Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 533 for “"effectors"”.
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Myogenic Effectors and Disease
Skeletal muscle is essential for life. Inside muscle fibers, filaments of actin and myosin slide on each other to generate the mechanical forces that drive muscle contraction, movement, and breathing. Mutations in muscle-related genes can cause severe diseases in humans. Here we characterize the …
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Pneumatic variable stiffness soft robot end effectors
Traditionally, robots have been formed from heavy rigid materials and have used stiff actuator technologies. This means they are not well suited to operation near humans due to the associated high risk of injury, should a collision occur. Additionally, rigid robots are not well suited to operation …
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Characterization of Mitochondrially Targeted T3SS2 Effectors in Vibrio parahaemolyticus
… enterotoxic effects. To date, only nine T3SS2 effectors have been identified within the T3SS2 pathogenicity island that contains 30-50 additional uncharacterized proteins. In the first part of this study, we performed a proteomics screen to identify T3SS2 effectors and found VPA1328, a novel …
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Identification and Characterization of Novel CRISPR-Cas Immune Effectors
… go on to activate additional accessory immune effectors encoded within type III CRISPR loci that provide immunity primarily through the activation of some toxic activity via their effector domains. The most common protein domain among these effectors is the CARF domain. This protein domain is …
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An expanded search for RNA-programmable genomic engineering effectors
… Interspaced Short Palindromic Repeat) single effectors, akin to the revolutionary genome-engineering tools Cas9 and Cpf1. Whereas previous search strategies relied on protein proximity to CRISPR-associated spacer acquisition proteins Cas1 and Cas2, this approach was seeded on CRISPR arrays …
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Investigation of Control Effectors for Ducted Fan VTOL UAVs
… of Re = 0.96 x 106 to 4.6 x 106. Various control effectors were mounted to the vehicle and tested for maximum control authority to reduce the nose-up pitch moment created during forward flight or with crosswinds present. Static and wind tunnel tests were conducted to measure each control …
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Functional Characterization of Four Xanthomonas euvesicatoria Type III Effectors
… functions of four Xe Type Three Secretion Effectors (T3Es): Xe-XopQ, Xe-XopX, Xe-XopN, and Xe-avrRxo1. Xe-XopQ is a Xe T3E that functions as a determinant of host specificity. Here, we further explored the virulent and avirulent functions of Xe-XopQ. We identified another T3E Xe-XopX that …
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Constrained control allocation for systems with redundant control effectors
Control allocation is examined for linear time-invariant problems that have more controls than degrees of freedom. The controls are part of a physical system and are subject to limits on their maximum positions. A control allocation scheme commands control deflections in response to some desired …
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Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
<p>About 8 and 10 percent of the human and mouse genomes, respectively, are comprised of sequences of retroviral origin. Occasional infection of germ line can lead to integrated retroviral genomes being vertically inherited as host alleles. During thousands to millions of years, some of these …
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Investigating Interferon-Inducible Antiviral Effectors Through a Virological and Evolutionary Lens
… field has focused on identifying antiviral ISG effectors and defining their mechanisms of action. However, fundamental gaps in knowledge about the interferon response remain. For example, it is unknown how many ISGs are required to restrict a particular virus, though it is theorized that …
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Identification of Receptor Transporting Proteins As Conserved Antiviral Effectors in Vertebrates
… conflicts are drawn. In mammals, many antiviral effectors -- proteins that directly inhibit viral infection -- show species- or lineage-specific properties which are believed to be the result of past or ongoing conflicts. Bats harbor a greater diversity of viruses than any other mammalian order, …
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… studies, I have characterized novel CARF effectors and also investigated the role of canonical CARF effector, Csm6, in mediating immunity against mutant targets. The first proteins I characterized are closely related homologs Chp1 and Chp2 (CRISPR-associated HAD phosphatase). These …
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STRUCTURE-FUNCTION STUDIES OF TRANSLOCATED EFFECTORS FROM THE LATE BLIGHT PATHOGEN
… of which translocate inside host cells. These effectors manipulate host processes for the pathogen’s benefit. However, in response to this manipulation, plants have evolved to monitor for effectors and trigger defence responses. Amongst plant pathogens, oomycetes of the genus Phytophthora have …
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The Role of Phytophthora Secreted Effectors in Determining Pathogen Host Range
… to be the major contribution to resistance as effectors are inappropriately attuned to perturb their orthologous plant targets. In contrast, effector triggered immunity (ETI) could be the major contributor to resistance in nonhost plants that are more closely related to the host plants. P. …
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Antimicrobial Effectors Act Cooperatively to Stress Salmonella in the Macrophage Phagosome
Salmonella Typhimurium survives and replicates in host macrophages. The bacterium produces two Cu-Zn periplasmic superoxide dismutases, SodCI and SodCII. Although both enzymes are expressed during infection, only SodCI contributes to virulence in the mouse by combating phagocytic superoxide. We …
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A New Approach To Identifying Effectors and Regulators of Small GTPases
… putative interactomes, identifying both known effectors and regulators as well as putative novel interactors for most tested GTPases. Several potential novel interactions were validated through GST affinity chromatography and/or microscopy, namely with the Rab GTPases Rab2A (ARFGEF3/BIG3, …
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Exchangeable end effectors for the army Explosive Ordnance Disposal (EOD) robot
… device was proposed as well as numerous end effectors to make the robot more adaptable to any given situation. Control and feedback system issues was also investigated that allowed the telerobot to have autonomous control during the end effector interchange sequence.
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