Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1226 for “"effector"”.
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Effector Shape and Motion Optimization
… co-optimizing the shape and motion of robotic effectors for planar tasks. An effector is a device, typically at the end of a robotic arm, used to interact with the environment. While planning object and robot-object contact trajectories is extensively studied, designing an effector that can …
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Effector-Based Goal and Operator Construction: A Model for the Design of Effector Adaptive Planners
… about the actions a planner can take called Effector-Based Goal and Operator Construction (EBGOC). The salient feature of this model is that the representation is based on effectors, the objects that enable actions, rather than the actions those effectors can produce. An effector-based …
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Kinematic evaluation of end effector design
The complex, many degree-of-freedom end effectors at the leading edge of technology would be unusable in the sea bottom research environment. Simpler designs are required to provide adequate reliability for subsea use. This work examines selection of end effector designs to achieve optimum grasping …
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Characterization of the Antiviral Effector IFI6
The innate immune response is a critical line of host defense against invading pathogens. The production of interferon (IFN) and the subsequent expression of interferon stimulated genes (ISGs) are major contributors to the innate immune response, which establish an antiviral state in the cell. …
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Antibody-Effector Functions in Antiviral Response
… (Fc) domain with Fc receptors (FcR) on effector leukocytes is essential for proper immunological function and bridges the humoral with the cellular components of immunity. While the Fc domain of immunoglobulin G (IgG) has historically been considered to be relatively constant, recent …
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COMPLIANT END-EFFECTOR COUPLING FOR ROBOTIC ASSEMBLY
… and has led to the development of compliant end-effectors and/or wrists. This thesis presents a novel passively compliant coupling, the compliant end-effector coupling (CEEC), that aids automated assembly. It serves as a mechanical interface between the end of the robot arm and the end-effector. …
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HEDGEHOG SIGNAL TRANSDUCTION IN EFFECTOR IMMUNE CELLS
… also been shown to be critical for CD8+ and CD4+ effector functions, acting in a cell-autonomous manner and downstream of the T-cell receptor. Whether this pathway is also functionally relevant in NK cells, an innate lymphocyte, has not been fully established. Moreover, the unique adaptations in …
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Effector-driven actin reorganisation restricts Salmonella invasion.
… host cell. To achieve this, Salmonella inject effector proteins into the cytosol of the cell and manipulate the actin cytoskeleton, driving pathogen entry. Two of the delivered effectors, namely SopE and SopE2, activate host Rho GTPases and subsequently the Arp2/3 complex, which results in …
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Effector Cells and Mechanisms in Chronic Spontaneous Urticaria
Background: Chronic spontaneous urticaria (CSU) is characterised by weals, angioedema, or both, which occur for six weeks or more. Itchy, red and raised weals in CSU are thought to occur as a result of skin mast cell activation, local vasodilatation and increased vascular permeability which are the …
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Engineering aglycosylated antibody variants with immune effector functions
… the engagement and activation of immune effector cells - mediated by the interaction of the conserved Fc regions of the antibody with the Fc gamma receptors (Fc[gamma]Rs) on immune cells - is critical to the efficacy of several. This thesis describes the engineering of antibody Fc domain …
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Identification and characterization of phosphoinositide-binding Legionella effector proteins
… for translocating these proteins, known as effector proteins, from the bacterial milieu into the host cytosol (Berger & Isberg, 1993; Segal & Shuman, 1998; Vogel, Andrews, Wong, & Isberg, 1998). Effector proteins do not share extensive homology amongst each other and are often composed of …
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Cargo Specific Regulation Of Cytoplasmic Dynein By Effector Proteins
… Hook3. Together, my work suggests that dynein effectors like Hook proteins can differentially regulate dynein to allow for organelle-specific tuning of the motor for precise intracellular trafficking.
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EFFECTOR T CELL HOMING TO THE SMALL INTESTINAL MUCOSA
… lamina propria (LP), contains a large number of effector/memory T cells that are thought to play a central role in the generation and maintenance of mucosal immune responses and in maintaining mucosal integrity. The work in this thesis investigates the mechanisms regulating effector T cell …
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Effector CD4⁺ T lymphocytes in the prodrome of polyarthritis
… that progressive differentiation or selection of effector cells is required before disease can be expressed. This study has charted the emergence of activated and arthritogenic CD4⁺ T cells in the inguinal and popliteal lymph nodes draining the site of inoculation, in the TD lymph and in the …
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Helicobacter pylori VacA as a mitochondrial targeted pathogenic effector
Mitochondria play a central role in life and death. Although mitochondrial dysfunction is at the core of many diseases, the mechanisms and consequences of mitochondrial targeting and dysfunction induced by pathogenic microbes is poorly understood. The vacuolating cytotoxin (VacA) of the human …
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Exploring antiviral effector cells in vaccinia virus-infected tissues
Vaccinia virus (VACV) is a large, double-stranded DNA virus belonging to the Poxviridae family that was used as the live vaccine leading to the eradication of smallpox. Despite eradication through global vaccination, the precise immune mechanisms underlying recovery from infection are incompletely …
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Research and development of a rescue robot end-effector
… design, development and testing of an end-effector system for use on an Urban Search and Rescue (USAR) robot which is in development in the Robotics and Agents Research Laboratory (RARL) at the University of Cape Town (UCT). This is the 5th generation Mobile Robot Platform (MRP) that UCT …
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Cloning and characterization of RIP1, an effector of Ral
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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