Cloning and characterization of AdeMNO RND efflux pump of Acinetobacter baumannii
… of Resistance-Nodulation-cell Division (RND) efflux pumps in the antibiotic resistance mechanism of A. baumannii. Expression of six different RND pumps was analyzed in clinical isolates of A. baumannii. A novel RND family pump, AdeMNO, was found to be present in a majority of isolates. The …
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EVASION OF EFFLUX AND ENHANCING BIOAVAILABILITY OF AMPRENAVIR BY PRODRUG DERIVATIZATION
… (CNS) permeation of PIs is the presence of efflux proteins on brain capillary endothelial cells. There are several reports demonstrating that PIs are substrates of efflux proteins which limit their oral bioavailability and brain permeation. Various approaches have been employed to evade the …
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Purification and characterisation of the Escherichia coli multidrug efflux protein MdtM
… cause of MDR has been identified as the efflux of antimicrobials from the cell by proteins which are integral membrane transporters. Escherichia coli MDR transporter, MdtM, is a previously uncharacterised, 410 amino acid residues protein from the ubiquitous major facilitator superfamily …
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Expression of the multi-drug efflux genes acrAB of Escherichia coli
The action of AcrAB-ToIC, a multidrug efflux system of Escherichia co/i, is largely responsible for the increased intrinsic resistance of this organism to many antimicrobial agents. The level of mRNA specific to the acrAB efflux genes is elevated by six-fold during exponential phase of growth in LB …
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Combating HIV-1 by Targeting Drug Efflux Transporters on the Macrophage Reservoir
… In the previous research, we found that drug efflux transporters expressed differently between macrophage phenotypes. In this dissertation, we examined the effects of CSC, ethanol exposure, and AZM on the expression and function of clinically relevant drug efflux transporters, viral …
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Mechanistic studies of a multidrug efflux protein from <i>Escherichia coli</i>
… the mechanisms behind the MDR, including the efflux pumps which reduce cytoplasmic concentrations of antimicrobials to levels no longer toxic to the cell. One such membrane protein from Escherichia coli is MdtM, a 12 TM antiporter of the Major Facilitator Superfamily (MFS). MdtM, like other …
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Structural and Mechanistic Studies of Multidrug Resistance Efflux Pumps in Multiple Families
… is through the activities of multidrug efflux pumps. These pumps remove a variety of potentially noxious compounds from inside the cells of bacteria and other infectious organisms. In this study, I have looked at multiple families of efflux pumps in an effort to answer the most pressing …
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Investigating The Functional Relationships Of RND Efflux Pumps In Methicillin Resistant Staphylococcus Aureus
The RND superfamily of efflux pumps plays vital roles in the intrinsic defence mechanisms of bacterial pathogens. The staphylococci have two genes encoding RND transporters; farE, which promotes efflux of antimicrobial fatty acids, and an uncharacterized gene we have named femT. Although RND pumps …
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Structure and Dynamics of AcrA, a Periplasmic Component of a Multidrug Efflux Pump
AcrA is the periplasmic component of an efflux system AcrA-AcrB-TolC, which can expel different classes of antibiotics. AcrB is the inner membrane (IM) pump that utilizes proton-motive force for the active transport, TolC is the outer membrane (OM) channel, and AcrA coordinates the actions of AcrB …
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Effects of Fire on Soil CO₂ Efflux in a Mature Longleaf Pine Forest
… Lamar County, MS. Measurements of soil CO₂ efflux (i.e., soil respiration or SR) rates (µmol m<sup>-2 </sup>sec<sup>-1</sup>) were taken across 8 field plots (4 burned, 4 unburned) before and after a prescribed fire on that occurred in May, 2012. These measurements were taken over diurnal …
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Deciphering Multidrug Efflux: Substrate Interactions and Transport Mechanisms in PatAB and NorM-VC
Multidrug efflux transporters are ubiquitously expressed in all kingdoms of life. In bacteria, they participate in several innate physiological functions to aid survival and adaptation. Given their crucial roles in conferring antimicrobial resistance (AMR), the understanding of the structural and …
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Unbiased assessment of P-gp efflux towards designing blood—brain barrier penetrant compounds
The student, Aya Kelly, accepted the attached license on 2022-04-15 at 10:24.
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Influx and Efflux of Adenine Nucleotides From Erythrocytes Regulate Oxygen Transport and Systemic Metabolism
… pathway of adenine nucleotide influx and efflux that modulates erythrocyte’s oxygen binding ability and controls systemic metabolism. Our studies show that the loss of AMPD3 and CD73, two important enzymes in regulating AMP levels intra- and extra-cellularly, respectively, allows for an …
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The impact of hypoxia on nanomedicine uptake and efflux in human breast cancer cells
… cells had a significantly increased nanoparticle efflux (up to 9%, p<0.001) when compared tonormoxic cells (Chapter 3). Overall, this thesis has demonstrated thathypoxic preconditioning regulates both the endocytosis and exocytosis of nanomedicines in human breast cancer cells (Chapters 3 and 4).
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